Gene Regulatory Networks Orchestrating B Cell Fate Specification, Commitment, and Differentiation

  • K. L. Medina
  • H. Singh
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 290)


The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification, commitment, and differentiation. We review the progress that has been achieved in the identification and characterization of regulatory components of such circuits, including transcription factors, chromatin modifying proteins, and signaling molecules. A comprehensive developmental model is proposed that invokes sequentially acting regulatory networks which dictate the generation of B cells from multipotential hematopoietic progenitors.


Cell Fate Specification Lymphoid Progenitor Light Chain Locus Chromatin Modify Protein Immunoglobulin Heavy Chain Gene Rearrangement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • K. L. Medina
    • 1
  • H. Singh
    • 1
  1. 1.Howard Hughes Medical InstituteThe University of ChicagoChicagoUSA

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