Arenavirus Diversity and Evolution: Quasispecies In Vivo

  • N. Sevilla
  • J. C. de la Torre
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 299)


Arenaviruses exist as viral quasispecies due to the high mutation rates of the low-fidelity viral RNA-dependent RNA polymerase (RdRp). This genomic heterogeneity is advantageous to the population, allowing for adaptation to rapidly changing environments that present varying types and degrees of selective pressure. The significant variation in biological properties observed among lymphocytic choriomeningitis virus (LCMV) strains, the prototypic arenavirus, indicates to what extent a quasispecies dynamics may play a role in arenavirus adaptability and pathogenesis. Several aspects of arenavirus variability and its contribution to pathogenesis will be discussed.


Lymphocytic Choriomeningitis Virus Viral Quasispecies Induce Growth Hormone Lassa Fever Virus World Arenaviruses 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • N. Sevilla
    • 1
  • J. C. de la Torre
    • 2
  1. 1.Centro de Biología Molecular Severo OchoaUniversidad Autónoma de MadridMadridSpain
  2. 2.Department of NeuropharmacologyThe Scripps Research InstituteLa JollaUSA

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