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Heparin-containing polymeric materials

  • Nicolai A. Platé
  • Lev I. Valuev
Conference paper
Part of the Advances in Polymer Science book series (POLYMER, volume 79)

Abstract

Methods for preparing heparin-containing polymeric materials by means of ionic and covalent immobilization of heparin on various polymers are surveyed. The data on the biological activity of heparin are discussed as well as the probable mechanisms of thromboresistance enhancement endowed to polymeric materials by this anticoagulant. Some approaches toward an increased efficiency of anticoagulant properties of immobilized heparin are analyzed, and the position of heparin-containing polymers among other biomedical polymers is discussed.

Keywords

Silicone Rubber Platelet Adhesion Anticoagulant Activity Benzalkonium Chloride Covalent Immobilization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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8 References

  1. 1.
    Bokros, J. C.: J. Thorac. Cardiovasc. Surg. 64, 826 (1972)Google Scholar
  2. 2.
    Vacik, M., Kliment, K., Zavadil, M.: J. Biomed. Mater. Res. 1, 313, (1967)Google Scholar
  3. 3.
    Hoffman, A. S., Horbett, T. A., Ratner, B. D.: Ann. N.Y. Acad. Sci. 283, 372 (1977)Google Scholar
  4. 4.
    Leininger, R. I.: CRC Crit. Rev. Bioeng. 1, 333 (1972)Google Scholar
  5. 5.
    Kusserow, B. K., Karrow, R. W.: Trans. Amer. Soc. Artif. Int. Organs 19, 8 (1973)Google Scholar
  6. 6.
    Platé, N. A., In: Polymeric Drugs, N.Y./London: Acad. Press 1970, p. 63Google Scholar
  7. 7.
    Platé, N. A., Valuev, L. I., Al-Nuri, M. A., Egorov, N. S.: Pricl. Biochim. i Microbiol. 13, 673 (1977) (in Russian)Google Scholar
  8. 8.
    Platé, N. A., Valuev, L. I., Baranova, N. A., Al-Nuri, M. A., Egorov, N. S.: Pat. USSR No. 545648, Bul. Izobret. No. 5 (1977) (in Russian)Google Scholar
  9. 9.
    Platé, N. A., Valuev, L. I., Chupov, V. V.: Vysokomol. Soed. 22A, 1963 (1980) (in Russian)Google Scholar
  10. 10.
    Marconi, W., Bartoli, F., Mantovani, E., Pittalis, F., Settembri, L., Cordova, C., Musca, A., Alessandri, C.: Trans. Amer. Soc. Artif. Int. Organs 25, 10 (1979)Google Scholar
  11. 11.
    Gott, V. L., Koepke, D. E., Daggett, R. L., Zarnstorff, W. L., Young, W. P.: Surgery 50, 382 (1961)Google Scholar
  12. 12.
    Panov, V. P., Ovsepyan, A. M.: Chim. Pharm. Zh. 13, 72 (1979) (in Russian)Google Scholar
  13. 13.
    Shen, L. L., Barlow, G. H., Holleman, W. H.: Thromb, Res. 13, 671 (1978)Google Scholar
  14. 14.
    Danishefsky, J., Steiner, H., Bella, A., Triedlanger, A.: J. Biol. Chem. 244, 1741 (1969)Google Scholar
  15. 15.
    Cifonelli, Y. A., King, Y. I.: Carbohyd. Res. 12, 391 (1970)Google Scholar
  16. 16.
    Ulyanov, A. M., Lyapina, L. A.: Uspechi sovrem. Biol. 83, 69 (1977) (in Russian)Google Scholar
  17. 17.
    Fracassini, A., White, C. Y., Hunter, I. C.: FEBS Lett. 32, 116 (1973)Google Scholar
  18. 18.
    Horner, A. A.: J. Biol. Chem. 246, 231 (1971)Google Scholar
  19. 19.
    Yaun, L., Stivala, S. S.: Adv. Exp. Med. Biol. 52, 39 (1975)Google Scholar
  20. 20.
    Cifonelli, Y. A.: Adv. Exp. Med. Biol. 52, 95 (1975)Google Scholar
  21. 21.
    Ebert, C. D., Kim, S. W.: Thromb. Res. 26, 43 (1982)Google Scholar
  22. 22.
    Zubairov, D. M.: Biochimiya svertyvaniya krovi, Moscow, Medicina 1978, p. 152Google Scholar
  23. 23.
    Gently, P. W., Elexander, B.: Biochem. Biophys. Res. Commun. 50, 500 (1973)Google Scholar
  24. 24.
    Kurachi, K., Fujikama, K., Schmer, G., Davie, E. W.: Biochemistry 15, 373 (1976)Google Scholar
  25. 25.
    Palos, L. A.: Haematologia 8, 455 (1974)Google Scholar
  26. 26.
    Aranyi, P., Batke, Y., Machovich, R.: Arch. Biochem. Biophys. 181, 678 (1977)Google Scholar
  27. 27.
    Yamaguchi, S., Hayashi, H., Hamada, F., Nakajima, A.: Biopolymers 23, 995 (1984)Google Scholar
  28. 28.
    Björk, I., Lindahl, U.: Molecul. Cel. Biochem. 48, 161 (1982)Google Scholar
  29. 29.
    Thunberg, L., Bäckström, G., Lindahl, U.: Carbohyd. Res. 100, 393 (1982)Google Scholar
  30. 30.
    Stone, A. L., Beeler, D., Oosta, G., Rosenberg, R. D.: Proc. Nat. Acad. Sci. USA 79, 7190 (1982)Google Scholar
  31. 31.
    Smith, G. F.: Biochem. Biophys. Res. Commun. 77, 111 (1977)Google Scholar
  32. 32.
    Hatton, M. W., Regoeszi, E.: Thromb. Res. 10, 645 (1977)Google Scholar
  33. 33.
    Kudryachov, B. A., Kalishevskaya, T. M., Lyapina, L. A.: Biochimiya 38, 1281 (1973) (in Russian)Google Scholar
  34. 34.
    Kudryashov, B. A., Lyapina, L. A., Ulyanov, A. M.: Biochimiya 42, 451 (1977) (in Russian)Google Scholar
  35. 35.
    Kudryashov, B. A., Ulyanov, A. M., Zhitnikova, E. S.: Dokl. Akad. Nauk SSSR 237, 965 (1977) (in Russian)Google Scholar
  36. 36.
    Choay, J., Petitou, M., Lormeau, J. C., Sinäy, P., Casu, B., Gatti, G.: Biochem. Biophys. Res. Commun. 116, 492 (1983)Google Scholar
  37. 37.
    McDuffe, N. M., Dietrich, C. P., Nader, H. B.: Biopolymers 14, 1473 (1975)Google Scholar
  38. 38.
    Rosenberg, R. D., Jordon, R. E., Favreau, L. V., Lam, L. H.: Biochem. Biophys. Res. Commun. 86, 1319 (1979)Google Scholar
  39. 39.
    Gott, V. L., Whiffen, J. D., Dutton, R. S.: Science 142, 1297 (1963)Google Scholar
  40. 40.
    Sawyer, P. N., Pate, J. M.: Amer. J. Physiol. 175, 103 (1953)Google Scholar
  41. 41.
    Sawyer, P. N., Suckling, E. E., Weselowski, S. A.: Amer. J. Physiol. 198, 1006 (1960)Google Scholar
  42. 42.
    Whiffen, J. D., Gott, V. L.: J. Surg. Res. 5, 51 (1965)Google Scholar
  43. 43.
    Whiffen, J. D.: Trans. Amer. Soc. Artif. Int. Organs 12, 164 (1966)Google Scholar
  44. 44.
    Regelson, W.: J. Polym. Sci. 66, 483 (1979)Google Scholar
  45. 45.
    Whiffen, J. D., Deeckler, D. C.: J. Thorac. Cardiovasc. Surg. 52, 121 (1966)Google Scholar
  46. 46.
    Usdin, V. R., Fourt, L.: J. Biomed. Mater. Res. 3, 69 (1969)Google Scholar
  47. 47.
    Bokros, J. C., Gott, V. L., La Grande, L. D., Fadall, A. M., Vos, K. D., Ramos, M. D.: J. Biomed. Mater. Res. 3, 497 (1969)Google Scholar
  48. 48.
    Fourt, L., Schwartz, A. M., Becker, R. H., Kairinen, E. O.: Interac. Liquids at Solid Subst. 87, 186 (1968)Google Scholar
  49. 49.
    Gott, V. L., Daggett, R. L., Whiffen, J. D., Koepke, D. E., Rowe, G. C., Young, W. P.: J. Thorac. Cardiovasc. Surg. 48, 713 (1964)Google Scholar
  50. 50.
    Valiatham, M. S., Weldon, C. S., Bender, H. W., Topaz, S. R., Gott, V. L.: J. Surg. Res. 8, 197 (1968)Google Scholar
  51. 51.
    Grode, G. A., Falb, R. D., Crowley, J. P.: J. Biomed. Mater. Res., Symp. 3, 77 (1972)Google Scholar
  52. 52.
    Hersh, L. S., Weetall, H. H., Brown, J. W.: J. Biomed. Mater. Res., Symp. 1, 99 (1971)Google Scholar
  53. 53.
    Leininger, R. I., Crowley, J. P., Falb, R. D., Grode, G. A.: Trans. Amer. Soc. Artif. Int. Organs 18, 312 (1972)Google Scholar
  54. 54.
    Najiar, F. B., Gott, V. L.: Surgery 68, 1053 (1970)Google Scholar
  55. 55.
    Bruck, S. D.: Biomat., Med. Dev., Artif. Organs 1, 79 (1973)Google Scholar
  56. 56.
    Rea, W. J., Whitley, D., Eberle, J. W.: Trans. Amer. Soc. Artif. Int. Organs 18, 316 (1972)Google Scholar
  57. 57.
    Eriksson, J. C., Gillberg, G., Lagergren, H.: J. Biomed. Mater. Res. 1, 301 (1967)Google Scholar
  58. 58.
    Lagergren, H., Johansson, L., Eriksson, J. C.: Thoraxchirurgie 12, 172 (1964)Google Scholar
  59. 59.
    Uy, S., Kammermeyer, K.: J. Biomed. Mater. Res. 3, 587 (1969)Google Scholar
  60. 60.
    Mobin-Uddin, K., Trinkle, K. J., Bryant, L. R.: Surgery 70, 914 (1971)Google Scholar
  61. 61.
    Mobin-Uddin, K., Utley, J. R., Bryant, L. R., Dillon, M., Weiss, D. L.: Ann. Thorac. Surg. 17, 351 (1974)Google Scholar
  62. 62.
    Stewart, G. P., Wilkov, M. A.: J. Biomed. Mater. Res. 10, 413 (1976)Google Scholar
  63. 63.
    Leininger, R. I., Cooper, C. W., Epstein, M. M., Falb, R. D., Grode, G. A.: Science 152, 1625 (1966)Google Scholar
  64. 64.
    Falb, R. D., Leininger, R. I., Grode, G. A., Crowley, J.: Edv. Exp. Med. Biol. 52, 365 (1975)Google Scholar
  65. 65.
    Falb, R. D., Grode, G. A., Takahachi, M. T., Leininger, R. I.: Interac. Liquid at Solid Substr. 87, 181 (1968)Google Scholar
  66. 66.
    Hollahan, J. R., Stafford, B. B., Falb, R. D., Payne, S. T.: J. Appl. Polym. Sci. 13, 807 (1969)Google Scholar
  67. 67.
    Linton, A. C., Gilchrist, T., Courtney, J., Edwards, R. O.: J. Lab. Clin. Med. 89, 724 (1977)Google Scholar
  68. 68.
    Tanzawa, H., Mori, Y., Horumiya, M., Miyama, H., Hori, M., Ohshima, N., Idezuki, Y.: Trans. Amer. Soc. Artif. Int. Organs 19, 188 (1973)Google Scholar
  69. 69.
    Idezuki, Y., Watanabe, H., Hagiwara, M., Kanasugi, H., Mori, Y., Nagaoka, S., Hagio, M., Yamamoto, K., Tanzawa, H.: Trans. Amer. Soc. Artif. Int. Organs 21, 436 (1975)Google Scholar
  70. 70.
    Miyama, H., Harumiya, N., Mori, Y., Tanzawa, H.: J. Biomed. Mater. Res. 11, 251 (1977)Google Scholar
  71. 71.
    Mori, Y., Nagaoka, S., Masubuchi, Y., Itoga, M., Tanzawa, H., Kikuchi, T., Yamada, Y., Yonaha, T., Watanabe, H., Idezuki, Y.: Trans. Amer. Soc. Artif. Int. Organs 24, 736 (1978)Google Scholar
  72. 72.
    Mori, Y., Nagaoka, S., Itoga, M., Tanzawa, H., Yamada, Y., Watanabe, H., Idezuki, Y.: Artif. Organs 2 (Suppl.), 66 (1978)Google Scholar
  73. 73.
    Mori, Y., Nagaoka, S., Tanzawa, H., Kikuchi, T., Yamada, Y., Hagawara, M., Idezuki, Y.: J. Biomed. Mater. Res. 16, 17 (1982)Google Scholar
  74. 74.
    Mori, Y., Nagaoka, S., Kikuchi, T., Tanzawa, H.: J. Biomed. Mater. Res. 16, 209 (1982)Google Scholar
  75. 75.
    Mori, Y., Nagaoka, S., Kikuchi, T., Tanzawa, H.: Artif. Organs 9, 228 (1980) (in Japanese)Google Scholar
  76. 76.
    Merker, R. L., Eliash, L. J., Mayhew, S. H., Wang, J. Y. C.: Artificial Heart Program Conference Proceedings. Ed. Hegyeli, R. J., Washington: National Heart Institute Artificial Heart Program 1969 p. 29Google Scholar
  77. 77.
    Herch, L. S., Weetall, H. H., Brown, I. W.: J. Biomed. Mater. Res. 3, 471 (1969)Google Scholar
  78. 78.
    Bruck, S. D., Rabin, S., Ferguson, R. J.: Biomat. Med. Dev., Artif. Organs 1, 191 (1973)Google Scholar
  79. 79.
    Rittenhouse, E. A., Mohri, H., Reichenbach, D. D., Merendino, K. A.: Arch. Surg. 105, 752 (1972)Google Scholar
  80. 80.
    Merrill, E. W., Salzman, E. W., Lipps, B. J., Gilliland, E. R., Austen, W. G., Joison, J.: Trans. Amer. Soc. Artif. Int. Organs 12, 139 (1966)Google Scholar
  81. 81.
    Halpern, B. D., Shibakawa, R.: Interac. Liquid at Solid Substr. 87, 197 (1968)Google Scholar
  82. 82.
    Palma, M., Riva, F., Provensale, C.: J. Polym. Sci. 15, 2151 (1977)Google Scholar
  83. 83.
    Ferruti, P., Casini, G., Tempesti, F., Barbucci, R., Mastacchi, R., Sarret, M.: Biomaterials 5, 234 (1984)Google Scholar
  84. 84.
    Ferruti, P., Barbucci, R., Danzo, N., Torrisi, A., Puglisi, O., Pignataro, S., Spartano, P.: Biomaterials 3, 33 (1982)Google Scholar
  85. 85.
    Mangano, D. T.: The New England J. of Med. 894 (1982)Google Scholar
  86. 86.
    Pusineri, C., Eloy, R., Baguet, J., Paul, J., Belleville, J., Leconte, P., Farges, J. P.: Artif. Organs 5 (Suppl.), 512 (1981)Google Scholar
  87. 87.
    Hecker, J. F.: Pediatrics 4, 467 (1981)Google Scholar
  88. 88.
    Merrill, E. W., Salzman, E. W., Wong, P. S. L., Ashford, T. P., Brown, A. D., Austen, W. G.: J. Appl. Physiol. 29, 723 (1970)Google Scholar
  89. 89.
    Cholakis, C. H., Sefton, M. V.: ACS Polymer Preprints 24, 64 (1983)Google Scholar
  90. 90.
    Sefton, M. V., Merrill, E. W.: J. Biomed. Mater. Res. 10, 33 (1976)Google Scholar
  91. 91.
    Novikova, S. P.: Abstracts of 4 Vsecoyuznogo Symposiuma po Medicinskim Polymeram, Dzerzhinsk, SSSR, p. 42 (1979)Google Scholar
  92. 92.
    Labarre, D., Boffa, M. C., Jozefowicz, M.: J. Polym. Sci., Symp. 47, 131 (1974)Google Scholar
  93. 93.
    Labarre, D., Boffa, M. C., Jozefowicz, M.: J. Biomed. Mater. Res. 11, 283 (1977)Google Scholar
  94. 94.
    Labarre, D., Boffa, M. C., Jozefowicz, M.: Thromb. and Haemost. 41, 346 (1979)Google Scholar
  95. 95.
    Baquey, Ch., Beziade, A., Ducassou, D., Blanquet, P.: INnov. Tech. Biol. Med. 2(4), 379 (1981)Google Scholar
  96. 96.
    Schmer, G.: Trans. Amer. Soc. Artif. Int. Organs 18, 321 (1972)Google Scholar
  97. 97.
    Danishefsky, J., Tzeng, F., Ahrens, M., Klein, S.: Thromb. Res. 8, 131 (1976)Google Scholar
  98. 98.
    Hoffman, A. S., Schmer, G., Harris, C., Kraft, W. G.: Trans. Amer. Soc. Artif. Int. Organs 18, 10 (1972)Google Scholar
  99. 99.
    Heyman, P. W., Cho, C. S., McRea, J. C., Olsen, D. B., Kim, S. W.: J. Biomed. Mater. Res. (in press)Google Scholar
  100. 100.
    Miura, Y., Aoyagi, S., Kusada, Y., Miyamoto, K.: J. Biomed. Mater. Res. 14, 619 (1980)Google Scholar
  101. 101.
    Platé, N. A., Valuev, L. I., Gumirova, F. Kh.: Dokl. Akad. Nauk SSSR 244, 1505 (1979) (in Russian)Google Scholar
  102. 102.
    Platé, N. A., Valuev, L. I., Gumirova, F. Kh.: Abstracts of 26 International Symposium on Macromolecules, Mainz, 1979, Vol. 3, p. 1522Google Scholar
  103. 103.
    Mester, L., Amit-Amaya, A., Mester, M.: Amer. Chem. Soc., Symp. Ser. 77, 113 (1978)Google Scholar
  104. 104.
    Platé, N. A., Valuev, L. I.: Bullet. Exper. Biol. i Medic. 12, 686 (1981) (in Russian)Google Scholar
  105. 105.
    Platé, N. A., Valuev, L. I., Gumirova, F. Kh., Zimin, N. K., Rozenfeld, M. A.: Voprosy Med. Chimii 28, 97 (1982) (in Russian)Google Scholar
  106. 106.
    Platé, N. A., Valuev, L. I., Gumirova, F. Kh., Maklakova, I. A.: Voprosy Med. Chimii 28, 19 (1982) (in Russian)Google Scholar
  107. 107.
    Platé, N. A., Valuev, L. I.: Thromb. Res. 27, 131 (1982)Google Scholar
  108. 108.
    Platé, N. A., Valuev, L. I.: Biomaterials 4, 14 (1983)Google Scholar
  109. 109.
    Larsson, R., Rosenberg, A., Per Olsson, P.: Thromb. Res. 11, 517 (1977)Google Scholar
  110. 110.
    Essien, E. M., Cazenava, J.-P., Moore, S., Mustard, J. E.: Thromb. Res. 13, 69 (1978)Google Scholar
  111. 111.
    Salzman, E. W., Merrill, E. W., Binder, A., Wole, C. F. W., Ashford, T. P., Austen, W. G.: J. Biomed. Mater. Res. 3, 69 (1969)Google Scholar
  112. 112.
    Goosen, M. F., Sefton, M. V.: J. Biomed. Mater. Res. 13, 347 (1979)Google Scholar
  113. 113.
    Heyman, P. W., Kim, S. W.: Makromol. Chemie (in press)Google Scholar
  114. 114.
    Noishiki, Y.: Proc. 2-nd Jap. Biomater. Soc. 65, 112 (1980) (in Japanese)Google Scholar
  115. 115.
    Ehrlich, J.: Polymer. Eng. and Sci. 15, 281 (1975)Google Scholar
  116. 116.
    Rozenfeld, M. A.: Dokl. Akad. Nauk SSSR 239, 207 (1978) (in Russian)Google Scholar
  117. 117.
    Chepurov, A. K., Belomestnaya, T. M., Donezcy, Yu. A., Cidvinceva, G. A.: Bull. Exper. Biol. i Medic. 5, 296 (1980) (in Russian)Google Scholar
  118. 118.
    Nordenman, B., Björk, J.: Thromb. Res. 11, 799 (1977)Google Scholar
  119. 119.
    Nordenman, B., Björk, J.: Thromb. Res. 12, 755 (1978)Google Scholar
  120. 120.
    Gitel, S. N.: Advans. Exp. Med. Biol. 52, 243 (1975)Google Scholar
  121. 121.
    Platé, N. A., Valuev, L. I.: Abstracts of 5 Vsesoyuznogo Symposiuma po medicinskim polymeram, Riga, USSR, 1981, p. 127 (in Russian)Google Scholar
  122. 122.
    Carlström, A.-S., Lieden, K., Björk, J.: Thromb. Res. 11, 785 (1977)Google Scholar
  123. 123.
    Goosen, M. F. A., Sefton, M. V.: J. Biomed. Mater. Res. 17, 359 (1983)Google Scholar
  124. 124.
    Sun, A. M., Parisius, W., Macmorine, H. G., Sefton, M. V., Stone, R.: Artif. Organs 4, 275 (1980)Google Scholar
  125. 125.
    Goosen, M. F. A., Sefton, M. V., Hatton, M. W. C.: Thromb. Res. 20, 543 (1981)Google Scholar
  126. 126.
    Lindsay, R. M., Rourke, J. T. B., Reid, B. D., Linton, A. L., Gilchrist, T., Courtney, Y., Edwards, R. O.: J. Lab. Clin. Med. 89, 724 (1977)Google Scholar
  127. 127.
    Gott, V. L., Whiffen, J. D., Koepke, D. K., Daggett, R. L., Boake, W. C., Young, W. P.: Trans. Amer. Soc. Artif. Int. Organs 10, 213 (1964)Google Scholar
  128. 128.
    Kudryashov, B. A., Kalishevskaya, T. M., Polyakova, L. A.: Voprosy Med. Chimii 12, 114 (1966) (in Russian)Google Scholar
  129. 129.
    Kudryashov, B. A., Kalishevskaya, T. M., Lyapina, L. A.: Voprosy Med. Chimii 14, 277 (1968) (in Russian)Google Scholar
  130. 130.
    Ulyanov, A. M., Kudryashov, B. A., Lyapina, L. A.: Biochimiya 38, 1281 (1973) (in Russian)Google Scholar
  131. 131.
    Kudryashov, B. A., Lyapina, L. A.: Voprosy Med. Chimii 21, 165 (1975) (in Russian)Google Scholar
  132. 132.
    Shumakov, V. I., Chepurov, A. K.: Cardiologiya, 2, 88 (1972) (in Russian)Google Scholar
  133. 133.
    Grigoryan, A. V., Gostincev, V. K., Panshin, N. N.: Chirurgiya 2, 65 (1971) (in Russian)Google Scholar
  134. 134.
    Struchkov, V. I., Gostincev, V. K.: Aktualnye Problemy Gemostaziologii, Moscow: Nauka 1981, p. 371 (in Russian)Google Scholar
  135. 135.
    Kusserow, B. K., Larrow, R., Nickols, J.: Trans. Amer. Soc. Artif. Int. Organs 17, 1 (1971)Google Scholar
  136. 136.
    Valuev, L. I., Chupov, V. V., Burdygina, I. F.: Abstracts of 4 Vsesoyuznogo Symposiuma po Inzhenernoj Enzim., Kiev, USSR, 1983, p. 88 (in Russian)Google Scholar
  137. 137.
    Platé, N. A., Valuev, L. I., Chupov, V. V.: Pure Appl. Chem. 56, 1351 (1984)Google Scholar
  138. 138.
    Olsson, P., Lagergren, H., Larsson, R., Radegran, K.: Thromb. Haemostas. 37, 274 (1977)Google Scholar
  139. 139.
    Kim, S. W., Lee, R. D., Coleman, D., Oster, H., Andrade, J. D., Olsen, D. B.: Trans. Amer. Soc. Artif. Int. Organs 20, 449 (1974)Google Scholar
  140. 140.
    Jorgensen, K. A., Stoffersen, E.: Thromb. Res. 17, 13 (1980)Google Scholar
  141. 141.
    Novikova, S. P., Dobrova, N. B., Popov, S. A., Selezneva, N.: Patent SSSR No 1097339A, Bull. Izobret. No 22 (1984)Google Scholar
  142. 142.
    Hennink, W. E., Feijen, J., Ebert, C. D., Kim, S. W.: Thromb. Res. 29, 1 (1983)Google Scholar
  143. 143.
    Hennink, W. E., Ebert, C. D., Kim, S. W., Breemhaar, W., Bantjes, A., Feijen, J.: Biomaterials 5, 264 (1984)Google Scholar
  144. 144.
    Lovelock, J. E., Porterfield, J. S.: Nature (London) 167, 39 (1951)Google Scholar
  145. 145.
    Fougnot, C., Jozefowicz, M., Samama, M., Bara, L.: Ann. Biomed. Eng. 7, 441 (1979)Google Scholar
  146. 146.
    Fougnot, C., Jozefowicz, M., Rosenberg, R. D.: Biomaterials 5, 94 (1984)Google Scholar
  147. 147.
    Valuev, L. I., Freidzon, Ya. S., Shibaev, V. P., Gumirova, F. Kh., Platé, N. A.: Dokl. Akad. Nauk SSSR 265, 366 (1982) (in Russian)Google Scholar
  148. 148.
    Moorjani, S., Lupien, P.-J., Awad, J.: Clin. Chim. Acta 77, 21 (1977)Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Nicolai A. Platé
    • 1
  • Lev I. Valuev
    • 1
  1. 1.Department of ChemistryMoscow State UniversityMoscowUSSR

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