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Wnt Signaling in Lymphopoiesis

  • A. Timm
  • R. Grosschedl
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 290)

Abstract

Wnt signaling elicits changes in gene expression and cell physiology through β-catenin and LEF1/TCF proteins. The signal transduction pathway regulates many cellular and developmental processes, including cell proliferation, cell fate decisions and differentiation. In cells that have been stimulated by a Wnt protein, cytoplasmic β-catenin is stabilized and transferred to the nucleus, where it interacts with the nuclear mediators of Wnt signaling, the LEF1/TCF proteins, to elicit a transcriptional response. Loss-of-function and gain-of-function experiments in the mouse have provided insight into the role of this signaling pathway in lymphopoiesis. The self-renewal and maintenance of hematopoietic stem cells is regulated by Wnt signals. Differentiation of T cells and natural killer cells is blocked in the absence of LEF1/TCF proteins, and pro-B cell proliferation is regulated by Wnt signaling.

Keywords

Adenomatous Polyposis Coli Planar Cell Polarity Lymphoid Enhancer Factor Common Myeloid Progenitor Natural Kill Cell Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • A. Timm
    • 1
  • R. Grosschedl
    • 1
    • 2
  1. 1.Gene Center and Institute of BiochemistryUniversity of MunichMunichGermany
  2. 2.Max-Plank-Institute of ImmunobiologyFreiburgGermany

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