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Soluble synthetic polymers in biological systems

  • Jaroslav Drobník
  • František Rypáček
Conference paper
Part of the Advances in Polymer Science book series (POLYMER, volume 57)

Abstract

This review summarizes facts and theories on the fate of a soluble polymer in an animal or human body, mainly from the point of view of therapeutic or diagnostic applications in medicine. Analytical methods which are the main source of our knowledge on this subject are discussed. A compartmental model is suggested and the importance of the individual compartmental barriers and the peculiarity of the polymer pharmacokinetics is documented: the molecular weight distribution changes with time in the circulating fraction; the various routes of parenteral administration are not equivalent. The main route of clearance from the body is the glomerular filtration, which is limited by the size and modified by the charge of the molecule. Polymers which pass through glomerulus may be reabsorbed in the tubulus by pinocytosis, which is largely dependent on the chemical nature of the polymer. Synthetic polymers may elicit antibody production, induce immunological tolerance, activate supressor cells, serve as a non-specific immunostimulator, particularity of the macrophage cytotoxicity, etc. Practical applications in medicine require more detailed knowledge of the fate of polymers in the body. Diagnostics is more a promising field for the immediate future.

Keywords

Synthetic Polymer Central Compartment Maleic Anhydride Glomerular Capillary Secondary Lysosome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

DIVEMA

regular 1:2 copolymer of maleic anhydride and divinyl ether

DNP

2,4-dinitrophenol

GPC

gel permeation chromatography

HES

hydroxyethylstarch

MTX

methothrexate

PEG

polyoxirane (poly(ethylene glycol))

PHEA

poly-α,β[N-(2-hydroxyethyl)-D,L-aspartamide]

PHPMA

poly[N-(2-hydroxypropyl)methacrylamide]

PVA

poly(vinyl alcohol)

PVP

polyvinylpyrrolidone

PVPNO

poly(vinylpyridine N-oxide)

RES

reticuloendothelial system

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Jaroslav Drobník
    • 1
  • František Rypáček
    • 1
  1. 1.Institute of Macromolecular ChemistryCzechoslovak Academy of SciencesPrague 6Czechoslovakia

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