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The pre-B cell Receptor in B Cell Development: Recent Advances, Persistent Questions and Conserved Mechanisms

  • M. R. Clark
  • A. B. Cooper
  • L. D. Wang
  • I. Aifantis
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 290)

Abstract

B cell development is a process tightly regulated by the orchestrated signaling of cytokine receptors, the pre-B cell receptor (BCR) and the B cell receptor (BCR). It commences with common lymphoid progenitors (CLP) up-regulating the expression of B cell-related genes and committing to the B cell lineage. Cytokine signaling (IL-7, stem cell factor, FLT3-L) is essential at this stage of development as it suppresses cell death, sustains proliferation and facilitates heavy chain rearrangements. As a result of heavy chain recombination, the pre-BCR is expressed, which then becomes the primary determiner of survival, cell cycle entry and allelic exclusion. In this review, we discuss the mechanisms of B cell lineage commitment and describe the signaling pathways that are initiated by the pre-BCR. Finally, we compare pre-BCR and pre-TCR structure, signal transduction and function, drawing parallels between early pre-B and pre-T cell development.

Keywords

Allelic Exclusion Common Lymphoid Progenitor TCRb Chain Surrogate Light Chain Heavy Chain Rearrangement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • M. R. Clark
    • 1
  • A. B. Cooper
    • 1
  • L. D. Wang
    • 1
  • I. Aifantis
    • 1
  1. 1.Section of RheumatologyUniversity of ChicagoChicagoUSA

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