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Ionizing radiation and gas plasma (or glow) discharge treatments for preparation of novel polymeric biomaterials

  • Allan S. Hoffman
Conference paper
Part of the Advances in Polymer Science book series (POLYMER, volume 57)

Abstract

There is a wide variety of materials which are foreign to the body and which are used in contact with body fluids. These materials are called biomaterials.

By far, the most diverse use of biomaterials exists within the polymer class: in these organic materials, ionizing radiation and plasma discharges have a unique ability to initiate free radical and ionic reactions without the need to add catalysts or to heat.

There are three basic processes which are utilized for preparing new or modified polymeric biomaterials. They are: (1) surface modification via radiation graft copolymerization or plasma gas discharge; (2) radiation polymerization of pure monomer(s) in solution, or an emulsion, or in the solid state (e.g., below TG); and (3) radiation crosslinking, in a solution or swollen state, or in the solid state.

Simultaneous or subsequent chemical or biochemical-processing steps can yield novel biomaterials having specific biological activity. Immobilization of enzymes, antibodies, drugs, cells, etc. on or within the radiation-processed material can yield novel biomaterial systems with great potential in the clinic or clinical laboratory. These processes and products are reviewed in this chapter.

Keywords

Glow Discharge Plasma Discharge Graft Copolymerization Polymer Surface Polymer Substrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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6 References

Cited in Text

  1. 1.
    Hoffman, A. S.: Synthetic polymer biomaterials — a review, in: IUPAC — Macromolecules (ed.) H. Benoit and P. Rempp, p. 321, London, Pergamon Press 1982Google Scholar
  2. 2.
    Hoffman, A. S.: J. Appl. Polym. Sci., Appl. Polym. Symp. 31, 313 (1977)Google Scholar
  3. 3.
    Hoffman, A. S.: J. Biomed. Matls. Res. Symp. 5(1), 77 (1974)Google Scholar
  4. 4.
    Hoffman, A. S.: Rad. Phys. Chem. 9, 207 (1977)Google Scholar
  5. 5.
    Machi, S., Ishigaki, T.: Genshiryoku Kogyo 24(5), 45 (1978)Google Scholar
  6. 6. a)
    a) Hoffman, A. S.: Rad. Chem. (Japan) 16(31), 12 (1981)Google Scholar
  7. 6. b)
    b) Hoffman, A. S.: Rad. Phys. Chem. 18(1), 323 (1981)Google Scholar
  8. 7.
    Hoffman, A. S. et al.: Rad. Phys. Chem. Vol. 22, Nos. 1/2, pp. 267–283, 1983Google Scholar
  9. 8.
    Hollahan, J. R., Bell, A. T.: Techniques and Applications of Plasma Chemistry, New York, Wiley-Interscience 1974Google Scholar
  10. 9.
    Shen, M., Bell, A. T. (eds.): Plasma Polymerization, ACS Symposium Series 108, Washington, D.C., American Chemical Society 1979Google Scholar
  11. 10.
    Yasuda, H., Gaziki, M.: Biomaterials 2, 68 (1982)Google Scholar
  12. 11.
    Hoffman, A. S.: Surface modifications of polymers for biomedical applications, in: Science and Technology of Polymer Processing (eds.) N. P. Suh and N. H. Sung, p. 200, Cambridge, Mass., MIT Press 1979Google Scholar
  13. 12.
    Hoffman, A. S.: Atomic Energy Rev. 9, 2,347 (1971)Google Scholar
  14. 13.
    Wichterle, O., Lim, D.: Nature 185, 117 (1960)Google Scholar
  15. 14.
    Barvic, M., Kliment, K., Zavadil, M.: J. Biomed. Matls. Res. 1, 313 (1967)Google Scholar
  16. 15.
    Sprincl, L., Kopecek, J., Lim, D.: J. Biomed. Matls. Res. 4, 447 (1971)Google Scholar
  17. 16.
    Abrahams, R. A., Ronel, S. H.: ACS Polym. Preprints 16, 535 (1975)Google Scholar
  18. 17.
    Hoffman, A. S., Ratner, B. D.: ACS Polym. Preprints 16(2), 272 (1975)Google Scholar
  19. 18.
    Hoffman, A. S.: Hydrogels — a broad class of biomaterials, in: Polymers in Medicine and Surgery (eds.) R. L. Kronenthal, Z. Oser and E. Martin, New Jersey, Plenum Press 1975Google Scholar
  20. 19.
    Ratner, B. D., Hoffman, A. S.: Synthetic hydrogels for biomedical applications, in: Hydrogels for Medical and Related Applications, ACS Symposium Series 31 (ed.) J. D. Andrade, p. 1, Washington, D.C., American Chemical Society 1976Google Scholar
  21. 20.
    Ratner, B. D., Hoffman, A. S.: Surface grafted polymers for biomedical applications, in: Synthetic Biomedical Polymers: Concepts and Applications (eds.) W. J. Robinson and M. Szcher, p. 133, Westport, Connecticut, Technomic Publishing Co. 1980Google Scholar
  22. 21.
    Hollahan, J. R., Stafford, B. B., Falb, R. D.: J. Appl. Polym. Sci. 13, 807 (1969)Google Scholar
  23. 22.
    Yasuda, M., Bumgarner, M. O., Mason, L. G.: Improvement of blood compatibility of membranes by discharge polymerization, in: Permeability of Plastic Films and Coatings to Gases, Vapors and Liquids, Polymer Science and Technology, Volume 6 (ed.) H. P. Hopfenberg, p. 453, New York, Plenum Press 1974Google Scholar
  24. 23.
    Chawla, A. S.: Art. Org. 3(1), 92 (1979)Google Scholar
  25. 24.
    Hahn, A. W. et al.: NBS Spec. Publ. 415, 13 (1975)Google Scholar
  26. 25.
    Nichols, M. F. et al.: J. Biomed. Matls. Res. 13, 299 (1979)Google Scholar
  27. 26.
    Yasuda, H. et al.: J. Biomed. Matls. Res. 9, 629 (1975)Google Scholar
  28. 27.
    Chang, F. Y., M. Shen, Bell, A. T.: J. Appl. Polym. Sci. 17, 2915 (1973)Google Scholar
  29. 28.
    Hatada, K., Kobayashi, H., Asai, M.: Org. Coat. and Appl. Polym. Sci. Proc. 47, 391 (1982)Google Scholar
  30. 29.
    Colter, K. D., Bell, A. T., Shen, M.: Biomatls., Med. Dev., Art. Org. 5(1), 1 (1977)Google Scholar
  31. 30.
    Colter, K. D., Bell, A. T., Shen, M.: Biomatls., Med. Dev., Art. Org. 5(1), 13 (1977)Google Scholar
  32. 31.
    Yen, S. P. S. et al.: ACS Polym. Preprints 16(1), 181 (1975)Google Scholar
  33. 32.
    Rembaum, A. et al.: Macromolecules 9, 328 (1976)Google Scholar
  34. 33.
    Rembaum, A., Yen, S. P. S., Volksen, W.: Chem. Tech. 8(3), 182 (1978)Google Scholar
  35. 34.
    Rembaum, A.: ACS Polym. Preprints 20, 354 (1979)Google Scholar
  36. 35.
    Rembaum, A., Yen, S. P. S., Molday, R. S.: J. Macromol. Sci.-Chem. A13, 603 (1979)Google Scholar

Additional References on Radiation-Grafted Hydrogels for Biomedical Applications

  1. 36.
    Yasuda, H., Refojo, M. F.: J. Polym. Sci. A2, 5093 (1964)Google Scholar
  2. 37.
    Laizier, J., Wajs, G.: Resines silicones hydrophiles obtenues par greffage radiochimique, in: Large Radiation Sources for Industrial Process, p. 205, Vienna, IAEA 1969Google Scholar
  3. 38.
    Hoffman, A. S., Kraft, W. G.: ACS Polym. Preprints 13(2), 723 (1972)Google Scholar
  4. 39.
    Hoffman, A. S., Harris, C.: ACS Polym. Preprints 13(2), 740 (1972)Google Scholar
  5. 40.
    Lee, H. B., Shim, H. S., Andrade, J. D.: ACS Polym. Preprints 13, 729 (1972)Google Scholar
  6. 41.
    Ratner, B. D., Hoffman, A. S.: ACS Org. Coat. Plast. Chem. Preprints 33, 286 (1973)Google Scholar
  7. 42.
    Kearney, J. J., Amara, J. J., McDevitt, M. B.: ACS Polymer. Preprints 14, 346 (1973)Google Scholar
  8. 43.
    Ratner, B. D., Hoffman, A. S.: J. Appl. Polym. Sci. 18, 3183 (1974)Google Scholar
  9. 44.
    Hoffman, A. S. et al.: Preparation and application of radiation-grafted hydrogels as biomaterials, in: The Permeability of Plastic Films and Coatings to Gases, Vapors and Liquids (ed.) H. P. Hopfenberg, p. 441, New York, Plenum Press 1975; also ACS Org. Coat. Plast. Chem. Abstracts 34(1), 568 (1974)Google Scholar
  10. 45.
    Meaburn, G. M. et al.: Radiation-induced grafting of hydrogels on silicone rubber surfaces, in: Abstracts of Papers, Fifth International Congress on Radiation Research, p. 200, Seattle, Wash. 1974Google Scholar
  11. 46.
    Ratner, B. D., Hoffman, A. S.: ACS Org. Coat. Plast. Chem. Preprints 33(2), 386 (1973); also Polymer Sci. Tech. Series No. 7, 159 (1975)Google Scholar
  12. 47.
    Ronel, S. H., Abrahams, R. A.: Soc. Plastics Eng. Tech. Papers 21, 570 (1975)Google Scholar
  13. 48.
    Sasaki, T., Ratner, B. D., Hoffman, A. S.: ACS Polym. Preprints 16(2), 435 (1975); also ACS Symposium Series No. 31, 283 (1976)Google Scholar
  14. 49.
    Ratner, B. D., Balisky, T., Hoffman, A. S.: J. Bioeng. 1, 115 (1977)Google Scholar
  15. 50.
    Greer, R. T., Vale, B. H., Knoll, R. L.: Scanning Electron Microscopy 1, 633 (1978)Google Scholar
  16. 51.
    Hoffman, A. S., Ratner, B. D.: ACS Polym. Preprints 20, 423 (1979)Google Scholar
  17. 52.
    Hoffman, A. S., Ratner, B. D.: Rad. Phys. Chem. 14, 831 (1979)Google Scholar
  18. 53.
    Chapiro, A. et al.: Rad. Phys. Chem. 15, 423 (1980)Google Scholar
  19. 54.
    Chapiro, A. et al.: preprint, courtesy of the authorsGoogle Scholar
  20. 55.
    Peppas, N. A., Gehr, T. W. B.: Trans. Amer. Soc. Artif. Int. Organs 24, 404 (1978)Google Scholar
  21. 56.
    Peppas, N. A., Gehr, T. W. B.: J. Appl. Polym. Sci. 24, 2159 (1979)Google Scholar
  22. 57.
    Kamel, I. L.: Rad. Phys. Chem. 9, 711 (1977)Google Scholar
  23. 58.
    Khaw, B., Ratner, B. D., Hoffman, A. S.: ACS Polym. Preprints 16(2), 446 (1975); also ACS Symposium Series No. 31, 295 (1976)Google Scholar
  24. 59.
    Ratner, B. D. et al.: J. Polym. Sci. 66, 363 (1979)Google Scholar
  25. 60.
    Ratner, B. D., Hoffman, A. S., Whiffen, J. D.: Biomatls. Med. Dev. and Artif. Orgs. 3(1), 115 (1975)Google Scholar
  26. 61.
    Ratner, B. D., Hoffman, A. S., Whiffen, J. D.: J. Bioeng. 2, 313 (1978)Google Scholar
  27. 62.
    Hanson, S. R. et al.: Ann. Biomed. Eng. 7, 357 (1979)Google Scholar
  28. 63.
    Hanson, S. R. et al.: Evaluation of artificial surfaces using a baboon arteriovenous shunt model, in Proc. of 1st World Biomaterials Congress, Baden, Austria; London, John Wiley and Sons 1980Google Scholar
  29. 64.
    Hanson, S. R. et al.: Clin. Med. 95, 289 (1980)Google Scholar
  30. 65.
    Hoffman, A. S., Horbett, T. A., Ratner, B. D.: Ann. N.Y. Acad. Sci. 283, 372 (1977)Google Scholar
  31. 66.
    Thon, M. S., Andrade, J. D.: J. Biomed. Matls. Res. 7, 509 (1973)Google Scholar
  32. 67.
    Hoffman, A. S. et al.: Estimation of surface energy components and their potential relevance to biological interactions, in Proceedings of NSF Workshop on Interfacial Phenomena (ed.) J. C. Berg, p. 445, Seattle, Washington, University of Washington 1979Google Scholar
  33. 68.
    Ko, Y. C., Ratner, B. D., Hoffman, A. S.: J. Coll. Interfac. Sci. 82, 25 (1981)Google Scholar
  34. 69.
    Ratner, B. D.: J. Biomed. Matls, Res. 14, 665 (1980)Google Scholar
  35. 70.
    Ratner, B. D., Hoffman, A. S.: Surface characterization of hydrophilic-hydrophobic copolymer model systems. I. A preliminary study, in Adhesion and Adsorption of Polymers, Part B (ed.) L. H. Lee, p. 691, New York, Plenum Press 1980Google Scholar
  36. 71.
    Ratner, B. D. et al.: J. Appl. Polym. Sci. 22, 643 (1977)Google Scholar
  37. 72.
    Ratner, B. D., Hoffman, A. S.: ACS Org. Coat. Plast. Chem. Preprints 40, 714 (1979)Google Scholar
  38. 73.
    Weathersby, P. K. et al.: J. Bioeng. 1(4), 381 (1977)Google Scholar
  39. 74.
    Miller, M. L. et al.: J. Appl. Polym. Sci. 14, 257 (1970)Google Scholar
  40. 75.
    Ziegler, T. F., Miller, M. L.: J. Biomed. Matls. Res. 4, 259 (1970)Google Scholar
  41. 76.
    Lundell, E. O. et al.: ACS Polym. Preprints 16, 541 (1975)Google Scholar
  42. 77.
    Horbett, T. A., Hoffman, A. S.: ACS Advances in Chemistry Series No. 145, Applied Chemistry at Protein Interfaces, p. 230 (1975)Google Scholar
  43. 78.
    Horbett, T. A., Weathersby, P. K., Hoffman, A. S.: Thrombosis Research 12, 319 (1978)Google Scholar
  44. 79.
    Horbett, T. A.: The kinetics of adsorption of plasma proteins to a series of hydrophilic-hydrophobic copolymers, in: Adhesion and Adsorption of Polymers, Part B (ed.) L. H. Lee, p. 677, New York, Plenum Publishing Corp. 1980Google Scholar
  45. 80.
    Horbett, T. A.: Surface enrichment of plasma proteins, in: Proceedings of 1st World Biomaterials Congress (Baden, Austria), London, John Wiley and Sons 1980Google Scholar
  46. 81.
    Weathersby, P. K., Horbett, T. A., Hoffman, A. S.: Trans. Amer. Soc. Artif. Int. Organs 22, 242 (1976)Google Scholar
  47. 82.
    Weathersby, P. K., Horbett, T. A., Hoffman, A. S.: J. Bioeng. 1(4), 395 (1977)Google Scholar
  48. 83.
    Harker, L. A., Hanson, S. R., Hoffman, A. S.: Ann. N.Y. Acad. Sci. 283, 317 (1977)Google Scholar
  49. 84.
    Ratner, B. D. et al.: J. Biomed. Matls. Res. 9, 407 (1975)Google Scholar
  50. 85.
    Sprincl, L., Vacik, J., Kopecek, J.: J. Biomed. Matls. Res. 7, 123 (1973)Google Scholar
  51. 86.
    Gilding, D. K. et al.: Trans. Amer. Soc. Artif. Int. Organs 24, 411 (1978)Google Scholar
  52. 87.
    Kronik, P. L., Rembaum, A.: ACS Polym. Preprints 16, 157 (1975)Google Scholar
  53. 88.
    Muzykewicz, K. J. et al.: J. Biomed. Matls. Res. 9, 487 (1975)Google Scholar
  54. 89.
    Ihlenfeld, J. V. et al.: Trans. Amer. Soc. Artif. Int. Organs 24, 627 (1978)Google Scholar
  55. 90.
    Hasegawa, T. et al.: Surgery 74, 696 (1973)Google Scholar
  56. 91.
    Hoffman, A. S. et al.: Thrombotic events on grafted polyacrylamide-Silastic surfaces as studied in a baboon, in: Morphology and Interactions of Biomaterials (eds.) S. L. Cooper, A. S. Hoffman, N. A. Peppas and B. D. Ratner, p. 59, ACS Advances in Chemistry Series No. 199, York, PA, American Chemical Society 1982Google Scholar
  57. 92.
    Hoffman, A. S. et al.: Artif. Organs 5(Suppl), 540 (1981)Google Scholar
  58. 93.
    Fischer, J. P. et al.: J. Polym. Sci., Polym. Symp No. 66, 443 (1979)Google Scholar
  59. 94.
    Fischer, J. P. et al.: Proc. of 1st World Biomaterials Congress (Baden, Austria), London, John Wiley and Sons 1980Google Scholar
  60. 95.
    Jansen, B., Ellinghorst, G.: J. Polym. Sci., Polym. Symp. No. 66, 465 (1979)Google Scholar
  61. 96.
    Rösinger, S., Fischer, J. P., Fuhge, P.: “Development of Materials with Blood Compatibility by Radiation Processing,” in IAEA Conference Proceedings, Genoble, September 28–October 2 1981, p. 323, Vienna, IAEA 1981Google Scholar
  62. 97.
    Gaussens, G.: Les nouveaux biomateriaux obtenus par l'action des rayonnements ionisants, in: 343, Vienna, IAEA 1981Google Scholar

Additional References on Radiation Crosslinked Polymers for Biomedical Applications

  1. 98.
    Bray, J. C., Merrill, E. W.: J. Biomed. Matls. Res. 7, 433 (1973)Google Scholar
  2. 99.
    Bray, J. C., Merrill, E. W.: J. Appl. Polym. Sci. 17, 3779 (1973)Google Scholar
  3. 100.
    Peppas, N. A., Merrill, E. W.: J. Biomed. Matls. Res. 11, 423 (1977)Google Scholar
  4. 101.
    Ikada, Y., Mita, T.: Rad. Phys. Chem. 9, 633 (1977)Google Scholar
  5. 102.
    Kalal, J., Bednar, B., Houska, M.: ACS Polym. Preprints 16, 363 (1975)Google Scholar
  6. 103.
    Vlasova, N. K. et al.: Stomatologiya (Moscow) 50, 33 (1971)Google Scholar
  7. 104.
    Weathersby, P. K., Kolobow, T., Stool, E. W.: J. Biomed. Matls. Res. 9, 561 (1975)Google Scholar
  8. 105.
    Chawla, A. S.: J. Bioeng. 2, 231 (1978)Google Scholar
  9. 106.
    Gifford, G. H., Jr., Merrill, E. W., Morgan, M. S.: J. Biomed. Matls. Res. 10, 857 (1976)Google Scholar
  10. 107.
    du Plessis, T. A., Grobbelaar, C. J., Marais, F.: Rad. Phys. Chem. 9, 647 (1977)Google Scholar
  11. 108.
    Grobbelaar, C. J., du Plessis, T. A., Marais, F.: J. Bone Joint Surg. (London) 60B, 370 (1978)Google Scholar
  12. 109.
    Shimizu, Y. et al.: Biomatls. Med. Dev. Artif. Organs 6, 375 (1978)Google Scholar
  13. 110.
    Al-Saden, A. A. et al.: Internatl. J. Pharmaceutics 5, 317 (1980)Google Scholar
  14. 111.
    Gaussens, G., Nicaise, M., Tran, K. O.: Protheses articulaires a base de polymeres ameliorés sous rayonnements ionisants, in: IAEA Conference Proceedings, Grenoble, September 28–October 2 1981, p. 373, Vienna, IAEA 1981Google Scholar

Additional References on Radiation-Processed Biomaterials Cäntaining Immobilized Biomolecules

  1. 112.
    Dobo, J.: Acta Chim. Acad. Sci. Hung. 63, 453 (1970)Google Scholar
  2. 113.
    Maeda, H., Yamauchi, A., Suzuki, H.: Biochim. Biophys. Acta 315, 18 (1973)Google Scholar
  3. 114.
    Maeda, H., Suzuki, H., Yamauchi, A.: Biotech. Bioeng. 15, 827 (1973)Google Scholar
  4. 115.
    Maeda, H. et al.: Biotech. Bioeng. 17, 119 (1975)Google Scholar
  5. 116.
    Maeda, H., Suzuki, H.: Proc. Biochem. 12(6), 9 (1977)Google Scholar
  6. 117.
    Kawashima, K., Umeda, K.: Biotech. Bioeng. 16, 609 (1974)Google Scholar
  7. 118.
    Kawashima, K., Umeda, K.: Agric. Biol. Chem. 40(6), 1143 (1976)Google Scholar
  8. 119.
    Kawashima, K., Umeda, K.: Agric. Biol. Chem. 40(6), 1151 (1976)Google Scholar
  9. 120.
    Kumakura, M. et al.: J. Solid Phase Biochem. 2, 279 (1977)Google Scholar
  10. 121.
    Kaetsu, I., Kumakura, M., Yoshida, M.: Biotech. Bioeng. 21, 847 (1979)Google Scholar
  11. 122.
    Kaetsu, I., Kumakura, M., Yoshida, M.: Biotech. Bioeng. 21, 863 (1979)Google Scholar
  12. 123.
    Kaetsu, I. et al.: Rad. Phys. Chem. 14, 595 (1979)Google Scholar
  13. 124.
    Kaetsu, I. et al.: J. Biomed. Matls. Res. 14, 199 (1980)Google Scholar
  14. 125.
    Yoshida, M., Kumakura, M., Kaetsu, I.: Polymer 20, 3 (1979)Google Scholar
  15. 126.
    Yoshida, M., Kumakura, M., Kaetsu, I.: Polymer 20, 9 (1979)Google Scholar
  16. 127.
    Yoshida, M., Kumakura, M., Kaetsu, I.: Polymer J. 11, 915 (1979)Google Scholar
  17. 128.
    Kumakura, M., Yoshida, M., Kaetsu, I.: Appl. Env. Microbiol. 37, 310 (1979)Google Scholar
  18. 129.
    Kumakura, M., Yoshida, M., Kaetsu, I.: Biotech. Bioeng. 21, 679 (1979)Google Scholar
  19. 130.
    Yoshida, M., Kumakura, M., Kaetsu, I.: Polymer 19, 1375 (1978)Google Scholar
  20. 131.
    Yoshida, M., Kumakura, M., Kaetsu, I.: Polymer 19, 1379 (1978)Google Scholar
  21. 132.
    Yoshida, M., Kumakura, M., Kaetsu, I.: J. Pharmaceut. Sci. 68, 628 (1979)Google Scholar
  22. 133.
    Yoshida, M., Kumakura, M., Kaetsu, I.: Polymer J. 11, 775 (1979)Google Scholar
  23. 134.
    Yoshida, M., Kumakura, M., Kaetsu, I.: J. Pharmaceut. Sci. 68, 860 (1979)Google Scholar
  24. 135.
    Kaetsu, I., Yoshida, M., Yamada, A.: J. Biomed. Matls. Res. 14, 185 (1980)Google Scholar
  25. 136.
    Kaetsu, I. et al.: Biomaterials 1, 17 (1980)Google Scholar
  26. 137.
    Leininger, R. I. et al.: Trans. Amer. Soc. Artif. Int. Organs 12, 155 (1966)Google Scholar
  27. 138.
    Leininger, R. I. et al.: Science 152, 1625 (1966)Google Scholar
  28. 139.
    Falb, R. D. et al.: J. Biomed. Matals. Res. 1, 239 (1967)Google Scholar
  29. 140.
    Leininger, R. I., Falb, R. D., Grode, G. A.: Ann. N.Y. Acad. Sci. 146, 11 (1968)Google Scholar
  30. 141.
    Rembaum, A., Singer, S., Keyzer, H.: Polym. Letters 7, 395 (1969); also NASA Tech. Brief, No. 69-10299, August 1969Google Scholar
  31. 142.
    Chawla, A. S., Chang, T. M. S.: ACS Polym. Preprints 14, 379 (1973); also Biomatls. Med. Dev. Artif. Orgs. 2, 157 (1972)Google Scholar
  32. 143.
    Hoffman, A. S. et al.: Trans. Amer. Soc. Artif. Int, Orgs. 18, 10 (1972)Google Scholar
  33. 144.
    Hoffman, A. S., Schmer, G.: New approaches to non-thrombogenic materials, in: Current Topics in Coagulation (ed.) G. Schmer, p. 201, New York, Academic Press 1973Google Scholar
  34. 145.
    Hoffman, A. S., Schmer, G.: Paroi Arterielle — Arterial Wall 1, 95 (1973)Google Scholar
  35. 146.
    Mate, T. P. et al.: pH effects in the covalent coupling of small molecules and proteins to poly (HEMA-methacrylic acid) hydrogels, in: Enzyme Engineering (eds.) Pye and Wingard, p. 137, New York, Plenum Press 1975Google Scholar
  36. 147.
    Smiley, K. L., Boundy, J. A.: Presented at American Chemical Society Meeting, Chicago, 1973Google Scholar
  37. 148.
    Venkataraman, S., Horbett, T. A., Hoffman, A. S.: ACS Polym. Preprints 16(2), 197 (1975); also J. Biomed. Matls. Res. 11, 111 (1977)Google Scholar
  38. 149.
    Venkataraman, S., Horbett, T. A., Hoffman, A. S.: J. Mol. Catalysis 2, 273 (1977)Google Scholar
  39. 150.
    Barker, H. et al.: A radiation grafting technique for the immobilization of enzymes and the heterogenizing of catalytically active homogeneous metal complexes, in: Proceedings of the VIth Internatl. Congr. Catalysis, p. 551, London, The Chemical Society 1977Google Scholar
  40. 151.
    Liddy, M. J., Garnett, J. L., Kenyon, R. S.: J. Polym. Sci., Symp. No. 49, 109 (1975)Google Scholar
  41. 152.
    Molday, R. S. et al.: Nature 249, 81 (1974)Google Scholar
  42. 153.
    Molday, R. S. et al.: J. Cell. Biol. 64, 75 (1975)Google Scholar
  43. 154.
    Gordon, I. L. et al.: Cell Immunol. 28, 307 (1977)Google Scholar
  44. 155.
    Catt, K., Niall, H. D., Tregear, G. W.: Biochem. J. 100, 31c (1966)Google Scholar
  45. 156.
    Catt, K., Niall, H. D., Tregear, G. W.: J. Lab. Clin. Med. 70, 820 (1967)Google Scholar
  46. 157.
    Catt, K., Niall, H. D., Tregear, G. W.: J. Exp. Biol. Med. Sci. 45, 703 (1967)Google Scholar
  47. 158.
    Catt, K., Niall, H. D., Tregear, G. W.: J. Clin. Endocrin. Metabolism 28, 121 (1968)Google Scholar
  48. 159.
    Tregear, G. W.: in Solid Phase Proteins — Their Preparation, Properties and Applications (ed.) A. S. Hoffman, Proceedings of a Conference at Battelle-Seattle Research Center, September 1971Google Scholar
  49. 160.
    Kobayashi, M., Kaetsu, I.: Physical immobilization of biofunctional substance by the use of radiation polymerization, In: IAEA Conference Proceedings, Grenoble, September 28–October 2, 1981, p. 353, Vienna, IAEA 1981Google Scholar

Additional References on Gas Discharge Polymer Treatments for Biomedical Applications

  1. 161.
    Scott, H., Hillman, E. E.: Active-vapor grafting of hydrogels in medical prostheses, Contract No. NIH-HHL1-71-2017, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, Annual Report (February 1, 1973), PB-221-846Google Scholar
  2. 162.
    Smith, L. et al.: ACS Polym. Preprints 16(2), 186 (1975)Google Scholar
  3. 163.
    Yasuda, H. et al.: J. Biomed. Matls. Res. 9, 629 (1975)Google Scholar
  4. 164.
    Yasuda, H., Bumgarner, M. O., Mason, R. G.: Biomatls., Med. Dev., Artif. Int. Orgs. 4, 307 (1976)Google Scholar
  5. 165.
    Chawla, A. S.: Trans. Amer. Soc. Artif. Int. Orgs. 25, 287 (1979)Google Scholar
  6. 166.
    Nichols, M. F. et al.: J. Biomed. Matls. Res. 13, 299 (1979)Google Scholar
  7. 167.
    Hahn, A. W. et al.: Biomed. Scient. Instrumentation 15, 7 (1979)Google Scholar
  8. 168.
    Yasuda, H.: A study of electrodeless glow discharge as a means of modifying the surface of polymers Annual Reports No. NIH-NO1-HV-3-2913-1 through NIH-NO1-HV-3-2913-7 (1972–1979)Google Scholar
  9. 169.
    Cannon, J. G. et al.: J. Biomed. Matls. Res. 14, 279 (1980)Google Scholar
  10. 170.
    Özdural, A. R. et al.: Am. Soc. Artif. Int. Organs J. 3, 116 (1980)Google Scholar
  11. 171.
    Hahn, A. W. et al.: Biomed. Sci. Instrumentation 17, 109 (1981)Google Scholar
  12. 172.
    Nichols, M. F. et al.: Biomaterials 2, 161 (1981)Google Scholar
  13. 173.
    Sadhir, R. K. et al.: Biomaterials 2, 239 (1981)Google Scholar
  14. 174.
    Yasuda, H.: J. Polymer Sci., Macromol. Rev. 16, 199 (1981)Google Scholar
  15. 175.
    Hahn, A. W. et al.: Org. Coat. and Appl. Polym. Sci. Proc. 47, 386 (1982)Google Scholar
  16. 176.
    Matsuzawa, Y., Yasuda, H.: Org. Coat. and Appl. Polym. Sci. Proc. 47, 397 (1982)Google Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Allan S. Hoffman
    • 1
  1. 1.Center for Bioengineering and Department of Chemical EngineeringUniversity of WashingtonSeattleUSA

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