Blimp-1; Immunoglobulin Secretion and the Switch to Plasma Cells

  • R. Sciammas
  • M. M. Davis
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 290)


The transcription factor Blimp-1 governs the generation of plasma cells and immunoglobulin secretion. Recent microarray experiments indicate that Blimp-1 regulates a large set of genes that constitute a significant part of the plasma cell expression signature. The variety of differentially expressed genes indicates that Blimp-1 affects numerous aspects of plasma cell maturation, ranging from migration, adhesion, and homeostasis, to antibody secretion. In addition, Blimp-1 regulates immunoglobulin secretion by affecting the nuclear processing of the mRNA transcript and by affecting protein trafficking by regulating genes that impact on the activity of the endoplasmic reticulum. Interestingly, the differentiation events that Blimp-1 regulates appear to be modulated depending on the activation state of the B cell. This modulation may be due at least in part to distinct regions of Blimp-1 that regulate unique sets of genes independently of each other. These data hint at the complexity of Blimp-1 and the genetic program that it initiates to produce a pool of plasma cells necessary for specific immunity.


Plasma Cell Unfold Protein Response Immunoglobulin Secretion Plasma Cell Differentiation Xbp1 mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • R. Sciammas
    • 1
  • M. M. Davis
    • 2
  1. 1.Department of Molecular Genetics and Cell BiologyUniversity of ChicagoChicagoUSA
  2. 2.Department of Microbiology and Immunology and the Howard Hughes Medical InstituteStanford University School of MedicineStanfordUSA

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