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Treatment of the folding and unfolding of protein molecules in solution according to a lattice model

  • J. HermansJr.
  • D. Lohr
  • D. Ferro
Conference paper
Part of the Advances in Polymer Science book series (POLYMER, volume 9)

Keywords

Equilibrium Constant Protein Molecule Transition Curve Elementary Step Conformation Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Symbols

K

Equilibrium constant for folding

K'

Equilibrium constant for unfolding

Kunf

Same as K'

k0i

Rate constant for folding a site with i folded neighbors

k1i

Rate constant for unfolding a site with i folded neighbors

ki

Rate constant for forming species i + 1 from species i

Ki

Equilibrium constant for forming species i from species 0

ks

Steady state rate constant

kxo

Exchange rate constant for free peptide hydrogens

li

Rate constant for forming species i from species i + 1

M

Number of contacts in a completely folded lattice

N

Total number of sites in the lattice

p

Equilibrium constant for folding a site

P

Number of ways of realizing a given conformation

q

Equilibrium constant for forming a contact between two folded sites

s

Equilibrium constant for helix growth

t

temperature in °C; time

T

Temperature in °K

w

Equilibrium constant for forming a specified conformation

z

Partition function

θ

Degree of folding

θ′

Degree of unfolding

θ′i

Degree of unfolding for site (type) i

μ

Number of contacts between folded sites

ν

Number of sites which are folded

σ

Equilibrium constant for helix initiation

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • J. HermansJr.
    • 1
  • D. Lohr
    • 1
  • D. Ferro
    • 1
  1. 1.Department of BiochemistryUniversity of North CarolinaChapel HillUSA

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