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Soluble synthetic polymers as potential drug carriers

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Polymers in Medicine

Part of the book series: Advances in Polymer Science ((POLYMER,volume 57))

Abstract

Soluble synthetic polymers provide a potential targetable drug delivery system. In this article we discuss the consequences of the attachment of pharmaceuticals to macromolecular carriers with special reference to endocytosis and lysosomotropic drug delivery. The types of polymers which may be used as carriers are reviewed with particular regard to the methodology currently available in polymer chemistry for the synthesis of polymers bearing cell-specific targeting residues and incorporating effective polymer drug linkages. In order to be successful in drug delivery, the polymeric drug carrier must behave in a predictable and favourable manner in the biological environment. Studies concerned with the biological properties of synthetic polymers are also reviewed. The idea of using drug carriers to improve the therapeutic efficacy of pharmacological agents is receiving increasing attention, and the relationship between soluble synthetic polymers and other proposed carriers is discussed together with possible clinical applications.

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Abbreviations

DIVEMA:

Divinyl ether and maleic anhydride copolymer

DMSO:

Dimethyl sulfoxide

DOPA:

3,4-Dihydroxyphenylalanine

DSC:

Differential scanning calorimetry

HMDA:

Hexamethylenediamine

IME:

2-Imino-2-methoxyethyl-1-thioglycoside

MTX:

Methotrexate

NAp:

p-Nitroaniline

PAH:

Poly(acryl hydrazide)

PDM:

p-Phenylenediamine mustard

PEG:

Poly(ethylene glycol)

PEO:

Poly(ethylene oxide)

PGA:

Poly(glutamic acid)

poly(Lys):

Polylysine

poly(vA):

Polyvinyladenine

poly(vU):

Polyvinyluracil

PVP:

Polyvinylpyrrolidone

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Authors and Affiliations

  1. Biochemistry Research Laboratory, Department of Biological Sciences, University of Keele, ST5 5BG, Keele, Staffordshire, U.K.

    Ruth Duncan

  2. Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, 16206, Prague 6, Czechoslovakia

    Jindřich Kopeček

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  1. Ruth Duncan
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  2. Jindřich Kopeček
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© 1984 Springer-Verlag

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Duncan, R., Kopeček, J. (1984). Soluble synthetic polymers as potential drug carriers. In: Polymers in Medicine. Advances in Polymer Science, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-12796-8_10

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  • DOI: https://doi.org/10.1007/3-540-12796-8_10

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-12796-3

  • Online ISBN: 978-3-540-38740-4

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