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The chemistry of technetium: Toward improved diagnostic agents

  • Michael J. Clarke
  • Paul H. Fackler
Conference paper
Part of the Structure and Bonding book series (STRUCTURE, volume 50)

Abstract

Within the last five years significant advances have been made in elucidating the chemistry of technetium. While this element is continually produced in some abundance during the operation of fission nuclear reactors, its practical application has been limited to nuclear medicine. Owing to the development of the “technetium generator” almost two decades ago, 99mTc is now the preferred isotope for many diagnostic studies involving the imaging of internal organs by radioscintigraphic techniques; however, many of the agents employed have yet to be well characterized from a chemical standpoint. Owing to its position in the middle of the periodic table, the chemistry of this element has already proven rich, even when limited to aqueous solution. Subtle chemical differences often control the relative stabilities of the various oxidation states and each oxidation state exhibits more than one geometry. Coordination complexes involving Tc(III), Tc(IV) and Tc(V) tend to predominate in preparations used for diagnosis. Recent synthetic advances now pave the way for new series of technetium compounds with well-described chemistry. Of these, methods for coordinating chelating nitrogen ligands to Tc(V) offer substantial versatility. (This review covers the literature through August, 1981.)

Keywords

Bond Distance Nitrogen Ligand Dithiolate Ligand Hydrohalic Acid Technetium Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

acac

2,4-pentanedione

nBu

n-butyl

cat

1,2-dihydroxybenzene

cyclam

1,4,8,11-tetraazacyclotetradecane

diars

o-phenylenebis(dimethylarsine)

diphos

bis(diphenylphosphine) ethane

DMF

N,N-dimethylformamide

DMG

dimethylglyoxime

DTPA

diethylenetriaminepentaacetate

EDTA

ethylenediaminetetraacetate

ema

N,N′-ethylenebis (2-mercaptoacetimide)

en

ethylenediamine Et ethyl

HEDP

(1-hydroxyethylidene)diphosphate

HIDA

N-(2,6 dimethylphenylcarbamoylmethyl)iminodiacetate

HTFMS

trifluoromethanesulfonic acid

IDA

iminodiacetate

Im

imidazole

MDP

methylenediphosphonate

Me

methyl

NADH

educed nicotinamide adenine dinucleotide

NHE

normal hydrogen electrode

Ph

phenyl

Pyr

pyridine

SCE

standard calomel electrode

TBAP

tetrabutylammonium perchlorate

tdt

3,4-dimercaptotoluene

TEAP

tetraethylammonium perchlorate

TMAP

tetramethylammonium perchlorate

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Michael J. Clarke
    • 1
  • Paul H. Fackler
    • 1
  1. 1.Department of ChemistryBoston CollegeChestnut HillUSA

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