Schlussfolgerungen
Wichtig für ein besseres Verständnis des Injektionsvorganges bei der Vertebroplastik waren vor allem die Analyse der Bedeutung des Injektionsdruckes und der Zementviskosität für den Ausgang der Behandlung.
Die Betrachtung des theoretischen Modells des Injektionsdruckes lieferte ein erstaunliches Ergebnis. Ca. 95% des gesamten Injektionsdruckes wird dafür benötigt, die Reibung zwischen der Kanülenwand und dem Zement zu überwinden (extravertebraler Druck), und nur 5% des gesamten Injektionsdruckes ist notwendig für die Ausbreitung des Zementes in der Spongiosa (intravertebraler Druck). Die nachfolgenden Experimente haben bestätigt, dass der intravertebrale Druck deutlich geringer ist, als der extravertebrale Druck.
Die Analyse des Extravasationsrisikos ergab, dass vor allem durch die Verwendung eines höher viskösen Zementes dieses Risiko deutlich gesenkt werden kann. Außerdem würde ein niedrigerer Injektionsdruck und damit ein niedrigerer intravertebraler Druck die gleichmäßige Ausbreitung des Zementes begünstigen.
Zur Verbesserung des Injektionsprozesses haben wir eine neue Kanüle entwickelt. Diese trägt auf Grund ihrer Geometrie deutlich zur Senkung des Injektionsdruckes bei. Dadurch können höher visköse Zemente besser eingespritzt werden und das Risiko einer unzureichenden Füllung des Wirbelkörpers mit Zement wird gesenkt. Bis die neue Kanüle jedoch endgültig im klinischen Betrieb eingesetzt werden kann, sind weitere Tests erforderlich.
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Literatur
Baroud G, Bohner M, Heini P, Steffen T (2001a) Injection biomechanics of bone cements used in vertebroplasty. Biomed Mater Eng 14(4): 487–504
Baroud G, Falk R, Crookshank M, Sponagel S, Steffen T (2001b) Experimental and theoretical investigation of the directional permeability of cancellous bone for cement infiltration. J Biomech 37(2): 189–96
Baroud G, Martin P-L, Cabana F: Ex-vivo experiments of a new injection instrument for vertebroplasty. Spine J (in Druck)
Baroud G, Vant C, Giannitsios D, Bohner M, Steffen T (2005a) Effect of vertebral shell on injection pressure and intravertebral pressure in vertebroplasty. Spine 30(1): 68–74
Baroud G, Wu JZ, Bohner M, Sponagel S, Steffen T (2003) How to determine the permeability for cement infiltration into osteoporotic cancellous bone. Med Eng Phys 25(4): 283–8
Baroud G, Steffen T (2005b) A new cannula to ease cement injection during vertebroplasty. Eur Spine J 14(5): 474–9
Bohner M, Gasser B, Baroud G, Heini P (2003) Theoretical and experimental model to describe the injection of a polymethylmethacrylate cement into a porous structure. Biomaterials 24(16): 2721–30
Cotten A, Dewatre F, Cortet B, Assaker R, Leblond D, Duquesnoy B, Chastanet P, Clarisse J (1996) Percutaneous vertebroplasty for osteolytic metastases and myeloma: effect of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up. Radiology 200(2): 525–30
Deramond H, Depriester C, Galibert P, Le Gars D (1998) Percutaneous vertebroplasty with polymethylmethacrylate. Radiol Clin North Am 36(3): 533–46
Heini PF, Berlemann U, Kaufmann M, Lippuner K, Fankhauser C, van Landuyt P (2001) Augmentation of mechanical properties in osteoporotic vertebral bones — a biomechanical investigation of vertebroplasty efficacy with different bone cements. Eur Spine J 10(2): 164–71
Heini PF, Walchli B, Berlemann U (2000) Percutaneous transpedicular vertebroplasty with PMMA: operative technique and early results. A prospective study for the treatment of osteoporotic compression fractures. Eur Spine J 9(5): 445–50
Jensen AJ, Evans JM, Mathis (1997) Percutaneous polymethylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral body compression fractures: technical aspects. Am J Neuroradiol 18(10): 1897–904
Krause WR, Miller J, Ng P (1982) The viscosity of acrylic bone cements. J Biomed Mater Res 16(3): 219–43
Mathis JM, Barr JD, Belkoff SM, Barr MS, Jensen ME, Deramond H (2001) Percutaneous vertebroplasty: a developing standard of care for vertebral compression fractures. AJNR Am J Neuroradiol 22(2): 373–81
Naumann EA, Fong KE, Keaveny TM (1999) Dependence of intertrabecular permeability on flow direction and anatomic site. Ann Biomed En 27(4): 517–24
San Millan Ruiz D, Burkhardt K, Jean B, Muster M, Martin JB, Bouvier J, Fasel JH, Rufenacht DA, Kurt AM (1999) Pathology findings with acrylic implants. Bone 25[2 Suppl]: 85–90
Wilson DR, Myers ER, Mathis JM, Scribner RM, Conta JA, Reiley MA, Talmadge KD, Hayes WC (2000) Effect of augmentation on the mechanics of the vertebral wedge fractures. Spine 25(2): 158–65
Literatur
Ananthakrishnan D, Lotz JC, Berven S, Puttlitz C (2003) Changes in spinal loading due to vertebral augmentation: vertebroplasty versus kyphoplasty. Annual Meeting of the American Academy of Orthopaedic Surgeons, New Orleans, p 472
Baroud G, Goerke U, Beckman L, Steffen T (2001a) Physical changes of the vertebral tissue treated with vertebroplasty. XVIIIth Congress of International Society of Biomechanics, Zurich, p 728
Baroud G, Steffen T (2001b) Poster Session: Load shift after augmenting osteoporotic vertebrae. J Biomech 34[1 Suppl]: 57
Baroud G, Nemes J, Ferguson S, Steffen T (2003) Material changes in osteoporotic human cancellous bone following infiltration with acrylic bone cement for a vertebral cement augmentation. Computer Methods in Biomechanics & Biomedical Engineering 6(2): 133–9
Baroud G, Nemes J, Heini P, Steffen T (2003) Load shift of the intervertebral disc after a vertebroplasty: a finiteelement study. Eur Spine J 12(4): 421–6
Belkoff SM, Mathis JM, Erbe EM, Fenton DC (2000) Biomechanical evaluation of a new bone cement for use in vertebroplasty. Spine 25(9): 1061–4
Belkoff SM, Mathis JM, Jasper LE, Deramond H (2001) The biomechanics of vertebroplasty. The effect of cement volume on mechanical behaviour. Spine 26(14): 1537–41
Belkoff SM, Mathis JM, Jasper LE (2002) Ex vivo biomechanical comparison of hydroxyapatite and polymethylmethacrylate cements for use with vertebroplasty. AJNR Am J Neuroradiol 23(10): 1647–51
Berlemann U, Ferguson SJ, Nolte LP, Heini PF (2002) Adjacent vertebral failure after vertebroplasty. A biomechanical investigation. J Bone Joint Surg Br 84(5): 748–52
Brinckmann P, Frobin W, Hierholzer E, Horst M (1983) Deformation of the vertebral end-plate under axial loading of the spine. Spine 8(8): 851–6
De Wijn JR (1976) Poly(methyl methacrylate)-aqueous phase blends: in situ curing porous materials. J Biomed Mater Res 10(4): 625–35
Dean JR, Ison KT, Gishen P (2000) The strengthening effect of percutaneous vertebroplasty. Clin Radiol 55(6): 471–6
Ferguson SJ, Berlemann U, Polikeit A, Heini PF, Nolte LP (2001) Are adjacent vertebrae at risk following vertebroplasty? J Biomech 34[1 Suppl]: 10
Fribourg D, Tang C, Sra P, Delamarter R, Bae H (2004) Incidence of subsequent vertebral fracture after kyphoplasty. Spine 29(20): 2270–76
Grados F, Depriester C, Cayrolle G, Hardy N, Deramond H, Fardellone P (2000) Long-term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty. Rheumatology (Oxford) 39(12): 1410–4
Heini PF, Berlemann U, Kaufmann M, Lippuner K, Fankhauser C, van Landuyt P (2001) Augmentation of mechanical properties in osteoporotic vertebral bones — a biomechanical investigation of vertebroplasty efficacy with different bone cement. Eur Spine J 10(2): 164–71
Heini PF, Orler R (2004) Vertebroplastik bei hochgradiger Osteoporose Technik und Erfahrung mit plurisegmentalen Injektionen. Orhopade 33(1): 22–30
Kim SH, Kang HS, Choi J-A, Ahn JM (2004) Risk factors of new compression fractures in adjacent vertebrae after percutaneous vertebroplasty. Acta Radiologica 45(4): 440–5(6)
Legroux-Gerot I, Lormeau C, Boutry N, Cotten A, Duquesnoy B, Cortet B (2004) Long-term follow-up of vertebral osteoporotic fractures treated by percutaneous vertebroplasty. Clin Rheumatol 23(4): 310–7
Liebschner MA, Rosenberg WS, Keaveny TM (2001) Effects of bone cement volume and distribution on vertebral stiffness after vertebroplasty. Spine 26(14): 1547–54
Lindsay R, Silverman SL, Cooper C, Hanley DA, Barton I, Broy SB, Licata A, Benhamou L, Geusens P, et al (2001) Risk of new vertebral fracture in the year following a fracture. Jama 285(3): 320–3
Lu WW, Cheung KM, Li YW, Luk KD, Holmes AD, Zhu QA, Leong JC (2001) Bioactive bone cement as a principal fixture for spinal burst fracture: an in vitro biomechanical and morphologic study. Spine 26(2): 2684–90; discussion 2690-1
Polikeit A, Nolte LP, Ferguson SJ (2001) The effect of vertebroplasty on the load transfer in a functional spinal unit. J Biomech 34[1 Suppl]: 10–11
Polikeit A, Nolte LP, Ferguson SJ (2003) The effect of cement augmentation on the load transfer in an osteoporotic functional spinal unit: finite-element analysis. Spine 28(10): 991–6
Rockoff SD, Sweet E, Bleustein J (1969) The relative contribution of trabecular and cortical bone strength to the strength of human lumbar vertebrae. Calcif Tissue Res 3: 163–75
Rohlmann A, Zander T, Jony A, Weber U, Bergmann G (2005) Einfluss der Wirbelkörpersteifigkeit vor und nach der Vertebroplastik auf den intradiskalen Druck. Biomed Technik 50(5): 148–52
Ross PD, Genant HK, Davis JW, Miller PD, Wasnich RD (1993) Predicting vertebral fracture incidence from prevalent fractures and bone density among non-black, osteoporotic women. Osteoporos Int 3(3): 120–6
Sun K, Liebschner AK (2004) Evolution of vertebroplasty: a biomechanical perspective. Annals of Biomed Eng 32(1): 77–91
Uppin AA, Hirsch JA, Centenera LV, Pfiefer BA, Pazianos AG, Choi IS (2003) Occurrence of new vertebral body fracture after percutaneous vertebroplasty in patients with osteoporosis. Radiology 226(1): 119–24
Watts NB, Harris, ST, Genant HK (2001) Treatment of painful osteoporotic vertebral fractures with percutaneous vertebroplasty or kyphoplasty. Osteoporos Int 12(6): 429–37
Wilcox RK (2004) Do vertebroplasty cements have the optimum mechanical properties? Transactions of 7th World Biomaterials Congress, Sydney, Abstract 1547
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Baroud, G., Schmidt, F., Baroud, G. (2006). Biomechanik. In: Becker, S., Ogon, M. (eds) Ballonkyphoplastie. Springer, Vienna. https://doi.org/10.1007/3-211-32315-5_4
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