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Platinum amine coordination compounds as anti-tumor drugs. Molecular aspects of the mechanism of action

  • Jan Reedijk
  • Anne Marie J. Fichtinger-Schepman
  • Allan T. van Oosterom
  • Piet van de Putte
Conference paper
Part of the Structure and Bonding book series (STRUCTURE, volume 67)

Abstract

An overview is presented of platinum amine compounds, used as antitumor drugs. The history of the discovery is briefly described, including a discussion of the synthesis of platinum amine coordination compounds. Attention is given to the relationship between biological activity and structure of the compounds, especially to the nature of the ligands coordinated to platinum. The primary biological event appears to be the interaction with nucleic acids, and therefore the major part of the review is deals with studies of the binding interactions of platinum amine compounds (active and inactive ones) to nucleic acids and nucleic acid fragments. Studies on mononucleic acid fragments have made clear that a strong preference exists for binding at guanine-N7 sites. Studies on oligonucleotides have shown that, when two neighboring guanines are present, chelation of the cis-Pt(NH3)2 unit is strongly favored above all other possibilities. However, binding at neighboring AG-units also occurs readily. Studies on DNA (in vivo and in vitro) have shown that similar bindings occur in DNA and oligonucleotides, and that the DNA is distorted in a similar manner to double-stranded oligonucleotides.

Keywords

Antitumor Drug Platinum Compound Sugar Ring Amine Ligand Nucleic Acid Fragment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Jan Reedijk
    • 1
  • Anne Marie J. Fichtinger-Schepman
    • 2
  • Allan T. van Oosterom
    • 3
  • Piet van de Putte
    • 4
  1. 1.Department of Chemistry, Gorlaeus LaboratoriesLeiden UniversityRA LeidenThe Netherlands
  2. 2.Medical Biological Laboratory, TNOAA RijswijkThe Netherlands
  3. 3.Department of Clinical OncologyLeiden UniversityThe Netherlands
  4. 4.Biochemical LaboratoryLeiden UniversityThe Netherlands

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