Helix-Loop-Helix Proteins in Lymphocyte Lineage Determination

  • B. L. Kee
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 290)


The cells of the lymphoid system develop from multipotent hematopoietic stem cells through a series of intermediate progenitors with progressively restricted developmental options. Commitment to a given lymphoid lineage appears to be controlled by numerous transcriptional regulatory proteins that activate lineage-specific gene expression programs and extinguish expression of lineage-inappropriate genes. In this review I discuss the function of transcription factors belonging to the helix-loop-helix protein family in the control of lymphoid cell fate decisions. A model of lymphocyte lineage determination based on the antagonistic activity of transcriptional activating and repressing helix-loop-helix proteins is presented.


Lineage Commitment Multipotent Progenitor Lymphoid Lineage Lymphocyte Lineage Common Lymphoid Progenitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • B. L. Kee
    • 1
  1. 1.Department of PathologyUniversity of ChicagoChicagoUSA

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