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Protein adsorption and materials biocompatibility: A tutorial review and suggested hypotheses

  • J. D. Andrade
  • V. Hlady
Conference paper
Part of the Advances in Polymer Science book series (POLYMER, volume 79)

Abstract

A comprehensive review of protein adsorption at solid-liquid interfaces is presented, including a brief review of protein structure and the principles of protein adsorption. Adsorption-based biocompatibility hypotheses and correlations are discussed, including surface charge, interface energetics, passivation, protein-resistant surfaces, and the role of adsorbed immunoglobulins and complement. New methods for the study of protein adsorption are discussed, including total internal reflection techniques (absorbance, fluorescence, and Raman) and ellipsometry. Qualitative “rules of thumb” of protein adsorption are also presented.

Keywords

Surface Enhance Raman Scattering Protein Adsorption Total Internal Reflection Scatchard Plot Material Biocompatibility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • J. D. Andrade
    • 1
  • V. Hlady
    • 1
  1. 1.College of EngineeringUniversity of UtahSalt Lake CityU.S.A.

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