Advertisement

Metabolism of alkanes by yeasts

  • S. Fukui
  • A. Tanaka
Conference paper
Part of the Advances in Biochemical Engineering book series (ABE, volume 19)

Abstract

One of the specific features of alkane-utilizing yeasts is the conspicuous appearance of peroxisomes. This review describes the metabolism of alkanes in yeasts with special emphasis on the physiological function of peroxisomes. The subtle diversity in alkane utilization pathway in yeasts is mediated by subcellular localization of enzymes.

In microsomes, alkanes are hydroxylated to the corresponding fatty alcohols which are further oxidized to fatty acids via aldehydes in microsomes, mitochondria and peroxisomes, respectively. Degradation of fatty acids to acetyl-CoA via the β-oxidation pathways is carried out exclusively in peroxisomes while fatty acids formed in microsomes and mitochondria are incorporated into cellular lipids, each after being activated to acyl-CoAs. Acetyl-CoA produced in peroxisomes is converted to C4-compounds by the cooperative action of peroxisomes and mitochondria. Some regulation of enzymes in alkane-assimilating yeasts is also discussed.

Keywords

Cellular Fatty Acid Glyoxylate Cycle Isocitrate Lyase Exogenous Fatty Acid Carnitine Acetyltransferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

12 References

  1. 1.
    Abbott, B. J., Gledhill, W. E.: Adv. Appl. Microbiol. 14, 249 (1971)CrossRefGoogle Scholar
  2. 2.
    Fukui, S., Tanaka, A.: Advan. Biochem. Eng. 17, 1 (1980)Google Scholar
  3. 3.
    Iguchi, T., Takeda, I., Ohsawa, H.: Agric. Biol. Chem. 33, 1657 (1969)Google Scholar
  4. 4.
    Meissel, M. N. et al.: Proc. Third Internatl. Spec. Symp. Yeasts (Otaniemi/Helsinki), p. 149 (1973)Google Scholar
  5. 5.
    Meissel, M. N., Medvedeva, G. A., Kozlova, T. M.: Mikrobiologiya 45, 844 (1976)Google Scholar
  6. 6.
    Osumi, M. et al.: J. Ferment. Technol. 53, 244 (1975)Google Scholar
  7. 7.
    Einsele, A., Schneider, H., Fiechter, A.: J. Ferment. Technol. 53, 241 (1975)Google Scholar
  8. 8.
    Kaeppeli, O., Fiechter, A.: Biotechnol. Bioeng. 18, 967 (1976)CrossRefGoogle Scholar
  9. 9.
    Käppeli, O., Fiechter, A.: J. Bacteriol. 131, 917 (1977)Google Scholar
  10. 10.
    Käppeli, O., Müller, M., Fiechter, A.: J. Bacteriol. 133, 952 (1978)Google Scholar
  11. 11.
    Peterson, J. A. et al.: J. Biol. Chem. 242, 4334 (1967)Google Scholar
  12. 12.
    Cardini, G., Jurtshuk, P.: J. Biol. Chem. 245, 2789 (1970)Google Scholar
  13. 13.
    Liu, C.-M, Johnson, M. J.: J. Bacteriol. 106, 830 (1971)Google Scholar
  14. 14.
    Lebeault, J. M., Lode, E. T., Coon, M. J.: Biochem. Biophys. Res. Commun. 42, 413 (1971)CrossRefGoogle Scholar
  15. 15.
    Gallo, M., Bertrand, J. C, Azoulay, E.: FEBS Lett. 19, 45 (1971)CrossRefGoogle Scholar
  16. 16.
    Müller, H. G. et al.: Acta Biol. Med. Germ. 38, 345 (1979)Google Scholar
  17. 17.
    Gallo, M. et al.: Biochim. Biophys. Acta 296, 624 (1973)Google Scholar
  18. 18.
    Gallo, M. et al.: Biochimie 55, 195 (1973)Google Scholar
  19. 19.
    Gallo, M., Roche, B., Azoulay, E.: Biochim. Biophys. Acta 419, 425 (1976)CrossRefGoogle Scholar
  20. 20.
    Gilewicz, M. et al.: Can. J. Microbiol. 25, 201 (1979)CrossRefGoogle Scholar
  21. 21.
    Bertrand, J. C. et al.: FEBS Lett. 105, 143 (1979)CrossRefGoogle Scholar
  22. 22.
    Bertrand, J. C. et al.: Eur. J. Biochem. 93, 237 (1979)CrossRefGoogle Scholar
  23. 23.
    Duppel, W., Lebeault, J. M., Coon, M. J.: Eur. J. Biochem. 36, 583 (1973)CrossRefGoogle Scholar
  24. 24.
    Strobel, H. W., Coon, M. J.: J. Biol. Chem. 246, 7826 (1971)Google Scholar
  25. 25.
    Iida, M., Iizuka, H.: J. Ferment. Technol. 47, 442 (1969)Google Scholar
  26. 26.
    Finnerty, W. R.: Trends in Biochem. Sci. 2, 73 (1977)CrossRefGoogle Scholar
  27. 27.
    Lebeault, J. M. et al.: Biochim. Biophys. Acta 220, 373 (1970)Google Scholar
  28. 28.
    Lebeault, J. M. et al.: Biochim. Biophys. Acta 220, 386 (1970)Google Scholar
  29. 29.
    Lebeault, J. M., Azoulay, E.: Lipids 6, 444 (1971)Google Scholar
  30. 30.
    Gallo, M., Roche-Penverne, B., Azoulay, E.: FEBS Lett. 46, 78 (1974)CrossRefGoogle Scholar
  31. 31.
    Yamada, T. et al.: Arch. Microbiol. 128, 145 (1980)CrossRefGoogle Scholar
  32. 32.
    Osumi, M. et al.: Arch. Microbiol. 99, 181 (1974)CrossRefGoogle Scholar
  33. 33.
    Teranishi, Y. et al.: Agric. Biol. Chem. 38, 1213 (1974)Google Scholar
  34. 34.
    Teranishi, Y. et al.: Agric. Biol. Chem. 38, 1221 (1974)Google Scholar
  35. 35.
    Osumi, M. et al.: Arch. Microbiol. 103, 1 (1975)CrossRefGoogle Scholar
  36. 36.
    Kawamoto, S. et al.: Arch. Microbiol. 112, 1 (1977)CrossRefGoogle Scholar
  37. 37.
    Osumi, M. et al.: J. Gen. Appl. Microbiol. 21, 375 (1975)Google Scholar
  38. 38.
    Mishina, M. et al.: Eur. J. Biochem. 89, 321 (1978)CrossRefGoogle Scholar
  39. 39.
    Osumi, M.: J. Electron Microsc. 25, 43 (1976)Google Scholar
  40. 40.
    Osumi, M., Kazama, H., Sato, S.: FEBS Lett. 90, 309 (1978)CrossRefGoogle Scholar
  41. 41.
    Fukui, S., Tanaka, A.: J. Appl. Biochem. 1, 171 (1979)Google Scholar
  42. 42.
    Fukui, S., Tanaka, A.: Trends in Biochem. Sci. 4, 246 (1979)CrossRefGoogle Scholar
  43. 43.
    Trust, T. J., Millis, N. F.: J. Bacteriol. 104, 1397 (1970)Google Scholar
  44. 44.
    Duvnjak, Z. et al.: Biochim. Biophys. Acta 202, 447 (1970)Google Scholar
  45. 45.
    Kawamoto, S., Nozaki, C, Tanaka, A., Fukui, S.: Eur. J. Biochem. 83, 609 (1978)CrossRefGoogle Scholar
  46. 46.
    Kamiryo, T. et al.: Proc. Nat. Acad. Sci. USA 74, 4947 (1977)CrossRefGoogle Scholar
  47. 47.
    Mishina, M. et al.: Eur. J. Biochem. 82, 347 (1978)CrossRefGoogle Scholar
  48. 48.
    Hosaka, K. et al.: Eur. J. Biochem. 93, 197 (1979)CrossRefGoogle Scholar
  49. 49.
    Cooper, T. G., Beevers, H.: J. Biol. Chem. 244, 3514 (1969)Google Scholar
  50. 50.
    Lazarow, P. B., de Duve, C: Proc. Nat. Acad. Sci. USA 73, 2043 (1976)CrossRefGoogle Scholar
  51. 51.
    Kikuchi, T. et al.: Abstr. Res. Meeting Lipid Biochem., p. 144, Toyama, Japan 1979Google Scholar
  52. 52.
    Shimizu, S. et al.: Biochem. Biophys. Res. Commun. 91, 108 (1979)CrossRefGoogle Scholar
  53. 53.
    Kawamoto, S. et al.: FEBS Lett. 97, 253 (1979)CrossRefGoogle Scholar
  54. 54.
    Mishina, M. et al.: Agric. Biol. Chem. 37, 863 (1973)Google Scholar
  55. 55.
    Rattray, J. M. B., Schibeci, A., Kidby, D. K.: Bacteriol. Rev. 39, 197 (1975)Google Scholar
  56. 56.
    Nomura, S. et al.: J. Antibiotics 25, 365 (1972)Google Scholar
  57. 57.
    Vance, D. et al.: Biochem. Biophys. Res. Commun. 48, 649 (1972)CrossRefGoogle Scholar
  58. 58.
    Tanaka, A. et al.: Eurp. J. Appl. Microbiol. 3, 115 (1976)CrossRefGoogle Scholar
  59. 59.
    Mishina, M. et al.: Eur. J. Biochem. 71, 301 (1976)CrossRefGoogle Scholar
  60. 60.
    Gill, C. O. Ratledge, C.: J. Gen. Microbiol. 78, 337 (1973)Google Scholar
  61. 61.
    Mishina, M. et al.: Eur. J. Biochem. 71, 295 (1976)CrossRefGoogle Scholar
  62. 62.
    Tanaka, A. et al.: Europ. J. Appl. Microbiol. Biotechnol. 5, 79 (1978)CrossRefGoogle Scholar
  63. 63.
    Hildebrandt, W., Weide, H.: Z. Allg. Mikrobiol. 14, 47 (1974)Google Scholar
  64. 64.
    Nabeshima, S., Tanaka, A., Fukui, S.: Agric. Biol. Chem. 41, 275 (1977)Google Scholar
  65. 65.
    Hirai, M. et al.: Agric. Biol. Chem. 40, 1819 (1976)Google Scholar
  66. 66.
    Tanaka, A. et al.: Agric. Biol. Chem. 41, 795 (1977)Google Scholar
  67. 67.
    Hirai, M. et al: Agric. Biol. Chem. 40, 1979 (1976)Google Scholar
  68. 68.
    Kawamoto, S. et al.: FEBS Lett. 96, 37 (1978)CrossRefGoogle Scholar
  69. 69.
    Tabuchi, T., Serizawa, N.: Agric. Biol. Chem. 39, 1055 (1975)Google Scholar
  70. 70.
    Tabuchi, T., Uchiyama, H.: Agric. Biol. Chem. 39, 2035 (1975)Google Scholar
  71. 71.
    Uchiyama, H., Tabuchi, T.: Agric. Biol. Chem. 40, 1411 (1976)Google Scholar
  72. 72.
    Tabuchi, T., Satoh, T.: Agric. Biol. Chem. 40, 1863 (1976)Google Scholar
  73. 73.
    Tabuchi, T., Satoh, T.: Agric. Biol. Chem. 41, 169 (1977)Google Scholar
  74. 74.
    Tabuchi, T., Igoshi, K.: Agric. Biol. Chem. 42, 2381 (1978)Google Scholar
  75. 75.
    Hatton, K., Suzuki, T.: Agric. Biol. Chem. 38, 2419 (1974)Google Scholar
  76. 76.
    Hattori, K., Suzuki, T.: Agric. Biol. Chem. 39, 57 (1975)Google Scholar
  77. 77.
    Akiyama, S. et al.: Agric. Biol. Chem. 37, 885 (1973)Google Scholar
  78. 78.
    Sato, S., Nakahara, T., Minoda, Y.: Agric. Biol. Chem. 41, 1903 (1977)Google Scholar
  79. 79.
    Teranishi, Y. et al.: Agric. Biol. Chem. 38, 1581 (1974)Google Scholar
  80. 80.
    Teranishi, Y., Tanaka, A., Fukui, S.: Agric. Biol. Chem. 38, 1779 (1974)Google Scholar
  81. 81.
    Yamamura, M. et al.: Agric. Biol. Chem. 39, 13 (1975)Google Scholar
  82. 82.
    Akimenko, V. K., Medentsev, A. G., Golovchenko, N. P.: FEBS Lett. 45, 22 (1974)CrossRefGoogle Scholar
  83. 83.
    Gallo, M., Azoulay, E.: Biochimie 56, 1129 (1974)Google Scholar
  84. 84.
    Mitsushima, K., Shinmyo, A., Enatsu, T.: J. Ferment. Technol. 54, 863 (1976)Google Scholar
  85. 85.
    Mitsushima, K., Shinmyo, A., Enatsu, T.: J. Ferment. Technol. 55, 84 (1977)Google Scholar
  86. 86.
    Mitsushima, K., Shinmyo, A., Enatsu, T.: Biochim. Biophys. Acta 538, 481 (1978)Google Scholar
  87. 87.
    Hirai, M. et al.: Biochim. Biophys. Acta 480, 357 (1977)Google Scholar
  88. 88.
    Hirai, M., Tanaka, A., Fukui, S.: Biochim. Biophys. Acta 391, 282 (1975)Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • S. Fukui
    • 1
  • A. Tanaka
    • 1
  1. 1.Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of EngineeringKyoto UniversityKyotoJapan

Personalised recommendations