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Microbial reactions in prostaglandin chemistry

Conference paper
Part of the Advances in Biochemical Engineering book series (ABE, volume 17)

Abstract

Microbial reactions are used in the preparation of prostaglandins and prostaglandin derivatives. Although the applications of microbial reactions in prostaglandin chemistry is in its earlier stages, many microbial reactions have already been elucidated. Prostaglandins and prostaglandin-like substances have been prepared microbiologic-ally from carbon and nitrogen sources. Microbial reactions have been used as an integral part of total synthetic schemes. Particularly, microbial reactions have been used to prepare optically active intermediates or products. Various prostaglandin derivatives have been prepared by microbial transformation for structure-activity correlations.

The various microbial reactions elucidated are: microbial reductions of ketones and double bonds, microbial hydroxylations, microbial oxidations and microbial hydrolysis of esters. The feasibility of microbial reactions in prostaglandin chemistry has been documented. The potential demands for microbial reactions in prostaglandin chemistry is enhanced as the demands for optically pure prostaglandins increases.

Keywords

Total Synthesis Microbial Transformation Microbial Reduction Cyclopentane Ring Microbial Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • J. Jiu
    • 1
  1. 1.G. D. Searle and CompanyResearch and Development DivisionChicagoU.S.A.

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