Laser-Induced Thermotherapy

  • Thomas J. Vogl
  • Kathrin Eichler
  • Thomas Lehnert
  • Ralf Straub
  • Martin Mack
Part of the Medical Radiology book series (MEDRAD)


Liver Metastasis Liver Resection Colorectal Liver Metastasis Percutaneous Ethanol Injection LITT Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Adson MA (1987) Resection of liver metastases — when is it worthwhile? World J Surg 11:511–520CrossRefPubMedGoogle Scholar
  2. Adson MA, Heerden van J, Adson MH, et al (1984) Resection of hepatic metastases from colorectal cancer. Arch Surg 119:647–651PubMedGoogle Scholar
  3. Amin Z, Lees WR, Bown SG (1993) Hepatocellular carcinoma: CT appearance after percutaneous ethanol ablation therapy. Radiology 188:882–883PubMedGoogle Scholar
  4. Ardalan B, Sridhar KS, Benedetto P, et al (1991) A phase I, II study of high-dose 5-fluorouracil and high-dose leucovorin with low-dose phosphonacetyl-L-aspartic acid in patients with advanced malignancies. Cancer 68:1242–1246PubMedGoogle Scholar
  5. Ballantyne GH, Quin J (1993) Surgical treatment of liver metastases in patients with colorectal cancer. Cancer 71:4252–4266PubMedGoogle Scholar
  6. Bartolozzi C, Lencioni R (1996) Ethanol injection for the treatment of hepatic tumors. Eur Radiol 6:682–696PubMedGoogle Scholar
  7. Bismuth H, Chiche L, Adam R, et al (1993) Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg 218:145–151PubMedGoogle Scholar
  8. Butler J, Attiyeh FF, Daly JM (1986) Hepatic resection for metastases of the colon and rectum. Surg Gynecol Obstet 162:109–113PubMedGoogle Scholar
  9. Cady B, Stone MD (1991) The role of surgical resection of liver metastases in colorectal carcinoma. Semin Oncol 18:399–406PubMedGoogle Scholar
  10. Charnley RM, Doran J, Morris DL (1989) Cryotherapy for liver metastases: a new approach. Br J Surg 76:1040–1041PubMedGoogle Scholar
  11. De Cobelli F, Castrucci M, Sironi S, et al (1994) Role of magnetic resonance in the follow-up of hepatocarcinoma treated with percutaneous ethanol injection (PEI) or transarterial chemoembolization (TACE). Radiol Med 88:806–817Google Scholar
  12. Doci R, Gennai L, Bignami P, et al (1991) One hundred patients with hepatic metastases from colorectal cancer treated by resection: analysis of prognostics determinants. Br J Surg 78:797–801PubMedGoogle Scholar
  13. Dodd GD, Soulen MC, Kane RA, et al (2000) Minimally invasive treatment of malignant hepatic tumors: at the threshold of a major breakthrough. Radiographics 20:9–27PubMedGoogle Scholar
  14. Douillard JY, Bennouna J, Vavasseur F, et al (2000a) Phase I trial of interleukin-2 and high-dose arginine butyrate in metastatic colorectal cancer. Cancer Immunol Immunother 49:56–61CrossRefPubMedGoogle Scholar
  15. Douillard JY, Cunningham D, Roth AD, et al (2000b) Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 355:1041–1047CrossRefPubMedGoogle Scholar
  16. Finlay IG, Seifert JK, Stewart GJ, et al (2000) Resection with cryotherapy of colorectal hepatic metastases has the same survival as hepatic resection alone. Eur J Surg Oncol 26:199–202CrossRefPubMedGoogle Scholar
  17. Fong Y, Cohen AM, Fortner JG, et al (1997) Liver resection for colorectal metastases. J Clin Oncol 15:938–946PubMedGoogle Scholar
  18. Fong Y, Blumgart LH (1998) Hepatic colorectal metastasis: current status of surgical therapy. Oncology 12:1489–1498; discussion 1498–1500, 1503PubMedGoogle Scholar
  19. Giacchetti S, Itzhaki M, Gruia G, et al (1990) Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. Ann Oncol 10:663–669Google Scholar
  20. Harrison LE, Brennan MF, Newman E, et al (1997) Hepatic resection for noncolorectal, nonneuroendocrine metastases: a fifteen-year experience with ninety-six patients. Surgery 121:625–632CrossRefPubMedGoogle Scholar
  21. Hewitt PM, Dwerryhouse SJ, Zhao J, et al (1998) Multiple bilobar liver metastases: cryotherapy for residuallesions after liver resection. J Surg Oncol 67:112–116CrossRefPubMedGoogle Scholar
  22. Hohenberger P, Schlag P, Schwarz V, et al (1988) Leberresektion bei Patienten mit Metastasen colorektaler Carcinome. Ergebnisse und prognostische Faktoren. Chirurg 59:410–417PubMedGoogle Scholar
  23. Hughes KS, Simon R, Songhorabodi S, et al (1988) Resection of the liver for colorectal carcinoma metastases: A multi-institutional study of indications for resections. Surgery 103:278–288Google Scholar
  24. Jenkins LT, Millikan KW, Bines SD, et al (1997) Hepatic resection for metastatic colorectal cancer. Am Surg 63:605–610PubMedGoogle Scholar
  25. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observation. J Am Stat Assoc 53:457–481Google Scholar
  26. Kawai S, Tani M, Okumura J, et al (1997) Prospective and randomized clinical trial of Lipiodol-transcatheter arterial chemoembolization for treatment of hepatocellular carcinoma: a comparison of Epirubicin and Doxorubicin (Second Cooperative Study). Semin Oncol 24:38–45Google Scholar
  27. Kemeny NE (1995) Regional chemotherapy of colorectal cancer. Eur J Cancer 31A:1271–1276PubMedGoogle Scholar
  28. Kemeny NE, Atiq OT (1999) Non-surgical treatment for liver metastases. Baillieres Best Pract Res Clin Gastroenterol 13:593–610CrossRefPubMedGoogle Scholar
  29. Kemeny NE, Huang Y, Cohen AM, et al (1999) Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. N Engl J Med 341:2039–2048CrossRefPubMedGoogle Scholar
  30. Lin DY, Lin SM, Liaw YF (1997) Non-surgical treatment of hepatocellular carcinoma. J Gastroenterol Hepatol 12:S319–328PubMedGoogle Scholar
  31. Livraghi T, Lazzaroni S, Pellicano S, et al (1993) Percutaneous ethanol injection of hepatic tumors: single-session therapy with general anesthesia. AJR Am J Roentgenol 161:1065–1069PubMedGoogle Scholar
  32. Livraghi T, Giorgio A, Marin G, et al (1995) Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injection. Radiology 197:101–108PubMedGoogle Scholar
  33. Livraghi T, Goldberg SN, Monti F, et al (1997) Saline-enhanced radio-frequency tissue ablation in the treatment of liver metastases. Radiology 202:205–210PubMedGoogle Scholar
  34. Livraghi T, Goldberg SN, Lazzaroni S, et al (1999) Small hepatocellular carcinoma: treatment with radio-frequency ablation versus ethanol injection. Radiology 210:655–661PubMedGoogle Scholar
  35. Livraghi T, Lazzaroni S, Vettori C (1990) Percutaneous ethanol injection of small hepatocellular carcinoma. Rays 15:405–410PubMedGoogle Scholar
  36. Lorenz M, Heinrich S, Staib-Sebler E, et al (2000) Relevance of locoregional chemotherapy in patients with liver metastases from colorectal primaries. Swiss Surg 6:11–22PubMedGoogle Scholar
  37. Lorenz M, Waldeyer M (1997) The resection of the liver metastases of primary colorectal tumors. The development of a scoring system to determine the individual prognosis based on an assessment of 1568 patients. Strahlenther Onkol 173:118–119PubMedGoogle Scholar
  38. Lorenz M, Muller HH (2000) Randomized multicenter trial of fluorouracil plus leucovorin administered either via hepatic arterial or intravenous infusion versus fluoro-deoxyuridine administered via hepatic arterial infusion in patients with nonresectable liver metastases from colorectal carcinoma [see comments]. J Clin Oncol 18:243–254PubMedGoogle Scholar
  39. Lorenz M, Waldeyer M, Muller HH (1996) Comparison of lipiodol-assisted chemoembolization versus only conservative therapy in patients with nonresectable hepatocellular carcinomas. Z Gastroenterol 34:205–206PubMedGoogle Scholar
  40. Maksan SM, Lehnert T, Bastert G, et al (2000) Curative liver resection for metastatic breast cancer. Eur J Surg Oncol 26:209–212CrossRefPubMedGoogle Scholar
  41. Mariette D, Fagniez PL (1992) Hepatic metastasis of noncolorectal cancers. Results of surgical treatment. Rev Prat 42:1271–1275PubMedGoogle Scholar
  42. Nordlinger B, Guiguet M, Vaillant JC, et al (1996) Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Francaise de Chirurgie. Cancer 77:1254–1262CrossRefPubMedGoogle Scholar
  43. Petrelli NJ, Nambisan RN, Herrera L, et al (1985) Hepatic resection for isolated metastasis from colorectal carcinoma. Am J Surg 149:205–208PubMedGoogle Scholar
  44. Ramsey WH, Wu GY (1995) Hepatocellular carcinoma: update on diagnosis and treatment. Dig Dis 13:81–91PubMedGoogle Scholar
  45. Rossi S, Di Stasi M, Buscarini E, et al (1996) Percutaneous RF interstitial thermal ablation in the treatment of hepatic cancer. AJR Am J Roentgenol 167:759–768PubMedGoogle Scholar
  46. Sato M, Watanabe Y, Tokui K, et al (2000) CT-guided treatment of ultrasonically invisible hepatocellular carcinoma. Am J Gastroenterol 95:2102–2106CrossRefPubMedGoogle Scholar
  47. Scheele J, Altendorf-Hofmann A, Stangl R, et al (1996) Surgical resection of colorectal liver metastases: gold standard for solitary and completely resectable lesions. Swiss Surg [Suppl 4]:4–17PubMedGoogle Scholar
  48. Seifert JK, Achenbach T, Heintz A, et al (2000) Cryotherapy for liver metastases. Int J Colorectal Dis 15:161–166CrossRefPubMedGoogle Scholar
  49. Shapiro RS, Shafir M, Sung M, et al (1998) Cryotherapy of metastatic carcinoid tumors. Abdom Imaging 23:314–317CrossRefPubMedGoogle Scholar
  50. Shiina S, Tagawa K, Unama T, et al (1990) Percutaneous ethanol injection therapy of hepatocellular carcinoma: Analysis of 77 patients. AJR Am J Roentgenol 155:1221–1226PubMedGoogle Scholar
  51. Sironi S, Livraghi T, Del Maschio A (1991) Small hepatocellular carcinoma treated with percutaneous ethanol injection: MR imaging findings. Radiology 180:333–336PubMedGoogle Scholar
  52. Solbiati L, Goldberg SN, Ierace T, et al (1997) Hepatic metastases: percutaneous radiofrequency ablation with cooled-tip electrodes. Radiology 205:367–373PubMedGoogle Scholar
  53. Stangl R, Altendorf Hofmann A, Charnley RM,et al (1994) Factors influencing the natural history of colorectal liver metastases. Lancet 343:1405–1410CrossRefPubMedGoogle Scholar
  54. Vogl TJ, Mack MG, Roggan A (2000a) Magnetresonanztomographisch gesteuerte laserinduzierte Thermotherapie von Lebermetastasen. Deutsches Ärzteblatt 37:B2039–2044Google Scholar
  55. Vogl TJ, Mack MG, Straub R (2000b) Perkutane interstitielle Thermotherapie maligner Lebertumoren. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 172:12–22PubMedGoogle Scholar
  56. Vogl TJ, Trapp M, Schroeder H (2000c) Transarterial chemoembolization for hepatocellular carcinoma: volumetric and morphologic CT criteria for assessment of prognosis and therapeutic success-results from a liver transplantation center. Radiology 214:349–357PubMedGoogle Scholar
  57. Vogl TJ, Straub R, Eichler K, et al (2002) Malignant liver tumors treated with MR imaging-guided laser-induced thermotherapy: experience with complications in 899 patients (2,520 lesions). Radiology 225:367–377PubMedGoogle Scholar
  58. Vogl TJ, Mack MG, Balzer J, et al (2003) Liver metastases: neoadjuvant downsizing with transarterial chemoem-bolization before laser-induced thermotherapy. Radiology 229:457–464PubMedGoogle Scholar
  59. Vogl TJ, Straub R, Eichler K, et al (2004) Colorectal carcinoma metastases in liver: laser-induced interstitial thermotherapy — local tumor control rate and survival data. Radiology 230:450–458PubMedGoogle Scholar
  60. Wang SS, Vander Brink BA, Regan J, et al (2000) Microwave radiometric thermometry and its potential applicability to ablative therapy. J Interv Card Electrophysiol 4:295–300PubMedGoogle Scholar
  61. Weiss L (1994) Inefficiency of metastasis from colorectal carcinomas. Relationship to local therapy for hepatic metastasis. Cancer Treat Res 69:1–11PubMedGoogle Scholar
  62. Weiss L, Grundmann E, Torhorst J, et al (1986) Haematogenous metastatic patterns in colonic carcinoma: an analysis of 1541 necropsies. J Pathol 150:195–203CrossRefPubMedGoogle Scholar
  63. Yoon SS, Tanabe KK (1999) Surgical treatment and other regional treatments for colorectal cancer liver metastases. Oncologist 4:197–208PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Thomas J. Vogl
    • 1
  • Kathrin Eichler
    • 1
  • Thomas Lehnert
    • 1
  • Ralf Straub
    • 1
  • Martin Mack
    • 1
  1. 1.Department of Diagnostic and Interventional RadiologyUniversity Hospital FrankfurtFrankfurt/MainGermany

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