Lung Cancer Sentinel Lymph Node Small Cell Lung Cancer Mediastinal Lymph Node Neural Cell Adhesion Molecule 


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  1. Andre F, Grunenwald D, Pignon JP, Dujon A, Pujol JL, Brichon PY, Brouchet L, Quoix E, Westell V, Le Chevalier T (2000) Survival of patients with resected N2 non small cell lung cancer: evidence for a subclassification and implications. J Clin Oncol 18:2981–2989PubMedGoogle Scholar
  2. Coleman RE (1999) PET in lung cancer. J Nucl Med 40:814–820PubMedGoogle Scholar
  3. De Leyn P, Vansteenkiste J, Cuypers P, Deneffe G, Van Raemdonck D, Coosemans W, Verschakelen J, Lerut T (1997) Role of cervical mediastinoscopy in staging of non-small cell lung cancer without enlarged mediastinal lymph-nodes on CT scan. Eur J Cardiothorac Surg 12(5):706–712CrossRefPubMedGoogle Scholar
  4. Drings P (1998) Expert round table, Berlin 1998. Initiated by Schering AG, Berlin (minutes held at Schering)Google Scholar
  5. Ebner H, Marra A, Butturini E, De Santis F (1999) Clinical value of cervical mediastinoscopy in the staging of bronchial carcinoma. Ann Ital Chir 70(6):873–879PubMedGoogle Scholar
  6. Erasmus JJ, McAdams HP, Patz EF, Goodman PC, Coleman RE (1998) Thoracic FDG PET: state of the art. Radiographics 18:5–20PubMedGoogle Scholar
  7. Farrell MA, McAdams HP, Herndon JE, Patz EF (2000) Non-small cell lung cancer: FDG PET for nodal staging in patients with stage I disease. Radiology 215:886–890PubMedGoogle Scholar
  8. Fukose T, Hirata T, Naiki H, Hitomi S, Wada H (2000) Prognostic significance of proliferative activity in pN2 non small cell lung carcinomas and their mediastinal lymph node metastases. Am Surg 232:118–128Google Scholar
  9. Gress FG, Savides TJ, Sandler A, Kesler K, Conces D, Cummings O, Mathur P, Ikenberry S, Bilderback S, Hawes R (1997) Endoscopic ultrasonography, fine needle aspiration biopsy guided by endoscopic ultrasonography and computed tomography in the preoperative staging of non small cell lung cancer: a comparison study. Ann Intern Med 127:604–612PubMedGoogle Scholar
  10. Gu CD, Osaki T, Oyama T, Inoue M, Kodate M, Dobashi K, Oka T, Yasumoto K (2002) Detection of micrometastatic tumor cells in pN0 lymph-nodes of patients with completely resected non small cell lung cancer: impact on recurrence and survival. Ann Surg 235:133–139CrossRefPubMedGoogle Scholar
  11. Gupta NC, Graeber GM, Bishop HA (2000) Comparative efficacy of positron emission tomography with fluorode-oxyglucose in evaluation of small (<1 cm), intermediate (1 to 3 cm), and large (>3 cm) lymph node lesions. Chest 117:773–778CrossRefPubMedGoogle Scholar
  12. Higashi K, Nishikawa T, Seki H, Oguchi M, Nambu Y, Ueda Y, Yuasak Tonami H, Okimura T, Yamamoto I (1998) Comparison of fluorine-18-FDG PET and thallium-201 SPECT in evaluation of lung cancer. J Nucl Med 39:9–15PubMedGoogle Scholar
  13. Kalff V, Hicks RJ, MacManus MP, Binns DS, McKenzie AF, Ware RE, Hogg A, Ball DL (2001) Clinical Impact of (18)F fluorodeoxyglucose positron emission tomography in patients with non-small-cell lung cancer: a prospective study. J Clin Oncol 19:111–118PubMedGoogle Scholar
  14. Kawashima O, Kakegawa S, Otani Y, Kamiyoshihara M, Sugano M, Morishitta Y (2002) Clinical study of synchronous multiple primary lung cancers; problems in diagnosis and treatment. Kyobu Geka 55(19):20–24PubMedGoogle Scholar
  15. Keller SM, Adak S, Wagner H, Johnson DH (2000) Mediastinal lymph node dissection improves survival in patients with stages II and IIIa non-small cell lung cancer. Eastern Cooperative Oncology Group. Ann Thorac Surg 70(2):358–365CrossRefPubMedGoogle Scholar
  16. Korst RJ, Ginsberg RJ (2001) Appropriate surgical treatment of resectable non small cell lung cancer. World J Surg 25:184–188CrossRefPubMedGoogle Scholar
  17. Li S, Juco J, Mann KP, Holden JT (2004) Flow cytometry in the differential diagnosis of lymphocyte rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. Am J Clin Pathol 121(2):268–274CrossRefPubMedGoogle Scholar
  18. Liptay MJ, Masters GA, Winchester DJ, Edelman BL, Garrido BJ, Hirschtritt TR, Perlman RM, Fry WA (2000) Intraoperative radioisotope sentinel lymph node mapping in non small cell lung cancer. Ann Thorac Surg 70:384–389CrossRefPubMedGoogle Scholar
  19. Little AG, Delloyos A, Kirgan DM, Arcomano TR, Murray KD (1999) Intraoperative lymphatic mapping for non-small cell lung cancer: the sentinel node technique. J Thorac Cardiovasc Surg 117(2):220–234PubMedGoogle Scholar
  20. Lloyd C, Silvestri GA (2001) Mediastinal staging of non-small-cell lung cancer. Cancer Control 8(4):311–317PubMedGoogle Scholar
  21. MacManus MP, Hicks RJ, Matthews JP, Hogg A, McKenzie AF, Wirth A, Ware RE, Ball DL (2001) High rate of detection of unsuspected distant metastases by PET in apparent stage III non-small-cell lung cancer: implications for radical radiation therapy. Int J Radiat Oncol Biol Phys 50(2):287–293CrossRefPubMedGoogle Scholar
  22. Marom EM, Erasmus JJ, Patz EF (2000) Lung cancer and positron emission tomography with fluorodeoxyglucose. Lung Cancer 28:187–202CrossRefPubMedGoogle Scholar
  23. Motta G, Carbone E, Spinelli E, Nahum MA, Testa T, Flocchini GP (1999) Considerations about tumor size as a factor of prognosis in NSCLC. Ann Ital Chir 70(6):893–897PubMedGoogle Scholar
  24. Murasugi M, Onuki T, Ikeda T, Kanzaki M, Nitta S (2001) The role of video-assisted thoracoscopic surgery in the diagnosis of the small peripheral pulmonary nodule. Surg Endosc 15(7):734–736CrossRefPubMedGoogle Scholar
  25. Naruke T, Tsuchiya R, Kondo H, Akayama H, Asamura H (1999) Lymph node sampling in lung cancer: how should it be done? Eur J Cardiothorac Surg 16[Suppl 1]:S17–S24CrossRefPubMedGoogle Scholar
  26. Oda M, Watanabe Y, Shimizu J, Murakami S, Ohta Y, Sekido N, Watanabe S, Ishikawa N, Nonomura A (1998) Extent of mediastinal node metastasis in clinical stage I non small cell lung cancer: the role of systematic nodal dissection. Lung Cancer 22:23–30CrossRefPubMedGoogle Scholar
  27. Oosterhuis JW, Theunissen PH, Bollen EC (2001) Improved pre-operative mediastinal staging in non-small-cell lung cancer by serial sectioning and immunohistochemical staining of lymph-node biopsies. Eur J Cardiothorac Surg 20(2):335–338CrossRefPubMedGoogle Scholar
  28. Ota S, Inaba H, Yoshida H (2001) Rational lymph node dissection for lung cancer according to the occurrence lobe and histological type. Kyobu Geka 54:1073–1078PubMedGoogle Scholar
  29. Pieterman RM, Putten JW van, Meuzelaar JJ, Mooyaart EL, Vaalburg W, Koeter GH, Fidler V, Pruim J, Groen HJ (2000) Preoperative staging of non-small-cell lung cancer with positron-emission tomography. N Engl J Med 343:254–261CrossRefPubMedGoogle Scholar
  30. Ramnath N, Hernandez FJ, Tan DF, Huberman JA, Natarajan N, Beck AF, Hyland A, Todorov IT, Brooks JS, Bepler G (2001) MCM2 is an independent predictor of survival in patients with non-small-cell lung cancer. J Clin Oncol 19(22):4259–4266PubMedGoogle Scholar
  31. Ryan A, Banks J, Roberts S (2001) Methods for lung cancer biopsy. Lancet 358(9296):1909–1910CrossRefGoogle Scholar
  32. Sawabata N, Maeda H, Ohta M, Hayakawa M (2001) Operable non-small cell lung cancer diagnosed by transpleural techniques: do they affect relapse and prognosis? Chest 120(5):1595–1598CrossRefPubMedGoogle Scholar
  33. Schinkel C, Müller C, Reinmiedl J, Hoffmann H, Zimmer S, Dienemann H, Fuerst H (1999) Mediastinal lymph node infiltration in non small cell lung cancer and its role in curative surgery. Scand Cardiovasc J 33:286–288CrossRefPubMedGoogle Scholar
  34. Serna DL, Aryan HE, Chang KJ, Brenner M, Tran LM, Chen JC (1998) An early comparison between endoscopic ultrasound guided fine needle aspiration and mediastinoscopy for diagnosis of mediastinal malignancy. Am Surg 64:1014–1018PubMedGoogle Scholar
  35. Shiau YC, Hsieh JF, Tsai SC, Ho YJ, Sun SS, Kao CH (2000) Technetium-99m methoxy-isobutyl-isonitrile chest single photon emission computed tomography to detect mediastinal lymph node metastasis in patients with non small cell lung cancer: comparison with computed tomography. Anticancer Res 20(5C):3751–3754PubMedGoogle Scholar
  36. Spiessl B, Beahrs OH, Hermanek P, Hütter RVP, Scheibe O, Sobin LH, Wagner G (1990/1993) TNM Classification. Springer, Berlin Heidelberg New YorkGoogle Scholar
  37. Tahara RW, Lackner RP, Graver LM (2000) Is there a role for routine mediastinoscopy in patients with peripheral T1 lung cancers? Am J Surg 180:488–491CrossRefPubMedGoogle Scholar
  38. Takamochi K, Nagai K, Yoshida J, Suzuki K, Ohde Y, Nishimura M, Sasaki S, Nishiwaki Y (2001) Pathologic N0 status in pulmonary adenocarcinoma is predictable by combining serum carcinoembryonic antigen level and computed tomographic findings. J Thorac Cardiovasc Surg 122(2):325–330CrossRefPubMedGoogle Scholar
  39. Tanaka F, Yanagihara K, Otake Y, Li M, Miyahara R, Wada H, Ito H (2000) Biological features and preoperative evaluation of mediastinal nodal status in non-small cell lung cancer. Ann Thorac Surg 70(6):1832–1838CrossRefPubMedGoogle Scholar
  40. Vansteenkiste JF, Stroobants SG, De Leyn PR, Dupont PJ, Bogaert J, Maes A, Deneffe GJ, Nackaerts KL, Verschakelen JA, Lerut TE, Mortelmans LA, Demedts MG (1998) Lymph node staging in non-small-cell lung cancer with FDG-PET scan: a prospective study on 690 lymph node stations from 68 patients. J Clin Oncol 16:2142–2149PubMedGoogle Scholar
  41. Watanabe Y, Murakami S, Oda M, Ohta Y, Watanabe S, Nozawa H, Kamesui T, Nozaki Y, Nonomura A, Minato H, Kitagawa M (1999) Tumor size and extension of lymph node metastases in N2 lung cancer. Ann Ital Chir 70:889–892PubMedGoogle Scholar
  42. Wu Y, Wang S, Huang Z (2001) Extent of lymphadenectomy in stage I-IIIA non-small cell lung cancer: a randomised clinical trial. Zhonghua Zhong Liu Za Zhi 23(19):43–45PubMedGoogle Scholar
  43. Yanagi S, Sugiura H, Morikawa T, Kaji M, Okushiba S, Kondo S, Katoh H (2000) Tumor size does not have prognostic significance in stage Ia NSCLC. Anticancer Res 20(2B):1155–1158PubMedGoogle Scholar
  44. Yang ST, Zhou YZ, Zeng J (1999) 99mTc-MIBI single-photon emission-computed tomography in diagnosis of lung cancer and mediastinal metastasis lymph-nodes. Zhongguo Yao Li Xue Bao 20(9):800–804PubMedGoogle Scholar

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