EGJ Dysfunction and GERD

  • P. J. Kahrilas
  • J. E. Pandolfino


Theories of the mechanism of gastroesophageal junction competence have seesawed between strictly anatomic explanations, focusing on type-I hiatus hernia, and physiologic explanations focusing on the vigor of LES contraction while ignoring the significance of anatomic factors. As detailed above, current thinking recognizes contributions from both sphincteric components. Furthermore, there is an increasing understanding of mechanical elements of the antireflux barrier, inclusive of, but nor restricted to hiatus hernia and the intrinsic LES. Thus, our view of GERD pathogenesis as it pertains to EGJ competence is now focusing on quantifying the mechanical properties of this complex anatomical zone. Future research will likely focus on methods to measure EGJ compliance and elasticity, as these are the mechanical parameters that influence gastroesophageal reflux.


Hiatus Hernia Lower Esophageal Sphincter Gastric Cardia GERD Patient Esophageal Acid Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag/Wien 2006

Authors and Affiliations

  • P. J. Kahrilas
    • 1
  • J. E. Pandolfino
    • 1
  1. 1.Department of MedicineNorthwestern University’s Feinberg School of Medical SchoolChicagoUSA

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