The Role of Diet, Physical Activity and Body Composition in Cancer Prevention

  • Cynthia A. Thomson
  • Zhao Chen
  • Robert B. Lutz


Breast Cancer Physical Activity Bone Mineral Density Body Composition Androgen Deprivation Therapy 


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  1. (1994). "Aetiology of testicular cancer: association with congenital abnormalities, age at puberty, infertility, and exercise. United Kingdom Testicular Cancer Study Group." Bmj 308(6941): 1393–1399.Google Scholar
  2. (2004). "Diagnosis of osteoporosis in men, premenopausal women, and children." J Clin Densitom 7(1): 17–26.Google Scholar
  3. ACS (2003). Cancer Facts and Figures, 2003. Atlanta, American Cancer Society.Google Scholar
  4. Alberts, D.S., M. E. Martinez, et al. (2000). "Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians' Network." N Engl J Med 342(16): 1156–1162.Google Scholar
  5. Ames, B.N. (1983). "Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases." Science 221(4617): 1256–1264.PubMedGoogle Scholar
  6. Basaria, S., J. Lieb, 2nd, et al. (2002). "Long-term effects of androgen deprivation therapy in prostate cancer patients." Clin Endocrinol (Oxf) 56(6): 779–786.CrossRefGoogle Scholar
  7. Berruti, A., L. Dogliotti, et al. (2002). "Changes in bone mineral density, lean body mass and fat content as measured by dual energy x-ray absorptiometry in patients with prostate cancer without apparent bone metastases given androgen deprivation therapy." J Urol 167(6): 2361–2367; discussion 2367.CrossRefPubMedGoogle Scholar
  8. Bingham, S.A., N.E. Day, et al. (2003). "Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study." Lancet 361(9368): 1496–1501.CrossRefPubMedGoogle Scholar
  9. Boule, N.G., E. Haddad, et al. (2001). "Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials." Jama 286(10): 1218–1227.CrossRefPubMedGoogle Scholar
  10. Brown, J.K., T. Byers, et al. (2003). "Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices." CA Cancer J Clin 53(5): 268–291.PubMedGoogle Scholar
  11. Byers, T., M. Nestle, et al. (2002). "American Cancer Society guidelines on nutrition and physical activity for cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity." CA Cancer J Clin 52(2): 92–119.PubMedGoogle Scholar
  12. Chen, H.H., B.F. Lee, et al. (2002). "Changes in bone mineral density of lumbar spine after pelvic radiotherapy." Radiother Oncol 62(2): 239–242.CrossRefPubMedGoogle Scholar
  13. Chen, Z., M. Maricic, et al. (2002). "Low bone density and high percentage of body fat among men who were treated with androgen deprivation therapy for prostate carcinoma." Cancer 95(10): 2136–2144.CrossRefPubMedGoogle Scholar
  14. Chen, Z., M. Maricic, et al. (in press, 2005). "Fracture risk among breast cancer survivors: results from the Women's Health Initiative observational study." Arch Int Med.Google Scholar
  15. Clarke, G. and A.S. Whittemore (2000). "Prostate cancer risk in relation to anthropometry and physical activity: the National Health and Nutrition Examination Survey I Epidemiological Follow-Up Study." Cancer Epidemiol Biomarkers Prev 9(9): 875–881.PubMedGoogle Scholar
  16. Coggon, D., B. Pannett, et al. (1986). "A survey of cancer and occupation in young and middle aged men. II. Non-respiratory cancers." Br J Ind Med 43(6): 381–386.PubMedGoogle Scholar
  17. Coleman, R. E. (2001). "Metastatic bone disease: clinical features, pathophysiology and treatment strategies." Cancer Treat Rev 27(3): 165–176.CrossRefPubMedGoogle Scholar
  18. Collins, A. and V. Harrington (2002). "Repair of oxidative DNA damage: assessing its contribution to cancer prevention." Mutagenesis 17(6): 489–493.CrossRefPubMedGoogle Scholar
  19. Courneya, K.S. (2003). "Exercise in cancer survivors: an overview of research." Med Sci Sports Exerc 35(11): 1846–1852.PubMedGoogle Scholar
  20. Courneya, K.S., J.R. Mackey, et al. (2003). "Randomized controlled trial of exercise training in postmenopausal breast cancer survivors: cardiopulmonary and quality of life outcomes." J Clin Oncol 21(9): 1660–1668.CrossRefPubMedGoogle Scholar
  21. Demark-Wahnefried, W., B.K. Rimer, et al. (1997). "Weight gain in women diagnosed with breast cancer." J Am Diet Assoc 97(5): 519–526, 529; quiz 527–528.CrossRefPubMedGoogle Scholar
  22. Demark-Wahnefried, W., E. P. Winer, et al. (1993). "Why women gain weight with adjuvant chemotherapy for breast cancer." J Clin Oncol 11(7): 1418–1429.PubMedGoogle Scholar
  23. den Tonkelaar, I., F. de Waard, et al. (1995). "Obesity and subcutaneous fat patterning in relation to survival of postmenopausal breast cancer patients participating in the DOM-project." Breast Cancer Res Treat 34(2): 129–137.CrossRefPubMedGoogle Scholar
  24. DHHS (2004). Bone Health and Osteoporosis: A Report of the Surgeon General. Rockville, U.S. Department of Health and Human Services, Office of the Surgeon General.Google Scholar
  25. Dixon, J.K., D.A. Moritz, et al. (1978). "Breast cancer and weight gain: an unexpected finding." Oncol Nurs Forum 5(3): 5–7.Google Scholar
  26. Djuric, Z., J.B. Depper, et al. (1998). "Oxidative DNA damage levels in blood from women at high risk for breast cancer are associated with dietary intakes of meats, vegetables, and fruits." J Am Diet Assoc 98(5): 524–528.CrossRefPubMedGoogle Scholar
  27. Djuric, Z., L.K. Heilbrun, et al. (1991). "Effects of a low-fat diet on levels of oxidative damage to DNA to human peripheral nucleated blood cells." J Natl Cancer Inst 83(11): 766–769.PubMedGoogle Scholar
  28. Doll, R. and R. Peto (1981). "The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today." J Natl Cancer Inst 66(6): 1191–1308.PubMedGoogle Scholar
  29. Douchi, T., S. Kosha, et al. (1997). "Predictors of bone mineral loss in patients with ovarian cancer treated with anticancer agents." Obstet Gynecol 90(1): 12–15.CrossRefPubMedGoogle Scholar
  30. Dreher, D. and A. F. Junod (1996). "Role of oxygen free radicals in cancer development." Eur J Cancer 32A(1): 30–38.CrossRefPubMedGoogle Scholar
  31. Freedson, P.S. and K. Miller (2000). "Objective monitoring of physical activity using motion sensors and heart rate." Res Q Exerc Sport 71(2 Suppl): S21–29.PubMedGoogle Scholar
  32. Ganz, P.A., C.C. Schag, et al. (1987). "Rehabilitation needs and breast cancer: the first month after primary therapy." Breast Cancer Res Treat 10(3): 243–253.CrossRefPubMedGoogle Scholar
  33. Giovannucci, E., A. Ascherio, et al. (1995). "Physical activity, obesity, and risk for colon cancer and adenoma in men." Ann Intern Med 122(5): 327–334.PubMedGoogle Scholar
  34. Goodwin, P.J., M. Ennis, et al. (1999). "Adjuvant treatment and onset of menopause predict weight gain after breast cancer diagnosis." J Clin Oncol 17(1): 120–129.PubMedGoogle Scholar
  35. Hackney, A.C., C. L. Fahrner, et al. (1998). "Basal reproductive hormonal profiles are altered in endurance trained men." J Sports Med Phys Fitness 38(2): 138–141.PubMedGoogle Scholar
  36. Halliwell, B. (2002). "Effect of diet on cancer development: is oxidative DNA damage a biomarker?" Free Radic Biol Med 32(10): 968–974.CrossRefPubMedGoogle Scholar
  37. Headley, J.A., R.L. Theriault, et al. (1998). "Pilot study of bone mineral density in breast cancer patients treated with adjuvant chemotherapy." Cancer Invest 16(1): 6–11.PubMedGoogle Scholar
  38. Heasman, K.Z., H.J. Sutherland, et al. (1985). "Weight gain during adjuvant chemotherapy for breast cancer." Breast Cancer Res Treat 5(2): 195–200.CrossRefPubMedGoogle Scholar
  39. IARC (2002). Overweight and lack of exercise. International Agency for Research on Cancer Handbook of Cancer Prevention.Google Scholar
  40. ICSD (2004). "Technical standardization for dual-energy x-ray absorptiometry." J Clin Densitom 7(1): 27–36.Google Scholar
  41. Irwin, M. L. and B. E. Ainsworth (2004). "Physical activity interventions following cancer diagnosis: methodologic challenges to delivery and assessment." Cancer Invest 22(1): 30–50.CrossRefGoogle Scholar
  42. Kampert, J.B., S. N. Blair, et al. (1996). "Physical activity, physical fitness, and all-cause and cancer mortality: a prospective study of men and women." Ann Epidemiol 6(5): 452–457.CrossRefPubMedGoogle Scholar
  43. Key, T.J., A. Schatzkin, et al. (2004). "Diet, nutrition and the prevention of cancer." Public Health Nutr 7(1A): 187–200.CrossRefPubMedGoogle Scholar
  44. King, M.C., J.H. Marks, et al. (2003). "Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2." Science 302(5645): 643–646.CrossRefPubMedGoogle Scholar
  45. Kritchevsky, D. (1999). "Caloric restriction and experimental carcinogenesis." Toxicol Sci 52(2 Suppl): 13–16.PubMedGoogle Scholar
  46. Kumar, N.B., A. Cantor, et al. (2000). "Android obesity at diagnosis and breast carcinoma survival: Evaluation of the effects of anthropometric variables at diagnosis, including body composition and body fat distribution and weight gain during life span, and survival from breast carcinoma." Cancer 88(12): 2751–2757.CrossRefPubMedGoogle Scholar
  47. La Vecchia, C. (2001). "Diet and human cancer: a review." Eur J Cancer Prev 10(2): 177–181.CrossRefPubMedGoogle Scholar
  48. Lee, I.M. and R.S. Paffenbarger, Jr. (1994). "Physical activity and its relation to cancer risk: a prospective study of college alumni." Med Sci Sports Exerc 26(7): 831–837.PubMedGoogle Scholar
  49. Lee, I.M., R.S. Paffenbarger, Jr., et al. (1991). "Physical activity and risk of developing colorectal cancer among college alumni." J Natl Cancer Inst 83(18): 1324–1329.PubMedGoogle Scholar
  50. Lee, I.M., H.D. Sesso, et al. (1999). "Physical activity and risk of lung cancer." Int J Epidemiol 28(4): 620–625.CrossRefPubMedGoogle Scholar
  51. LeRoith, D., R. Baserga, et al. (1995). "Insulin-like growth factors and cancer." Ann Intern Med 122(1): 54–59.PubMedGoogle Scholar
  52. Liedman, B. (1999). "Symptoms after total gastrectomy on food intake, body composition, bone metabolism, and quality of life in gastric cancer patients — is reconstruction with a reservoir worthwhile?" Nutrition 15(9): 677–682.CrossRefPubMedGoogle Scholar
  53. Liedman, B., A. Henningsson, et al. (2000). "Changes in bone metabolism and body composition after total gastrectomy: results of a longitudinal study." Dig Dis Sci 45(4): 819–824.CrossRefPubMedGoogle Scholar
  54. Liu, S., I.M. Lee, et al. (2000). "A prospective study of physical activity and risk of prostate cancer in US physicians." Int J Epidemiol 29(1): 29–35.CrossRefPubMedGoogle Scholar
  55. Lucia, A., J.L. Chicharro, et al. (1996). "Reproductive function in male endurance athletes: sperm analysis and hormonal profile." J Appl Physiol 81(6): 2627–2636.PubMedGoogle Scholar
  56. Margaritis, I., F. Tessier, et al. (1997). "No evidence of oxidative stress after a triathlon race in highly trained competitors." Int J Sports Med 18(3): 186–190.PubMedGoogle Scholar
  57. Maricic, M. and Z. Chen (2000). "Bone densitometry." Clin Lab Med 20(3): 469–488.PubMedGoogle Scholar
  58. Martinez, M.E., E. Giovannucci, et al. (1997). "Leisure-time physical activity, body size, and colon cancer in women. Nurses' Health Study Research Group." J Natl Cancer Inst 89(13): 948–955.CrossRefPubMedGoogle Scholar
  59. Mazzeo, R.S. (1994). "The influence of exercise and aging on immune function." Med Sci Sports Exerc 26(5): 586–592.PubMedGoogle Scholar
  60. Mincey, B.A., T.J. Moraghan, et al. (2000). "Prevention and treatment of osteoporosis in women with breast cancer." Mayo Clin Proc 75(8): 821–829.PubMedGoogle Scholar
  61. Mink, P.J., A.R. Folsom, et al. (1996). "Physical activity, waist-to-hip ratio, and other risk factors for ovarian cancer: a follow-up study of older women." Epidemiology 7(1): 38–45.PubMedGoogle Scholar
  62. Montoye, H.J., H.C.G. Kemper, et al. (1996). Measuring Physical Activity and Energy Expenditure. Champaign, Human Kinetics.Google Scholar
  63. NASPE (2004). Physical Activity for Children: A Statement of Guidelines for Children Ages 5–12. Reston, NASPE Publications.Google Scholar
  64. Nelson, M.E., C.N. Meredith, et al. (1988). "Hormone and bone mineral status in endurance-trained and sedentary postmenopausal women." J Clin Endocrinol Metab 66(5): 927–933.PubMedGoogle Scholar
  65. Newsholme, E.A., Parry-Billings, M. (1994). Effects of exercise on the immune system. Physical Activity, Fitness and Health: International Proceedings Consensus Statement. C. Bouchard, Shephard, R.J., Stephens, T. Champaign, Human Kinetics.Google Scholar
  66. Oliveria, S.A. and I.M. Lee (1997). "Is exercise beneficial in the prevention of prostate cancer?" Sports Med 23(5): 271–278.PubMedGoogle Scholar
  67. Pfeilschifter, J. and I.J. Diel (2000). "Osteoporosis due to cancer treatment: pathogenesis and management." J Clin Oncol 18(7): 1570–1593.PubMedGoogle Scholar
  68. Pierce, J.P., S. Faerber, et al. (2002). "A randomized trial of the effect of a plant-based dietary pattern on additional breast cancer events and survival: the Women's Healthy Eating and Living (WHEL) Study." Control Clin Trials 23(6): 728–756.CrossRefPubMedGoogle Scholar
  69. Pollock, M.L., G.A. Gaesser, et al. (1998). "American College of Sports Medicine Position Stand. The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults." Med Sci Sports Exerc 30(6): 975–991.CrossRefPubMedGoogle Scholar
  70. Poulsen, H.E., S. Loft, et al. (1996). "Extreme exercise and oxidative DNA modification." J Sports Sci 14(4): 343–346.CrossRefPubMedGoogle Scholar
  71. Quan, M.L., J.L. Pasieka, et al. (2002). "Bone mineral density in well-differentiated thyroid cancer patients treated with suppressive thyroxine: a systematic overview of the literature." J Surg Oncol 79(1): 62–69; discussion 69–70.CrossRefPubMedGoogle Scholar
  72. Riboli, E. and T. Norat (2003). "Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk." Am J Clin Nutr 78(3 Suppl): 559S–569S.PubMedGoogle Scholar
  73. Rockhill, B., W.C. Willett, et al. (1999). "A prospective study of recreational physical activity and breast cancer risk." Arch Intern Med 159(19): 2290–2296.CrossRefPubMedGoogle Scholar
  74. Saarto, T., C. Blomqvist, et al. (1997). "Clodronate improves bone mineral density in postmenopausal breast cancer patients treated with adjuvant antioestrogens." Br J Cancer 75(4): 602–605.PubMedGoogle Scholar
  75. Sarhill, N., D. Walsh, et al. (2000). "Bioelectrical impedance, cancer nutritional assessment, and ascites." Support Care Cancer 8(4): 341–343.CrossRefPubMedGoogle Scholar
  76. Sass, J. (2002). "Lead IARC towards compliance with WHO/IARC Declarations of Interests (DOI) policy." Int J Occup Environ Health 8(3): 277–278.PubMedGoogle Scholar
  77. Schapira, D.V., N.B. Kumar, et al. (1991). "Obesity and body fat distribution and breast cancer prognosis." Cancer 67(2): 523–528.PubMedGoogle Scholar
  78. Schatzkin, A., E. Lanza, et al. (2000). "Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group." N Engl J Med 342(16): 1149–1155.CrossRefPubMedGoogle Scholar
  79. Schwartz, R.S., W. P. Shuman, et al. (1991). "The effect of intensive endurance exercise training on body fat distribution in young and older men." Metabolism 40(5): 545–551.CrossRefPubMedGoogle Scholar
  80. Segal, R., W. Evans, et al. (2001). "Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a randomized controlled trial." J Clin Oncol 19(3): 657–665.PubMedGoogle Scholar
  81. Segal, R.J., R. D. Reid, et al. (2003). "Resistance exercise in men receiving androgen deprivation therapy for prostate cancer." J Clin Oncol 21(9): 1653–1659.CrossRefPubMedGoogle Scholar
  82. Sesso, H.D., R.S. Paffenbarger, Jr., et al. (1998). "Physical activity and breast cancer risk in the College Alumni Health Study (United States)." Cancer Causes Control 9(4): 433–439.CrossRefPubMedGoogle Scholar
  83. Severson, R.K., J.S. Grove, et al. (1988). "Body mass and prostatic cancer: a prospective study." Bmj 297(6650): 713–715.PubMedGoogle Scholar
  84. Shapiro, C.L., J. Manola, et al. (2001). "Ovarian failure after adjuvant chemotherapy is associated with rapid bone loss in women with early-stage breast cancer." J Clin Oncol 19(14): 3306–33011.PubMedGoogle Scholar
  85. Sherman, W. M., D. M. Morris, et al. (1998). "Evaluation of a commercial accelerometer (Tritrac-R3 D) to measure energy expenditure during ambulation." Int J Sports Med 19(1): 43–47.PubMedGoogle Scholar
  86. Simons, J.P., A.M. Schols, et al. (1999). "Weight loss and low body cell mass in males with lung cancer: relationship with systemic inflammation, acute-phase response, resting energy expenditure, and catabolic and anabolic hormones." Clin Sci (Lond) 97(2): 215–223.Google Scholar
  87. Siverston, I., Dahlstrom, A.W (1922). "The relation of muscular activity to carcinoma: a preliminary report." J Cancer Research 6: 365–378.Google Scholar
  88. Smith, G.D., M.J. Shipley, et al. (2000). "Physical activity and cause-specific mortality in the Whitehall study." Public Health 114: 1–8.CrossRefPubMedGoogle Scholar
  89. Smith, M.R. (2002). "Osteoporosis during androgen deprivation therapy for prostate cancer." Urology 60(3 Suppl 1): 79–85; discussion 86.CrossRefPubMedGoogle Scholar
  90. Smith, M.R., F.J. McGovern, et al. (2001). "Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer." N Engl J Med 345(13): 948–955.CrossRefPubMedGoogle Scholar
  91. Steinmetz, K.A. and J.D. Potter (1996). "Vegetables, fruit, and cancer prevention: a review." J Am Diet Assoc 96(10): 1027–1039.CrossRefPubMedGoogle Scholar
  92. Stepan, J.J. (2003). "Clinical utility of bone markers in the evaluation and follow-up of osteoporotic patients: why are the markers poorly accepted by clinicians?" J Endocrinol Invest 26(5): 458–463.PubMedGoogle Scholar
  93. Stoch, S.A., R.A. Parker, et al. (2001). "Bone loss in men with prostate cancer treated with gonadotropin-releasing hormone agonists." J Clin Endocrinol Metab 86(6): 2787–2791.CrossRefPubMedGoogle Scholar
  94. Terry, P., J.A. Baron, et al. (1999). "Lifestyle and endometrial cancer risk: a cohort study from the Swedish Twin Registry." Int J Cancer 82(1): 38–42.CrossRefPubMedGoogle Scholar
  95. Thompson, H.J., J. Heimendinger, et al. (1999). "Effect of increased vegetable and fruit consumption on markers of oxidative cellular damage." Carcinogenesis 20(12): 2261–2266.CrossRefPubMedGoogle Scholar
  96. Thune, I., T. Brenn, et al. (1997). "Physical activity and the risk of breast cancer." N Engl J Med 336(18): 1269–1275.CrossRefPubMedGoogle Scholar
  97. Thune, I. and A.S. Furberg (2001). "Physical activity and cancer risk: dose-response and cancer, all sites and site-specific." Med Sci Sports Exerc 33(6 Suppl): S530–50; discussion S609–610.PubMedGoogle Scholar
  98. Thune, I. and E. Lund (1994). "Physical activity and the risk of prostate and testicular cancer: a cohort study of 53,000 Norwegian men." Cancer Causes Control 5(6): 549–556.CrossRefPubMedGoogle Scholar
  99. USDHHS (1996). Physical Activity and Health: A Report of the Surgeon General. Atlanta, US Dept of Health and Human Services, Centers for Disease Control, National Center for Chronic Disease Prevention and Health Promotion.Google Scholar
  100. van Leeuwen, B.L., W.A. Kamps, et al. (2000). "The effect of chemotherapy on the growing skeleton." Cancer Treat Rev 26(5): 363–376.CrossRefPubMedGoogle Scholar
  101. van Zeeland, A.A., A.J. de Groot, et al. (1999). "8-Hydroxydeoxyguanosine in DNA from leukocytes of healthy adults: relationship with cigarette smoking, environmental tobacco smoke, alcohol and coffee consumption." Mutat Res 439(2): 249–257.PubMedGoogle Scholar
  102. Vehmanen, L., T. Saarto, et al. (2001). "Long-term impact of chemotherapy-induced ovarian failure on bone mineral density (BMD) in premenopausal breast cancer patients. The effect of adjuvant clodronate treatment." Eur J Cancer 37(18): 2373–2378.CrossRefPubMedGoogle Scholar
  103. WCRF Food, Nutrition, and the Prevention of Cancer: A Global Perspective, World Cancer Research Fund.Google Scholar
  104. Wei, G.S., J.L. Jackson, et al. (2003). "Osteoporosis management in the new millennium." Prim Care 30(4): 711–741, vi–vii.PubMedGoogle Scholar
  105. Westerlind, K.C. (2003). "Physical activity and cancer prevention-mechanisms." Med Sci Sports Exerc 35(11): 1834–1840.PubMedGoogle Scholar
  106. Williams, N.I., B.A. Bullen, et al. (1999). "Effects of short-term strenuous endurance exercise upon corpus luteum function." Med Sci Sports Exerc 31(7): 949–958.CrossRefPubMedGoogle Scholar
  107. Zhang, S., A.R. Folsom, et al. (1995). "Better breast cancer survival for postmenopausal women who are less overweight and eat less fat. The Iowa Women's Health Study." Cancer 76(2): 275–283.PubMedGoogle Scholar

Copyright information

© Springer Berlin Heidelberg 2005

Authors and Affiliations

  • Cynthia A. Thomson
    • 1
  • Zhao Chen
    • 1
  • Robert B. Lutz
    • 2
  1. 1.College of Agriculture and Life Sciences and College of Public HealthUniversity of ArizonaTucson
  2. 2.Empire Health SystemsSpokane

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