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Tic disorders and obsessive compulsive disorder: where is the link?

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Neurodevelopmental Disorders

Summary

Over the last years evidence on the overlap between tic-disorders (TD) and obsessive compulsive behavior/disorder (OCB/OCD) has increased. The main focus of research have been the phenomenological and epidemiological similarities and differences in samples of different age, primary diagnosis (TD vs. OCD) including the co-occurrence of both. Unfortunately, only a minority of studies included all three groups (TD, TD+OCD, OCD). Nevertheless, new insight concerning possible subtypes for both TD and OCD has been gained. While some authors concentrated on OCD with/without tics we will summarize the field of TD and OCB/OCD from the viewpoint of tics, since OCB plays an important role in patients with TD. Thereby we will not only sharpen the clinicans’ awareness of known differences in phenomenology, epidemiology, genetics and neurobiology, aimed to improve their diagnoses and treatment but also highlight the gaps of knowledge and discuss possibilities for further research in this field.

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References

  • Alsobrook JP 2nd, Pauls DL (2002) A factor analysis of tic symptoms in Gilles de la Tourette’s syndrome. Am J Psychiatry 159: 291–296

    Article  PubMed  Google Scholar 

  • American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders. American Psychiatric Association, Washington

    Google Scholar 

  • Apter A, Pauls DL, Bleich A, Zohar AH, Kron S, Ratzoni G, Dycian A, Kotler M, Weizman A, Gadot N, et al. (1993) An epidemiologic study of Gilles de la Tourette’s syndrome in Israel. Arch Gen Psychiatry 50: 734–738

    PubMed  CAS  Google Scholar 

  • Azrin NH, Nunn RG (1973) Habit-reversal: a method of eliminating nervous habits and tics. Behav Res Ther 11: 619–628

    Article  PubMed  CAS  Google Scholar 

  • Baer L (1994) Factor analysis of symptom subtypes of obsessive compulsive disorder and their relation to personality and tic disorders. J Clin Psychiatry 55[Suppl]: 18–23

    PubMed  Google Scholar 

  • Banaschewski T, Siniatchkin M, Uebel H, Rothenberger A (2003a) [Compulsive phenomena in children with tic disorder and attention deficit-hyperactive disorder]. Z Kinder Jugendpsychiatr Psychother 31: 203–211

    Article  PubMed  CAS  Google Scholar 

  • Banaschewski T, Woerner W, Rothenberger A (2003b) Premonitory sensory phenomena and suppressibility of tics in Tourette syndrome: developmental aspects in children and adolescents. Dev Med Child Neurol 45: 700–703

    Article  PubMed  Google Scholar 

  • Barr CL, Wigg KG, Sandor P (1999) Catechol-O-methyltransferase and Gilles de la Tourette syndrome. Mol Psychiatry 4: 492–495

    Article  PubMed  CAS  Google Scholar 

  • Barr CL, Wigg KG, Zovko E, Sandor P, Tsui LC (1996) No evidence for a major gene effect of the dopamine D4 receptor gene in the susceptibility to Gilles de la Tourette syndrome in five Canadian families. Am J Med Genet 67: 301–305

    Article  PubMed  CAS  Google Scholar 

  • Barr CL, Wigg KG, Zovko E, Sandor P, Tsui LC (1997) Linkage study of the dopamine D5 receptor gene and Gilles de la Tourette syndrome. Am J Med Genet 74: 58–61

    Article  PubMed  CAS  Google Scholar 

  • Berardelli A, Curra A, Fabbrini G, Gilio F, Manfredi M (2003) Pathophysiology of tics and Tourette syndrome. J Neurol 250: 781–787

    Article  PubMed  Google Scholar 

  • Bhattacharyya S, Reddy YCJ, Khanna S, Prasanna CLN (2004) Is the genetic pool of OCD and tic disorder absent in India? In: Abstracts XIIth World Congress of Psychiatric Genetics. Am J Med Genet Part B: Neuropsychiatr Genet 130B: 68

    Google Scholar 

  • Billett EA, Richter MA, Sam F, Swinson RP, Dai XY, King N, Badri F, Sasaki T, Buchanan JA, Kennedy JL (1998) Investigation of dopamine system genes in obsessive-compulsive disorder. Psychiatr Genet 8: 163–169

    PubMed  CAS  Google Scholar 

  • Bliss J (1980) Sensory experiences of Gilles de la Tourette syndrome. Arch Gen Psychiatry 37: 1343–1347

    PubMed  CAS  Google Scholar 

  • Brett PM, Curtis D, Robertson MM, Gurling HM (1995) The genetic susceptibility to Gilles de la Tourette syndrome in a large multiple affected British kindred: linkage analysis excludes a role for the genes coding for dopamine D1, D2, D3, D4, D5 receptors, dopamine beta hydroxylase, tyrosinase, and tyrosine hydroxylase. Biol Psychiatry 37: 533–540

    Article  PubMed  CAS  Google Scholar 

  • Brett PM, Curtis D, Robertson MM, Gurling HM (1997) Neuroreceptor subunit genes and the genetic susceptibility to Gilles de la Tourette syndrome. Biol Psychiatry 42: 941–947

    Article  PubMed  CAS  Google Scholar 

  • Bruggeman R, van der Linden C, Buitelaar JK, Gericke GS, Hawkridge SM, Temlett JA (2001) Risperidone versus pimozide in Tourette’s disorder: a comparative double-blind parallel-group study. J Clin Psychiatry 62: 50–56

    Article  PubMed  CAS  Google Scholar 

  • Bruun RD (1984) Gilles de la Tourette’s syndrome. An overview of clinical experience. J Am Acad Child Psychiatry 23: 126–133

    PubMed  CAS  Google Scholar 

  • Bruun RD, Budman CL (1992) The natural history of Tourette syndrome. Adv Neurol 58: 1–6

    PubMed  CAS  Google Scholar 

  • Bruun RD, Budman CL (1996) Risperidone as a treatment for Tourette’s syndrome. J Clin Psychiatry 57: 29–31

    PubMed  CAS  Google Scholar 

  • Bruun RD, Budman CL (1997) The course and prognosis of Tourette syndrome. Neurol Clin 15: 291–298

    Article  PubMed  CAS  Google Scholar 

  • Buchanan AW, Meng KS, Marks IM (1996) What predicts improvement and compliance during the behavioral treatment of obsessive compulsive disorder? Anxiety 2: 22–27

    Article  PubMed  CAS  Google Scholar 

  • Budman CL, Bruun RD, Park KS, Lesser M, Olson M (2000) Explosive outbursts in children with Tourette’s disorder. J Am Acad Child Adolesc Psychiatry 39: 1270–1276

    Article  PubMed  CAS  Google Scholar 

  • Budman CL, Bruun RD, Park KS, Olson ME (1998) Rage attacks in children and adolescents with Tourette’s disorder: a pilot study. J Clin Psychiatry 59: 576–580

    PubMed  CAS  Google Scholar 

  • Budman CL, Gayer A, Lesser M, Shi Q, Bruun RD (2001) An open-label study of the treatment efficacy of olanzapine for Tourette’s disorder. J Clin Psychiatry 62: 290–294

    Article  PubMed  CAS  Google Scholar 

  • Bullen JG, Hemsley DR (1983) Sensory experience as a trigger in Gilles de la Tourette’s syndrome. J Behav Ther Exp Psychiatry 14: 197–201

    Article  PubMed  CAS  Google Scholar 

  • Calabrese G, Colombo C, Bonfanti A, Scotti G, Scarone S (1993) Caudate nucleus abnormalities in obsessive-compulsive disorder: measurements of MRI signal intensity. Psychiatry Res 50: 89–92

    Article  PubMed  CAS  Google Scholar 

  • Calamari JE, Wiegartz PS, Riemann BC, Cohen RJ, Greer A, Jacobi DM, Jahn SC, Carmin C (2004) Obsessive-compulsive disorder subtypes: an attempted replication and extension of a symptom-based taxonomy. Behav Res Ther 42: 647–670

    Article  PubMed  Google Scholar 

  • Calvocoressi L, Lewis B, Harris M, Trufan SJ, Goodman WK, McDougle CJ, Price LH (1995) Family accommodation in obsessive-compulsive disorder. Am J Psychiatry 152: 441–443

    PubMed  CAS  Google Scholar 

  • Cardona F, Romano A, Bollea L, Chiarotti F (2004) Psychopathological problems in children affected by tic disorders — study on a large Italian population. Eur Child Adolesc Psychiatry 13: 166–171

    Article  PubMed  Google Scholar 

  • Casey DA, Davis MH (1994) Obsessive-compulsive disorder responsive to electroconvulsive therapy in an elderly woman. South Med J 87: 862–864

    PubMed  CAS  Google Scholar 

  • Castillo JCR, Castillo ARGL, Biason L, Miguita K, Ikenaga E, Vallada HP (2004) Is 5HT1D-beta involved in the pathogenesis of tic-related OCD? Preliminary results from an OCD paediatric sample ascertained through Tourette’s probands. In: Abstracts XIIth World Congress of Psychiatric Genetics. Am J Med Genet Part B: Neuropsychiatr Genet 122B(1): 91

    Google Scholar 

  • Cath DC, Spinhoven P, Hoogduin CA, Landman AD, van Woerkom TC, van de Wetering BJ, Roos RA, Rooijmans HG (2001a) Repetitive behaviors in Tourette’s syndrome and OCD with and without tics: what are the differences? Psychiatry Res 101: 171–185

    Article  PubMed  CAS  Google Scholar 

  • Cath DC, Spinhoven P, Landman AD, van Kempen GM (2001b) Psychopathology and personality characteristics in relation to blood serotonin in Tourette’s syndrome and obsessive-compulsive disorder. J Psychopharmacol 15: 111–119

    Article  PubMed  CAS  Google Scholar 

  • Cath DC, Spinhoven P, van de Wetering BJ, Hoogduin CA, Landman AD, van Woerkom TC, Roos RA, Rooijmans HG (2000) The relationship between types and severity of repetitive behaviors in Gilles de la Tourette’s disorder and obsessive-compulsive disorder. J Clin Psychiatry 61: 505–513

    PubMed  CAS  Google Scholar 

  • Cavallini MC, Di Bella D, Catalano M, Bellodi L (2000) An association study between 5-HTTLPR polymorphism, COMT polymorphism, and Tourette’s syndrome. Psychiatry Res 97: 93–100

    Article  PubMed  CAS  Google Scholar 

  • Chabane N, Millet B, Delorme R, Lichtermann D, Mathieu F, Laplanche JL, Roy I, Mouren MC, Hankard R, Maier W, Launay JM, Leboyer M (2004) Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans. Neurosci Lett 363: 154–156

    Article  PubMed  CAS  Google Scholar 

  • Chae JH, Nahas Z, Wassermann E, Li X, Sethuraman G, Gilbert D, Sallee FR, George MS (2004) A pilot safety study of repetitive transcranial magnetic stimulation (rTMS) in Tourette’s syndrome. Cogn Behav Neurol 17: 109–117

    Article  PubMed  Google Scholar 

  • Chang HL, Tu MJ, Wang HS (2004) Tourette’s syndrome: psychopathology in adolescents. Psychiatr Clin Neurosci 58: 353–358

    Article  Google Scholar 

  • Chee KY, Sachdev P (1994) The clinical features of Tourette’s disorder: an Australian study using a structured interview schedule. Aust NZ J Psychiatry 28: 313–318

    CAS  Google Scholar 

  • Chee KY, Sachdev P (1997) A controlled study of sensory tics in Gilles de la Tourette syndrome and obsessive-compulsive disorder using a structured interview. J Neurol Neurosurg Psychiatry 62: 188–192

    PubMed  CAS  Google Scholar 

  • Church AJ, Dale RC, Giovannoni G (2004) Anti-basal ganglia antibodies: a possible diagnostic utility in idiopathic movement disorders? Arch Dis Child 89: 611–614

    Article  PubMed  CAS  Google Scholar 

  • Coffey BJ, Biederman J, Geller DA, Spencer T, Park KS, Shapiro SJ, Garfield SB (2000) The course of Tourette’s disorder: a literature review. Harv Rev Psychiatry 8: 192–198

    Article  PubMed  CAS  Google Scholar 

  • Cohen AJ, Leckman JF (1992) Sensory phenomena associated with Gilles de la Tourette’s syndrome. J Clin Psychiatry 53: 319–323

    PubMed  CAS  Google Scholar 

  • Comer JS, Kendall PC, Franklin ME, Hudson JL, Pimentel SS (2004) Obsessing/worrying about the overlap between obsessive-compulsive disorder and generalized anxiety disorder in youth. Clin Psychol Rev 24: 663–683

    Article  PubMed  Google Scholar 

  • Comings DE, Comings BG (1985) Tourette syndrome: clinical and psychological aspects of 250 cases. Am J Hum Genet 37: 435–450

    PubMed  CAS  Google Scholar 

  • Comings DE, Comings BG (1987) A controlled study of Tourette syndrome. IV. Obsessions, compulsions, and schizoid behaviors. Am J Hum Genet 41: 782–803

    PubMed  CAS  Google Scholar 

  • Comings DE, Comings BG, Muhleman D, Dietz G, Shahbahrami B, Tast D, Knell E, Kocsis P, Baumgarten R, Kovacs BW, et al. (1991) The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. Jama 266: 1793–1800

    Article  PubMed  CAS  Google Scholar 

  • Comings DE, Himes JA, Comings BG (1990) An epidemiologic study of Tourette’s syndrome in a single school district. J Clin Psychiatry 51: 463–469

    PubMed  CAS  Google Scholar 

  • Comings DE, MacMurray JP (2003) Maternal age at the birth of the first child as an epistatic factor in psychiatric genetics. In: Abstracts XIth World Congress of Psychiatric Genetics. Am J Med Genet Part B: Neuropsychiatr Genet 122B(1): 52

    Google Scholar 

  • Comings DE, Rostamkhani M, Emami R, MacMurray JP (2003) Association between the vesicular monoamine transporter VMAT2 and co-morbid symptoms in Tourette’s syndrome patients. In: Abstracts XIth World Congress of Psychiatric Genetics. Am J Med Genet Part B: Neuropsychiatr Genet 122B(1): 51

    Google Scholar 

  • Costello EJ, Angold A, Burns BJ, Stangl DK, Tweed DL, Erkanli A, Worthman CM (1996) The Great Smoky Mountains Study of Youth. Goals, design, methods, and the prevalence of DSM-III-R disorders. Arch Gen Psychiatry 53: 1129–1136

    PubMed  CAS  Google Scholar 

  • Cruz C, Camarena B, King N, Paez F, Sidenberg D, de la Fuente JR, Nicolini H (1997) Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics. Neurosci Lett 231: 1–4

    Article  PubMed  CAS  Google Scholar 

  • de Groot CM (1997) Course of obsessive-compulsive symptoms in Tourette’s syndrome. Depress Anxiety 6: 165–169

    Article  PubMed  Google Scholar 

  • de Groot CM, Bornstein RA, Janus MD, Mavissakalian MR (1994) Patterns of obsessive compulsive symptoms in Tourette subjects are independent of severity. Anxiety 1: 268–274

    PubMed  Google Scholar 

  • Devor EJ (1984) Complex segregation analysis of Gilles de la Tourette syndrome: further evidence for a major locus mode of transmission. Am J Hum Genet 36: 704–709

    PubMed  CAS  Google Scholar 

  • Devor EJ, Grandy DK, Civelli O, Litt M, Burgess AK, Isenberg KE, van de Wetering BJ, Oostra B (1990) Genetic linkage is excluded for the D2-dopamine receptor lambda HD2G1 and flanking loci on chromosome 11q22–q23 in Tourette syndrome. Hum Hered 40: 105–108

    PubMed  CAS  Google Scholar 

  • Diaz-Anzaldua A, Joober R, Riviere JB, Dion Y, Lesperance P, Richer F, Chouinard S, Rouleau GA (2004) Tourette syndrome and dopaminergic genes: a family-based association study in the French Canadian founder population. Mol Psychiatry 9: 272–277

    Article  PubMed  CAS  Google Scholar 

  • Diniz JB, Rosario-Campos MC, Shavitt RG, Curi M, Hounie AG, Brotto SA, Miguel EC (2004) Impact of age at onset and duration of illness on the expression of comorbidities in obsessive-compulsive disorder. J Clin Psychiatry 65: 22–27

    PubMed  Google Scholar 

  • Dougherty DD, Rauch SL, Jenike MA (2004) Pharmacotherapy for obsessive-compulsive disorder. J Clin Psychol 16: 446–455

    Google Scholar 

  • Drummond LM (1993) The treatment of severe, chronic, resistant obsessive-compulsive disorder. An evaluation of an in-patient programme using behavioural psychotherapy in combination with other treatments. Br J Psychiatry 163: 223–229

    PubMed  CAS  Google Scholar 

  • Eapen V, Moriarty J, Robertson MM (1994) Stimulus induced behaviours in Tourette’s syndrome. J Neurol Neurosurg Psychiatry 57: 853–855

    PubMed  CAS  Google Scholar 

  • Eapen V, Pauls DL, Robertson MM (1993) Evidence for autosomal dominant transmission in Tourette’s syndrome. United Kingdom cohort study. Br J Psychiatry 162: 593–596

    PubMed  CAS  Google Scholar 

  • Eisenhauer GL, Woody RC (1987) Self-mutilation and Tourette’s disorder. J Child Neurol 2: 265–267

    Article  PubMed  CAS  Google Scholar 

  • Evers RA, van de Wetering BJ (1994) A treatment model for motor tics based on a specific tension-reduction technique. J Behav Ther Exp Psychiatry 25: 255–260

    Article  PubMed  CAS  Google Scholar 

  • Evidente VG (2000) Is it a tic or Tourette’s? Clues for differentiating simple from more complex tic disorders. Postgrad Med 108: 175–176, 179–182

    PubMed  CAS  Google Scholar 

  • Farid BT (1986) Irritability and resistance in obsessional neurosis. Psychopathology 19: 289–293

    PubMed  CAS  Google Scholar 

  • Faridi K, Suchowersky O (2003) Gilles de la Tourette’s syndrome. Can J Neurol Sci 30[Suppl 1]: S64–S71

    PubMed  Google Scholar 

  • Frankel M, Cummings JL, Robertson MM, Trimble MR, Hill MA, Benson DF (1986) Obsessions and compulsions in Gilles de la Tourette’s syndrome. Neurology 36: 378–382

    PubMed  CAS  Google Scholar 

  • Franklin ME, Kozak MJ, Cashman LA, Coles ME, Rheingold AA, Foa EB (1998) Cognitive-behavioral treatment of pediatric obsessive-compulsive disorder: an open clinical trial. JAm Acad Child Adolesc Psychiatry 37: 412–419

    Article  CAS  Google Scholar 

  • Freeman RD, Fast DK, Burd L, Kerbeshian J, Robertson MM, Sandor P (2000) An international perspective on Tourette syndrome: selected findings from 3,500 individuals in 22 countries. Dev Med Child Neurol 42: 436–447

    Article  PubMed  CAS  Google Scholar 

  • Gadzicki D, Muller-Vahl KR, Heller D, Ossege S, Nothen MM, Hebebrand J, Stuhrmann M (2004) Tourette syndrome is not caused by mutations in the central cannabinoid receptor (CNR1) gene. Am J Med Genet 127B: 97–103

    Article  PubMed  Google Scholar 

  • Gaffney GR, Perry PJ, Lund BC, Bever-Stille KA, Arndt S, Kuperman S (2002) Risperidone versus clonidine in the treatment of children and adolescents with Tourette’s syndrome. JAm Acad Child Adolesc Psychiatry 41: 330–336

    Article  Google Scholar 

  • Gelernter J, Kennedy JL, Grandy DK, Zhou QY, Civelli O, Pauls DL, Pakstis A, Kurlan R, Sunahara RK, Niznik HB, et al. (1993) Exclusion of close linkage of Tourette’s syndrome to D1 dopamine receptor. Am J Psychiatry 150: 449–453

    PubMed  CAS  Google Scholar 

  • Gelernter J, Pakstis AJ, Pauls DL, Kurlan R, Gancher ST, Civelli O, Grandy D, Kidd KK (1990) Gilles de la Tourette syndrome is not linked to D2-dopamine receptor. Arch Gen Psychiatry 47: 1073–1077

    PubMed  CAS  Google Scholar 

  • Gelernter J, Rao PA, Pauls DL, Hamblin MW, Sibley DR, Kidd KK (1995a) Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome. Genomics 26: 207–209

    Article  PubMed  CAS  Google Scholar 

  • Gelernter J, Vandenbergh D, Kruger SD, Pauls DL, Kurlan R, Pakstis AJ, Kidd KK, Uhl G (1995b) The dopamine transporter protein gene (SLC6A3): primary linkage mapping and linkage studies in Tourette syndrome. Genomics 30: 459–463

    Article  PubMed  CAS  Google Scholar 

  • Geller D, Biederman J, Jones J, Park K, Schwartz S, Shapiro S, Coffey B (1998) Is juvenile obsessive-compulsive disorder a developmental subtype of the disorder? A review of the pediatric literature. J Am Acad Child Adolesc Psychiatry 37: 420–427

    Article  PubMed  CAS  Google Scholar 

  • Geller DA, Biederman J, Stewart SE, Mullin B, Farrell C, Wagner KD, Emslie G, Carpenter D (2003) Impact of comorbidity on treatment response to paroxetine in pediatric obsessive-compulsive disorder: is the use of exclusion criteria empirically supported in randomized clinical trials? J Child Adolesc Psychopharmacol 13(Suppl 1): S19–S29

    Article  PubMed  Google Scholar 

  • George MS, Trimble MR, Ring HA, Sallee FR, Robertson MM (1993) Obsessions in obsessive-compulsive disorder with and without Gilles de la Tourette’s syndrome. Am J Psychiatry 150: 93–97

    PubMed  CAS  Google Scholar 

  • Giakas WJ (1995) Risperidone treatment for a Tourette’s disorder patient with comorbid obsessive-compulsive disorder. Am J Psychiatry 152: 1097–1098

    PubMed  CAS  Google Scholar 

  • Gilles de la Tourette G (1885) Etude sur une affection nerveuse caracterisee par de l’incoordination motrice accompagnee d’echolalie et de copralalie. Arch Neurol: 19–42, 158–200

    Google Scholar 

  • Goetz CG, Kompoliti K (2001) Rating scales and quantitative assessment of tics. In: Cohen DJ, Goetz CG, Jankovic J (eds) Tourette syndrome. Lippincott, Williams & Wilkins, New York, pp 31–42

    Google Scholar 

  • Goetz CG, Tanner CM, Stebbins GT, Leipzig G, Carr WC (1992) Adult tics in Gilles de la Tourette’s syndrome: description and risk factors. Neurology 42: 784–788

    PubMed  CAS  Google Scholar 

  • Grad LR, Pelcovitz D, Olson M, Matthews M, Grad GJ (1987) Obsessive-compulsive symptomatology in children with Tourette’s syndrome. JAm Acad Child Adolesc Psychiatry 26: 69–73

    CAS  Google Scholar 

  • Grados MA, Riddle MA, Samuels JF, Liang KY, Hoehn-Saric R, Bienvenu OJ, Walkup JT, Song D, Nestadt G (2001) The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family study. Biol Psychiatry 50: 559–565

    Article  PubMed  CAS  Google Scholar 

  • Grados MA, Walkup J, Walford S (2003) Genetics of obsessive-compulsive disorders: new findings and challenges. Brain Dev 25(Suppl 1): S55–S61

    Article  PubMed  Google Scholar 

  • Greenberg BD, Ziemann U, Cora-Locatelli G, Harmon A, Murphy DL, Keel JC, Wassermann EM (2000) Altered cortical excitability in obsessive-compulsive disorder. Neurology 54:142–147

    PubMed  CAS  Google Scholar 

  • Grice DE, Leckman JF, Pauls DL, Kurlan R, Kidd KK, Pakstis AJ, Chang FM, Buxbaum JD, Cohen DJ, Gelernter J (1996) Linkage disequilibrium between an allele at the dopamine D4 receptor locus and Tourette syndrome, by the transmission-disequilibrium test. Am J Hum Genet 59: 644–652

    PubMed  CAS  Google Scholar 

  • Guttmacher LB, Cretella H (1988) Electroconvulsive therapy in one child and three adolescents. J Clin Psychiatry 49: 20–23

    PubMed  CAS  Google Scholar 

  • Hanna GL, McCracken JT, Cantwell DP (1991) Prolactin in childhood obsessive-compulsive disorder: clinical correlates and response to clomipramine. J Am Acad Child Adolesc Psychiatry 30: 173–178

    PubMed  CAS  Google Scholar 

  • Hanna PA, Janjua FN, Contant CF, Jankovic J (1999) Bilineal transmission in Tourette syndrome. Neurology 53: 813–818

    PubMed  CAS  Google Scholar 

  • Hasstedt SJ, Leppert M, Filloux F, van de Wetering BJ, McMahon WM (1995) Intermediate inheritance of Tourette syndrome, assuming assortative mating. Am J Hum Genet 57: 682–689

    PubMed  CAS  Google Scholar 

  • Hebebrand J, Klug B, Fimmers R, Seuchter SA, Wettke-Schafer R, Deget F, Camps A, Lisch S, Hebebrand K, von Gontard A, Lehmkuhl G, Poustka F, Schmidt M, Baur MP, Remschmidt H (1997) Rates for tic disorders and obsessive compulsive symptomatology in families of children and adolescents with Gilles de la Tourette syndrome. J Psychiatr Res 31: 519–530

    Article  PubMed  CAS  Google Scholar 

  • Hebebrand J, Nothen MM, Lehmkuhl G, Poustka F, Schmidt M, Propping P, Remschmidt H (1993) Tourette’s syndrome and homozygosity for the dopamine D3 receptor gene. German Tourette’s Syndrome Collaborative Research Group. Lancet 341: 1483–1484

    Article  PubMed  CAS  Google Scholar 

  • Hembree EA, Riggs DS, Kozak MJ, Franklin ME, Foa EB (2003) Long-termefficacy of exposure and ritual prevention therapy and serotonergic medications for obsessive-compulsive disorder. CNS Spectr 8: 363–371, 381

    PubMed  Google Scholar 

  • Hemmings SMJ, Kinnear CJ, Knowles JA, Lochner C, Moolman-Smook H, Niehaus D, Corfield VA, Stein DJ (2003) Early-versus late-onset obsessive compulsive disorder: clinical and genetic correlates. In: Abstracts XIth World Congress of Psychiatric Genetics. Am J Med Genet Part B: Neuropsychiatr Genet 122B(1): 142

    Google Scholar 

  • Himle JA, Fischer DJ, Van Etten ML, Janeck AS, Hanna GL (2003) Group behavioral therapy for adolescents with tic-related and non-tic-related obsessive-compulsive disorder. Depress Anxiety 17: 73–77

    Article  PubMed  Google Scholar 

  • Hoehn-Saric R, Barksdale VC (1983) Impulsiveness in obsessive-compulsive patients. Br J Psychiatry 143: 177–182

    PubMed  CAS  Google Scholar 

  • Hoekstra PJ, Anderson GM, Limburg PC, Korf J, Kallenberg CG, Minderaa RB (2004a) Neurobiology and neuroimmunology of Tourette’s syndrome: an update. Cell Mol Life Sci 61: 886–898

    Article  PubMed  CAS  Google Scholar 

  • Hoekstra PJ, Minderaa RB, Kallenberg CG (2004b) Lack of effect of intravenous immunoglobulins on tics: a double-blind placebo-controlled study. J Clin Psychiatry 65: 537–542

    PubMed  CAS  Google Scholar 

  • Holzer JC, Goodman WK, McDougle CJ, Baer L, Boyarsky BK, Leckman JF, Price LH (1994) Obsessive-compulsive disorder with and without a chronic tic disorder. A comparison of symptoms in 70 patients. Br J Psychiatry 164: 469–473

    PubMed  CAS  Google Scholar 

  • Hood KK, Baptista-Neto L, Beasley PJ, Lobis R, Pravdova I (2004) Case study: severe self-injurious behavior in comorbid Tourette’s disorder and OCD. J Am Acad Child Adolesc Psychiatry 43: 1298–1303

    Article  PubMed  Google Scholar 

  • Hoogduin K, Verdellen C, Cath D (1997) Exposure and response prevention in the treatment of Gilles de la Tourette’s syndrome: four case studies. Clin Psychol Psychother 4: 125–137

    Article  Google Scholar 

  • Hornse H, Banerjee S, Zeitlin H, Robertson M (2001) The prevalence of Tourette syndrome in 13-14-year-olds in mainstream schools. J Child Psychol Psychiatry 42: 1035–1039

    Article  PubMed  CAS  Google Scholar 

  • Hounie AG, Pauls DL, Mercadante MT, Rosario-Campos MC, Shavitt RG, de Mathis MA, de Alvarenga PG, Curi M, Miguel EC (2004) Obsessive-compulsive spectrum disorders in rheumatic fever with and without Sydenham’s chorea. J Clin Psychiatry 65: 994–999

    PubMed  Google Scholar 

  • Hyde TM, Aaronson BA, Randolph C, Rickler KC, Weinberger DR (1992) Relationship of birth weight to the phenotypic expression of Gilles de la Tourette’s syndrome in monozygotic twins. Neurology 42: 652–658

    PubMed  CAS  Google Scholar 

  • Jankovic J (1997) Tourette syndrome. Phenomenology and classification of tics. Neurol Clin 15: 267–275

    Article  PubMed  CAS  Google Scholar 

  • Kadesjo B, Gillberg C (2000) Tourette’s disorder: epidemiology and comorbidity in primary school children. J Am Acad Child Adolesc Psychiatry 39: 548–555

    Article  PubMed  CAS  Google Scholar 

  • Karp BI, Hallett M (1996) Extracorporeal ‘phantom’ tics in Tourette’s syndrome. Neurology 46: 38–40

    PubMed  CAS  Google Scholar 

  • Keck PE Jr, McElroy SL, Strakowski SM, West SA, Sax KW, Hawkins JM, Bourne ML, Haggard P (1998) 12-Month outcome of patients with bipolar disorder following hospitalization for a manic or mixed episode. Am J Psychiatry 155: 646–652

    PubMed  Google Scholar 

  • Khalifa N, von Knorring AL (2003) Prevalence of tic disorders and Tourette syndrome in a Swedish school population. Dev Med Child Neurol 45: 315–319

    Article  PubMed  Google Scholar 

  • Khanna S, Rajendra PN, Channabasavanna SM (1988) Life events and onset of obsessive compulsive disorder. Int J Soc Psychiatry 34: 305–309

    PubMed  CAS  Google Scholar 

  • Kim CH, Koo MS, Cheon KA, Ryu YH, Lee JD, Lee HS (2003) Dopamine transporter density of basal ganglia assessed with [123I]IPT SPET in obsessive-compulsive disorder. Eur J Nucl Med Mol Imaging 30: 1637–1643

    Article  PubMed  CAS  Google Scholar 

  • King RA, Leonard H, March JS (1998) Practice parameters for the assessment and treatment of children and adolescents with obsessive-compulsive disorder. AACAP. J Am Acad Child Adolesc Psychiatry 37: 27S–45S

    Google Scholar 

  • Kopell BH, Greenberg B, Rezai AR (2004) Deep brain stimulation for psychiatric disorders. J Clin Neurophysiol 21: 51–67

    Article  PubMed  Google Scholar 

  • Kuperman S (2002) Tic disorders in the adolescent. Adolesc Med 13: 537–551

    PubMed  Google Scholar 

  • Kurlan R (2004) The PANDAS hypothesis: losing its bite? Mov Disord 19: 371–374

    Article  PubMed  Google Scholar 

  • Kurlan R, Como PG, Deeley C, McDermott M, McDermott MP (1993) A pilot controlled study of fluoxetine for obsessive-compulsive symptoms in children with Tourette’s syndrome. Clin Neuropharmacol 16: 167–172

    PubMed  CAS  Google Scholar 

  • Kurlan R, Como PG, Miller B, Palumbo D, Deeley C, Andresen EM, Eapen S, McDermott MP (2002) The behavioral spectrum of tic disorders: a community-based study. Neurology 59: 414–420

    PubMed  CAS  Google Scholar 

  • Kurlan R, Eapen V, Stern J, McDermott MP, Robertson MM (1994) Bilineal transmission in Tourette’s syndrome families. Neurology 44: 2336–2342

    PubMed  CAS  Google Scholar 

  • Kurlan R, Lichter D, Hewitt D (1989) Sensory tics in Tourette’s syndrome. Neurology 39: 731–734

    PubMed  CAS  Google Scholar 

  • Kwak C, Dat Vuong K, Jankovic J (2003) Premonitory sensory phenomenon in Tourette’s syndrome. Mov Disord 18: 1530–1533

    Article  PubMed  Google Scholar 

  • Lang A (1991) Patient perception of tics and other movement disorders. Neurology 41: 223–228

    PubMed  CAS  Google Scholar 

  • Lanzi G, Zambrino CA, Termine C, Palestra M, Ferrari Ginevra O, Orcesi S, Manfredi P, Beghi E (2004) Prevalence of tic disorders among primary school students in the city of Pavia, Italy. Arch Dis Child 89: 45–47

    PubMed  CAS  Google Scholar 

  • Leckman JF (2002) Tourette’s syndrome. Lancet 360: 1577–1586

    Article  PubMed  Google Scholar 

  • Leckman JF (2003) Phenomenology of tics and natural history of tic disorders. Brain Dev 25(Suppl 1): S24–S28

    Article  PubMed  Google Scholar 

  • Leckman JF, Dolnansky ES, Hardin MT, Clubb M, Walkup JT, Stevenson J, Pauls DL (1990) Perinatal factors in the expression of Tourette’s syndrome: an exploratory study. J Am Acad Child Adolesc Psychiatry 29: 220–226

    PubMed  CAS  Google Scholar 

  • Leckman JF, Grice DE, Barr LC, de Vries AL, Martin C, Cohen DJ, McDougle CJ, Goodman WK, Rasmussen SA (1994a) Tic-related vs. non-tic-related obsessive compulsive disorder. Anxiety 1: 208–215

    PubMed  Google Scholar 

  • Leckman JF, King RA, Cohen DJ (1998a) Tics and tic disorders. In: Leckman JF, Cohen DJ (eds) Tourette’s syndrome — tics, obsessions, compulsions: developmental psychopathology and clinical care. John Wiley and Sons, New York, pp 23–43

    Google Scholar 

  • Leckman JF, McDougle CJ, Pauls DL, Peterson BS, Grice DE, King RA, Scahill L, Price LH, Rasmussen SA (2000) Tic-related versus non-tic-related obsessive-compulsive disorder. In: Goodman WK, Rudorfer MV, Maser JD (eds) Obsessive-compulsive disorder: contemporary issues in treatment. Lawrence Erlbaum Associates, Mahwah, pp 43–68

    Google Scholar 

  • Leckman JF, Peterson BS, Anderson GM, Arnsten AF, Pauls DL, Cohen DJ (1997) Pathogenesis of Tourette’s syndrome. J Child Psychol Psychiatry 38: 119–142

    PubMed  CAS  Google Scholar 

  • Leckman JF, Peterson BS, King RA, Scahill L, Cohen DJ (2001) Phenomenology of tics and natural history of tic disorders. In: Cohen DJ, Goetz CG, Jankovic J (eds) Tourette syndrome. Lippincott, Williams & Wilkins, New York, pp 1–14

    Google Scholar 

  • Leckman JF, Riddle MA, Hardin MT, Ort SI, Swartz KL, Stevenson J, Cohen DJ (1989) The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry 28: 566–573

    PubMed  CAS  Google Scholar 

  • Leckman JF, Walker DE, Cohen DJ (1993) Premonitory urges in Tourette’s syndrome. Am J Psychiatry 150: 98–102

    PubMed  CAS  Google Scholar 

  • Leckman JF, Walker DE, Goodman WK, Pauls DL, Cohen DJ (1994b) ‘Just right’ perceptions associated with compulsive behavior in Tourette’s syndrome. Am J Psychiatry 151: 675–680

    PubMed  CAS  Google Scholar 

  • Leckman JF, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim YS, Peterson BS (1998b) Course of tic severity in Tourette syndrome: the first two decades. Pediatrics 102: 14–19

    Article  PubMed  CAS  Google Scholar 

  • Lees AJ, Robertson M, Trimble MR, Murray NM (1984) A clinical study of Gilles de la Tourette syndrome in the United Kingdom. J Neurol Neurosurg Psychiatry 47: 1–8

    PubMed  CAS  Google Scholar 

  • Leonard HL, Lenane MC, Swedo SE, Rettew DC, Gershon ES, Rapoport JL (1992) Tics and Tourette’s disorder: a 2-to 7-year follow-up of 54 obsessive-compulsive children. Am J Psychiatry 149: 1244–1251

    PubMed  CAS  Google Scholar 

  • Lichter DG, Jackson LA, Schachter M (1995) Clinical evidence of genomic imprinting in Tourette’s syndrome. Neurology 45: 924–928

    PubMed  CAS  Google Scholar 

  • Lin H, Yeh CB, Peterson BS, Scahill L, Grantz H, Findley DB, Katsovich L, Otka J, Lombroso PJ, King RA, Leckman JF (2002) Assessment of symptom exacerbations in a longitudinal study of children with Tourette’s syndrome or obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 41: 1070–1077

    Article  PubMed  Google Scholar 

  • Lombroso PJ, Scahill L, King RA, Lynch KA, Chappell PB, Peterson BS, McDougle CJ, Leckman JF (1995) Risperidone treatment of children and adolescents with chronic tic disorders: a preliminary report. J Am Acad Child Adolesc Psychiatry 34: 1147–1152

    Article  PubMed  CAS  Google Scholar 

  • Lopez-Ibor JJ Jr (1990) Impulse control in obsessive-compulsive disorder: a biopsychopathological approach. Prog Neuropsychopharmacol Biol Psychiatry 14: 709–718

    Article  PubMed  Google Scholar 

  • Luo F, Leckman JF, Katsovich L, Findley D, Grantz H, Tucker DM, Lombroso PJ, King RA, Bessen DE (2004) Prospective longitudinal study of children with tic disorders and/or obsessive-compulsive disorder: relationship of symptom exacerbations to newly acquired streptococcal infections. Pediatrics 113: e578–e585

    Article  PubMed  Google Scholar 

  • Maletzky B, McFarland B, Burt A (1994) Refractory obsessive compulsive disorder and ECT. Convuls Ther 10: 34–42

    PubMed  CAS  Google Scholar 

  • March JS, Franklin M, Nelson A, Foa E (2001) Cognitive-behavioral psychotherapy for pediatric obsessive-compulsive disorder. J Clin Child Psychol 30: 8–18

    Article  PubMed  CAS  Google Scholar 

  • Marcus D, Kurlan R (2001) Tics and its disorders. Neurol Clin 19: 735–758

    Article  PubMed  CAS  Google Scholar 

  • Martin JL, Barbanoj MJ, Perez V, Sacristan M (2003) Transcranial magnetic stimulation for the treatment of obsessive-compulsive disorder. Cochrane Database Syst Rev: CD003387

    Google Scholar 

  • Martino D, Church AJ, Dale RC, Giovannoni G (2004) Antibasal ganglia antibodies and PANDAS. Mov Disord

    Google Scholar 

  • Mason A, Banerjee S, Eapen V, Zeitlin H, Robertson MM (1998) The prevalence of Tourette syndrome in a mainstream school population. Dev Med Child Neurol 40: 292–296

    PubMed  CAS  Google Scholar 

  • Mataix-Cols D, Rauch SL, Baer L, Eisen JL, Shera DM, Goodman WK, Rasmussen SA, Jenike MA (2002) Symptom stability in adult obsessive-compulsive disorder: data from a naturalistic two-year follow-up study. Am J Psychiatry 159: 263–268

    Article  PubMed  Google Scholar 

  • Mataix-Cols D, Rauch SL, Manzo PA, Jenike MA, Baer L (1999) Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder. Am J Psychiatry 156: 1409–1416

    PubMed  CAS  Google Scholar 

  • Mathews CA, Waller J, Glidden D, Lowe TL, Herrera LD, Budman CL, Erenberg G, Naarden A, Bruun RD, Freimer NB, Reus VI (2004) Self injurious behaviour in Tourette syndrome: correlates with impulsivity and impulse control. J Neurol Neurosurg Psychiatry 75: 1149–1155

    Article  PubMed  CAS  Google Scholar 

  • McDougle CJ, Goodman WK, Leckman JF, Barr LC, Heninger GR, Price LH (1993) The efficacy of fluvoxamine in obsessive-compulsive disorder: effects of comorbid chronic tic disorder. J Clin Psychopharmacol 13: 354–358

    PubMed  CAS  Google Scholar 

  • McDougle CJ, Goodman WK, Leckman JF, Lee NC, Heninger GR, Price LH (1994) Haloperidol addition in fluvoxamine-refractory obsessive-compulsive disorder. A double-blind, placebo-controlled study in patients with and without tics. Arch Gen Psychiatry 51: 302–308

    PubMed  CAS  Google Scholar 

  • Mellman LA, Gorman JM (1984) Successful treatment of obsessive-compulsive disorder with ECT. Am J Psychiatry 141: 596–597

    PubMed  CAS  Google Scholar 

  • Miguel EC, Baer L, Coffey BJ, Rauch SL, Savage CR, O’sullivan RL, Phillips K, Moretti C, Leckman JF, Jenike MA (1997) Phenomenological differences appearing with repetitive behaviours in obsessive-compulsive disorder and Gilles de la Tourette’s syndrome. Br J Psychiatry 170: 140–145

    PubMed  CAS  Google Scholar 

  • Miguel EC, do Rosario-Campos MC, Prado HS, do Valle R, Rauch SL, Coffey BJ, Baer L, Savage CR, O’sullivan RL, Jenike MA, Leckman JF (2000) Sensory phenomena in obsessive-compulsive disorder and Tourette’s disorder. J Clin Psychiatry 61: 150–156; quiz 157

    PubMed  CAS  Google Scholar 

  • Miguel EC, do Rosario-Campos MC, Shavitt RG, Hounie AG, Mercadante MT (2001) The ticrelated obsessive-compulsive disorder phenotype and treatment implications. Adv Neurol 85: 43–55

    PubMed  CAS  Google Scholar 

  • Miguel EC, Shavitt RG, Ferrao YA, Brotto SA, Diniz JB (2003) How to treat OCD in patients with Tourette syndrome. J Psychosom Res 55: 49–57

    Article  PubMed  Google Scholar 

  • Millet B, Chabane N, Delorme R, Leboyer M, Leroy S, Poirier MF, Bourdel MC, Mouren-Simeoni MC, Rouillon F, Loo H, Krebs MO (2003) Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder. Am J Med Genet 116B: 55–59

    Article  PubMed  Google Scholar 

  • Mink JW (2001) Neurobiology of basal ganglia circuits in Tourette syndrome: faulty inhibition of unwanted motor patterns? Adv Neurol 85: 113–122

    PubMed  CAS  Google Scholar 

  • Moll GH, Eysenbach K, Woerner W, Banaschewski T, Schmidt MH, Rothenberger A (2000) Quantitative and qualitative aspects of obsessive-compulsive behaviour in children with attention-deficit hyperactivity disorder compared with tic disorder. Acta Psychiatr Scand 101: 389–394

    Article  PubMed  CAS  Google Scholar 

  • Moll GH, Rothenberger A (1999) [Relationship between tics and compulsion]. Nervenarzt 70: 1–10

    Article  PubMed  CAS  Google Scholar 

  • Moriarty J, Eapen V, Costa DC, Gacinovic S, Trimble M, Ell PJ, Robertson MM (1997) HMPAO SPET does not distinguish obsessive-compulsive and tic syndromes in families multiply affected with Gilles de la Tourette’s syndrome. Psychol Med 27: 737–740

    Article  PubMed  CAS  Google Scholar 

  • Müller SV, Johannes S, Wieringa B, Weber A, Muller-Vahl K, Matzke M, Kolbe H, Dengler R, Munte TF (2003) Disturbed monitoring and response inhibition in patients with Gilles de la Tourette syndrome and co-morbid obsessive compulsive disorder. Behav Neurol 14: 29–37

    PubMed  Google Scholar 

  • Murphy ML, Pichichero ME (2002) Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS). Arch Pediatr Adolesc Med 156: 356–361

    PubMed  Google Scholar 

  • Murphy TK, Sajid M, Soto O, Shapira N, Edge P, Yang M, Lewis MH, Goodman WK (2004) Detecting pediatric autoimmune neuropsychiatric disorders associated with streptococcus in children with obsessive-compulsive disorder and tics. Biol Psychiatry 55: 61–68

    Article  PubMed  Google Scholar 

  • Nee LE, Caine ED, Polinsky RJ, Eldridge R, Ebert MH (1980) Gilles de la Tourette syndrome: clinical and family study of 50 cases. Ann Neurol 7: 41–49

    Article  PubMed  CAS  Google Scholar 

  • Nestadt G, Addington A, Samuels J, Liang KY, Bienvenu OJ, Riddle M, Grados M, Hoehn-Saric R, Cullen B (2003) The identification of OCD-related subgroups based on comorbidity. Biol Psychiatry 53: 914–920

    Article  PubMed  Google Scholar 

  • Nestadt G, Samuels J, Riddle M, Bienvenu OJ 3rd, Liang KY, LaBuda M, Walkup J, Grados M, Hoehn-Saric R (2000) A family study of obsessive-compulsive disorder. Arch Gen Psychiatry 57: 358–363

    Article  PubMed  CAS  Google Scholar 

  • Neziroglu F, Anemone R, Yaryura-Tobias JA (1992) Onset of obsessive-compulsive disorder in pregnancy. Am J Psychiatry 149: 947–950

    PubMed  CAS  Google Scholar 

  • Nicolini H, Cruz C, Paez F, Camarena B (1998) [Dopamine D2 and D4 receptor genes distinguish the clinical presence of tics in obsessive-compulsive disorder]. Gac Med Mex 134: 521–527

    PubMed  CAS  Google Scholar 

  • Nomoto F, Machiyama Y (1990) An epidemiological study of tics. Jpn J Psychiatry Neurol 44: 649–655

    PubMed  CAS  Google Scholar 

  • Nordstrom EJ, Burton FH (2002) A transgenic model of comorbid Tourette’s syndrome and obsessive-compulsive disorder circuitry. Mol Psychiatry 7: 617–625, 524

    Article  PubMed  CAS  Google Scholar 

  • O’Connor KP (2001) Clinical and psychological features distinguishing obsessive-compulsive and chronic tic disorders. Clin Psychol Rev 21: 631–660

    Article  PubMed  CAS  Google Scholar 

  • Palumbo D, Maughan A, Kurlan R (1997) Hypothesis III. Tourette syndrome is only one of several causes of a developmental basal ganglia syndrome. Arch Neurol 54: 475–483

    PubMed  CAS  Google Scholar 

  • Pappert EJ, Goetz CG, Louis ED, Blasucci L, Leurgans S (2003) Objective assessments of longitudinal outcome in Gilles de la Tourette’s syndrome. Neurology 61: 936–940

    PubMed  CAS  Google Scholar 

  • Pauls DL (2003) An update on the genetics of Gilles de la Tourette syndrome. J Psychosom Res 55: 7–12

    Article  PubMed  Google Scholar 

  • Pauls DL, Alsobrook JP, Almasy L, Leckman JF, Cohen DJ (1991a) Genetic and epidemiological analyses of the Yale Tourette’s Syndrome Family Study data. Psychiatr Genet 2: 28

    Google Scholar 

  • Pauls DL, Alsobrook JP 2nd, Goodman W, Rasmussen S, Leckman JF (1995) A family study of obsessive-compulsive disorder. Am J Psychiatry 152: 76–84

    PubMed  CAS  Google Scholar 

  • Pauls DL, Leckman JF (1986) The inheritance of Gilles de la Tourette’s syndrome and associated behaviors. Evidence for autosomal dominant transmission. N Engl J Med 315: 993–997

    Article  PubMed  CAS  Google Scholar 

  • Pauls DL, Raymond CL, Stevenson JM, Leckman JF (1991b) A family study of Gilles de la Tourette syndrome. Am J Hum Genet 48: 154–163

    PubMed  CAS  Google Scholar 

  • Perugi G, Akiskal HS, Gemignani A, Pfanner C, Presta S, Milanfranchi A, Lensi P, Ravagli S, Maremmani I, Cassano GB (1998) Episodic course in obsessive-compulsive disorder. Eur Arch Psychiatry Clin Neurosci 248: 240–244

    Article  PubMed  CAS  Google Scholar 

  • Peterson BS (2001c) Neuroimaging studies of Tourette syndrome: a decade of progress. Adv Neurol 85: 179–196

    Article  PubMed  CAS  Google Scholar 

  • Peterson BS, Leckman JF (1998) The temporal dynamics of tics in Gilles de la Tourette syndrome. Biol Psychiatry 44: 1337–1348

    Article  PubMed  CAS  Google Scholar 

  • Peterson BS, Pine DS, Cohen P, Brook JS (2001a) Prospective, longitudinal study of tic, obsessive-compulsive, and attention-deficit/hyperactivity disorders in an epidemiological sample. J Am Acad Child Adolesc Psychiatry 40: 685–695

    Article  PubMed  CAS  Google Scholar 

  • Peterson BS, Staib L, Scahill L, Zhang H, Anderson C, Leckman JF, Cohen DJ, Gore JC, Albert J, Webster R (2001b) Regional brain and ventricular volumes in Tourette syndrome. Arch Gen Psychiatry 58: 427–440

    Article  PubMed  CAS  Google Scholar 

  • Peterson BS, Thomas P, Kane MJ, Scahill L, Zhang H, Bronen R, King RA, Leckman JF, Staib L (2003) Basal ganglia volumes in patients with Gilles de la Tourette syndrome. Arch Gen Psychiatry 60: 415–424

    Article  PubMed  Google Scholar 

  • Piacentini J, Bergman RL, Jacobs C, McCracken JT, Kretchman J (2002) Open trial of cognitive behavior therapy for childhood obsessive-compulsive disorder. J Anxiety Disord 16: 207–219

    Article  PubMed  Google Scholar 

  • Price RA, Kidd KK, Cohen DJ, Pauls DL, Leckman JF (1985) A twin study of Tourette syndrome. Arch Gen Psychiatry 42: 815–820

    PubMed  CAS  Google Scholar 

  • Rapoport M, Feder V, Sandor P (1998) Response of major depression and Tourette’s syndrome to ECT: a case report. Psychosom Med 60: 528–529

    PubMed  CAS  Google Scholar 

  • Rauch SL, Whalen PJ, Curran T, Shin LM, Coffey BJ, Savage CR, McInerney SC, Baer L, Jenike MA (2001) Probing striato-thalamic function in obsessive-compulsive disorder and Tourette syndrome using neuroimaging methods. Adv Neurol 85: 207–224

    PubMed  CAS  Google Scholar 

  • Ravizza L, Barzega G, Bellino S, Bogetto F, Maina G (1995) Predictors of drug treatment response in obsessive-compulsive disorder. J Clin Psychiatry 56: 368–373

    PubMed  CAS  Google Scholar 

  • Ravizza L, Maina G, Bogetto F (1997) Episodic and chronic obsessive-compulsive disorder. Depress Anxiety 6: 154–158

    Article  PubMed  CAS  Google Scholar 

  • Ravizza L, Maina G, Torta RFB (1991) Are serotonergic antidepressants more effective in episodic’ obsessive-compulsive disorder? In: Cassano GB, Akiskal HS (eds) Serotoninrelated psychiatric syndromes: clinical and therapeutic links. Royal Society of Medicine Services, London, pp 61–65

    Google Scholar 

  • Robertson MM (1989) The Gilles de la Tourette syndrome: the current status. Br J Psychiatry 154: 147–169

    Article  PubMed  CAS  Google Scholar 

  • Robertson MM (1994) Annotation: Gilles de la Tourette syndrome-an update. J Child Psychol Psychiatry 35: 597–611

    PubMed  CAS  Google Scholar 

  • Robertson MM (2000) Tourette syndrome, associated conditions and the complexities of treatment. Brain 123Pt 3: 425–462

    Article  PubMed  Google Scholar 

  • Robertson MM, Banerjee S, Kurlan R, Cohen DJ, Leckman JF, McMahon W, Pauls DL, Sandor P, van de Wetering BJ (1999) The Tourette syndrome diagnostic confidence index: development and clinical associations. Neurology 53: 2108–2112

    PubMed  CAS  Google Scholar 

  • Robertson MM, Gourdie A (1990) Familial Tourette’s syndrome in a large British pedigree. Associated psychopathology, severity, and potential for linkage analysis. Br J Psychiatry 156: 515–521

    PubMed  CAS  Google Scholar 

  • Robertson MM, Trimble MR, Lees AJ (1988) The psychopathology of the Gilles de la Tourette syndrome. A phenomenological analysis. Br J Psychiatry 152: 383–390

    PubMed  CAS  Google Scholar 

  • Robertson MM, Trimble MR, Lees AJ (1989) Self-injurious behaviour and the Gilles de la Tourette syndrome: a clinical study and review of the literature. Psychol Med 19: 611–625

    Article  PubMed  CAS  Google Scholar 

  • Roessner V, Banaschewski T, Rothenberger A (2004) Therapy of tic-disorders. Z Kinder Jugendpsychiatr Psychother 32: 245–263

    Article  PubMed  Google Scholar 

  • Rosario-Campos MC, Leckman JF, Mercadante MT, Shavitt RG, Prado HS, Sada P, Zamignani D, Miguel EC (2001) Adults with early-onset obsessive-compulsive disorder. Am J Psychiatry 158: 1899–1903

    Article  PubMed  CAS  Google Scholar 

  • Rosenberg LA, Brown J, Singer HS (1995) Behavioral problems and severity of tics. J Clin Psychol 51: 760–767

    PubMed  CAS  Google Scholar 

  • Rothenberger A, Banaschewski T (2004) Tic-disorders. In: Grillberg C, Harrington R, Steinhausen HC (eds) A clinican’s handbook of child and adolsecent psychiatry. Cambridge University Press, Cambridge

    Google Scholar 

  • Rothenberger A, Banaschewski T, Roessner V (2005) Tic-Störungen. In: Herpetz-Dahlmann B, Resch F, Schulte-Markwort M, Warnke A (eds) Entwicklungspsychiatrie. Schattauer, Stuttgart

    Google Scholar 

  • Saba PR, Dastur K, Keshavan MS, Katerji MA (1998) Obsessive-compulsive disorder, Tourette’s syndrome, and basal ganglia pathology on MRI. J Neuropsychiatr Clin Neurosci 10: 116–117

    CAS  Google Scholar 

  • Sachdev PS, McBride R, Loo CK, Mitchell PB, Malhi GS, Croker VM (2001) Right versus left prefrontal transcranial magnetic stimulation for obsessive-compulsive disorder: a preliminary investigation. J Clin Psychiatry 62: 981–984

    Article  PubMed  CAS  Google Scholar 

  • Santangelo SL, Pauls DL, Goldstein JM, Faraone SV, Tsuang MT, Leckman JF (1994) Tourette’s syndrome: what are the influences of gender and comorbid obsessive-compulsive disorder? J Am Acad Child Adolesc Psychiatry 33: 795–804

    PubMed  CAS  Google Scholar 

  • Saxena S, Rauch SL (2000) Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin North Am 23: 563–586

    Article  PubMed  CAS  Google Scholar 

  • Scahill L, Chappell PB, King RA, Leckman JF (2000) Pharmacologic treatment of tic disorders. Child Adolesc Psychiatr Clin North Am 9: 99–117

    CAS  Google Scholar 

  • Scahill L, Riddle MA, King RA, Hardin MT, Rasmusson A, Makuch RW, Leckman JF (1997) Fluoxetine has no marked effect on tic symptoms in patients with Tourette’s syndrome: a double-blind placebo-controlled study. J Child Adolesc Psychopharmacol 7: 75–85

    PubMed  CAS  Google Scholar 

  • Scahill L, Tanner C, Dure L (2001) The epidemiology of tics and Tourette syndrome in children and adolescents. Adv Neurol 85: 261–271

    PubMed  CAS  Google Scholar 

  • Scahill LD, Leckman JF, Marek KL (1995) Sensory phenomena in Tourette’s syndrome. Adv Neurol 65: 273–280

    PubMed  CAS  Google Scholar 

  • Schoenian S, Konig I, Oertel W, Remschmidt H, Ziegler A, Hebebrand J, Bandmann O (2003) HLA-DRB genotyping in Gilles de la Tourette patients and their parents. Am J Med Genet 119B: 60–64

    Article  PubMed  Google Scholar 

  • Seuchter SA, Hebebrand J, Klug B, Knapp M, Lehmkuhl G, Poustka F, Schmidt M, Remschmidt H, Baur MP (2000) Complex segregation analysis of families ascertained through Gilles de la Tourette syndrome. Genet Epidemiol 18: 33–47

    Article  PubMed  CAS  Google Scholar 

  • Shapiro AK, Shapiro ES, Young JG, Feinberg TE (1988) Gilles de la Tourette Syndrome. Raven Press, New York

    Google Scholar 

  • Silva RR, Munoz DM, Barickman J, Friedhoff AJ (1995) Environmental factors and related fluctuation of symptoms in children and adolescents with Tourette’s disorder. J Child Psychol Psychiatry 36: 305–312

    PubMed  CAS  Google Scholar 

  • Singer HS, Giuliano JD, Zimmerman AM, Walkup JT (2000) Infection: a stimulus for tic disorders. Pediatr Neurol 22: 380–383

    Article  PubMed  CAS  Google Scholar 

  • Singer HS, Loiselle CR, Lee O, Minzer K, Swedo S, Grus FH (2004) Anti-basal ganglia antibodies in PANDAS. Mov Disord 19: 406–415

    Article  PubMed  Google Scholar 

  • Singer HS, Walkup JT (1991) Tourette syndrome and other tic disorders. Diagnosis, pathophysiology, and treatment. Medicine (Baltimore) 70: 15–32

    PubMed  CAS  Google Scholar 

  • Snider LA, Swedo SE (2003) Childhood-onset obsessive-compulsive disorder and tic disorders: case report and literature review. J Child Adolesc Psychopharmacol 13(Suppl 1): S81–S88

    Article  PubMed  Google Scholar 

  • Stefl ME (1984) Mental health needs associated with Tourette syndrome. Am J Publ Health 74: 1310–1313

    Article  CAS  Google Scholar 

  • Stein DJ, Hollander E, Simeon D, Cohen L (1994) Impulsivity scores in patients with obsessive-compulsive disorder. J Nerv Ment Dis 182: 240–241

    PubMed  CAS  Google Scholar 

  • Steketee G, Eisen J, Dyck I, Warshaw M, Rasmussen S (1999) Predictors of course in obsessive-compulsive disorder. Psychiatry Res 89: 229–238

    Article  PubMed  CAS  Google Scholar 

  • Stephens RJ, Bassel C, Sandor P (2004) Olanzapine in the treatment of aggression and tics in children with Tourette’s syndrome — a pilot study. J Child Adolesc Psychopharmacol 14: 255–266

    Article  PubMed  Google Scholar 

  • Stephens RJ, Sandor P (1999) Aggressive behaviour in children with Tourette syndrome and comorbid attention-deficit hyperactivity disorder and obsessive-compulsive disorder. Can J Psychiatry 44: 1036–1042

    PubMed  CAS  Google Scholar 

  • Stewart SE, Geller DA, Jenike M, Pauls D, Shaw D, Mullin B, Faraone SV (2004) Long-term outcome of pediatric obsessive-compulsive disorder: a meta-analysis and qualitative review of the literature. Acta Psychiatr Scand 110: 4–13

    Article  PubMed  CAS  Google Scholar 

  • Stober G, Hebebrand J, Cichon S, Bruss M, Bonisch H, Lehmkuhl G, Poustka F, Schmidt M, Remschmidt H, Propping P, Nothen MM (1999) Tourette syndrome and the norepinephrine transporter gene: results of a systematic mutation screening. Am J Med Genet 88: 158–163

    Article  PubMed  CAS  Google Scholar 

  • Stokes A, Bawden HN, Camfield PR, Backman JE, Dooley JM (1991) Peer problems in Tourette’s disorder. Pediatrics 87: 936–942

    PubMed  CAS  Google Scholar 

  • Strassnig M, Riedel M, Muller N (2004) Electroconvulsive therapy in a patient with Tourette’s syndrome and co-morbid obsessive compulsive disorder. World J Biol Psychiatry 5: 164–166

    Article  PubMed  Google Scholar 

  • Sukhodolsky DG, Scahill L, Zhang H, Peterson BS, King RA, Lombroso PJ, Katsovich L, Findley D, Leckman JF (2003) Disruptive behavior in children with Tourette’s syndrome: association with ADHD comorbidity, tic severity, and functional impairment. J Am Acad Child Adolesc Psychiatry 42: 98–105

    Article  PubMed  Google Scholar 

  • Swedo SE, Leonard HL, Garvey M, Mittleman B, Allen AJ, Perlmutter S, Lougee L, Dow S, Zamkoff J, Dubbert BK (1998) Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry 155: 264–271

    PubMed  CAS  Google Scholar 

  • Swerdlow NR (2001) Obsessive-compulsive disorder and tic syndromes. Med Clin North Am 85: 735–755

    Article  PubMed  CAS  Google Scholar 

  • Swerdlow NR, Gierz M, Berkowitz A, Nemiroff R, Lohr J (1990) Electroconvulsive therapy in a patient with severe tic disorder and major depressive episode. J Clin Psychiatry 51: 34–35

    PubMed  CAS  Google Scholar 

  • Swerdlow NR, Zinner S, Farber RH, Seacrist C, Hartston HJ (1999) Symptoms in obsessive-compulsive disorder and Tourette syndrome: a spectrum? CNS Spectrums 4: 21–33

    Google Scholar 

  • Tass PA, Klosterkotter J, Schneider F, Lenartz D, Koulousakis A, Sturm V (2003) Obsessive-compulsive disorder: development of demand-controlled deep brain stimulation with methods from stochastic phase resetting. Neuropsychopharmacology 28(Suppl 1): S27–S34

    Article  PubMed  Google Scholar 

  • Tekin S, Cummings JL (2002) Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update. J Psychosom Res 53: 647–654

    Article  PubMed  Google Scholar 

  • Thomas SG, Kellner CH (2003) Remission of major depression and obsessive-compulsive disorder after a single unilateral ECT. J Ect 19: 50–51

    Article  PubMed  Google Scholar 

  • Tolin DF, Abramowitz JS, Przeworski A, Foa EB (2002) Thought suppression in obsessive-compulsive disorder. Behav Res Ther 40: 1255–1274

    Article  PubMed  Google Scholar 

  • Tolin DF, Maltby N, Diefenbach GJ, Hannan SE, Worhunsky P (2004) Cognitive-behavioral therapy for medication nonresponders with obsessive-compulsive disorder: a wait-list-controlled open trial. J Clin Psychiatry 65: 922–931

    Article  PubMed  Google Scholar 

  • Trivedi HK, Mendelowitz AJ, Fink M (2003) Gilles de la Tourette form of catatonia: response to ECT. J Ect 19: 115–117

    Article  PubMed  Google Scholar 

  • Turpin G (1983) The behavioural management of tic disorders: a critical review. Adv Behav Res Ther 5: 203–245

    Article  Google Scholar 

  • Urraca N, Camarena B, Gomez-Caudillo L, Esmer MC, Nicolini H (2004) Mu opioid receptor gene as a candidate for the study of obsessive compulsive disorder with and without tics. Am J Med Genet 127B: 94–96

    Article  CAS  PubMed  Google Scholar 

  • Vandenbergh DJ, Thompson MD, Cook EH, Bendahhou E, Nguyen T, Krasowski MD, Zarrabian D, Comings D, Sellers EM, Tyndale RF, George SR, O’Dowd BF, Uhl GR (2000) Human dopamine transporter gene: coding region conservation among normal, Tourette’s disorder, alcohol dependence and attention-deficit hyperactivity disorder populations. Mol Psychiatry 5: 283–292

    Article  PubMed  CAS  Google Scholar 

  • Van Noppen B, Steketee G, McCorkle BH, Pato M (1997) Group and multifamily behavioral treatment for obsessive compulsive disorder: a pilot study. J Anxiety Disord 11: 431–446

    Article  PubMed  Google Scholar 

  • Verdellen CW, Keijsers GP, Cath DC, Hoogduin CA (2004) Exposure with response prevention versus habit reversal in Tourettes’s syndrome: a controlled study. Behav Res Ther 42: 501–511

    Article  PubMed  Google Scholar 

  • Verhulst FC, van der Ende J, Ferdinand RF, Kasius MC (1997) The prevalence of DSM-III-R diagnoses in a national sample of Dutch adolescents. Arch Gen Psychiatry 54: 329–336

    PubMed  CAS  Google Scholar 

  • Visser-Vandewalle V, Temel Y, van der Linden Ch, Ackermans L, Beuls E (2004) Deep brain stimulation in movement disorders. The applications reconsidered. Acta Neurol Belg 104: 33–36

    PubMed  CAS  Google Scholar 

  • Walkup JT, LaBuda MC, Singer HS, Brown J, Riddle MA, Hurko O (1996) Family study and segregation analysis of Tourette syndrome: evidence for a mixed model of inheritance. Am J Hum Genet 59: 684–693

    PubMed  CAS  Google Scholar 

  • Walkup JT, Rosenberg LA, Brown J, Singer HS (1992) The validity of instruments measuring tic severity in Tourette’s syndrome. J Am Acad Child Adolesc Psychiatry 31: 472–477

    PubMed  CAS  Google Scholar 

  • Wang HS, Kuo MF (2003) Tourette’s syndrome in Taiwan: an epidemiological study of tic disorders in an elementary school at Taipei County. Brain Dev 25(Suppl 1): S29–S31

    Article  PubMed  Google Scholar 

  • Wilhelm S, Deckersbach T, Coffey BJ, Bohne A, Peterson AL, Baer L (2003) Habit reversal versus supportive psychotherapy for Tourette’s disorder: a randomized controlled trial. Am J Psychiatry 160: 1175–1177

    Article  PubMed  Google Scholar 

  • Woods DW, Twohig MP, Flessner CA, Roloff TJ (2003) Treatment of vocal tics in children with Tourette syndrome: investigating the efficacy of habit reversal. J Appl Behav Anal 36: 109–112

    Article  PubMed  Google Scholar 

  • Xu C, Ozbay F, Wigg K, Shulman R, Tahir E, Yazgan Y, Sandor P, Barr CL (2003) Evaluation of the genes for the adrenergic receptors alpha 2A and alpha 1C and Gilles de la Tourette Syndrome. Am J Med Genet 119B: 54–59

    Article  PubMed  Google Scholar 

  • Yaryura-Tobias JA, Rabinowitz DC, Neziroglu F (2003) Possible basal ganglia pathology in children with complex symptoms. J Clin Psychiatry 64: 1495–1501

    Article  PubMed  Google Scholar 

  • Zhang H, Leckman JF, Pauls DL, Tsai CP, Kidd KK, Campos MR (2002) Genomewide scan of hoarding in sib pairs in which both sibs have Gilles de la Tourette syndrome. Am J Hum Genet 70: 896–904

    Article  PubMed  CAS  Google Scholar 

  • Ziemann U, Paulus W, Rothenberger A (1997) Decreased motor inhibition in Tourette’s disorder: evidence from transcranial magnetic stimulation. Am J Psychiatry 154: 1277–1284

    PubMed  CAS  Google Scholar 

  • Zohar AH, Pauls DL, Ratzoni G, Apter A, Dycian A, Binder M, King R, Leckman JF, Kron S, Cohen DJ (1997) Obsessive-compulsive disorder with and without tics in an epidemiological sample of adolescents. Am J Psychiatry 154: 274–276

    PubMed  CAS  Google Scholar 

  • Zohar AH, Ratzoni G, Pauls DL, Apter A, Bleich A, Kron S, Rappaport M, Weizman A, Cohen DJ (1992) An epidemiological study of obsessive-compulsive disorder and related disorders in Israeli adolescents. J Am Acad Child Adolesc Psychiatry 31: 1057–1061

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Child and Adolescent Psychiatry, University of Göttingen, Von-Siebold-Strasse 5, 37075, Göttingen, Germany

    Dr. V. Roessner, A. Becker, T. Banaschewski & A. Rothenberger

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  1. Dr. V. Roessner
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  2. A. Becker
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  3. T. Banaschewski
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  4. A. Rothenberger
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  1. Department of Biological Psychiatry, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria

    W. W. Fleischhacker

  2. Division of Neurocience and MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK

    D. J. Brooks

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Roessner, V., Becker, A., Banaschewski, T., Rothenberger, A. (2005). Tic disorders and obsessive compulsive disorder: where is the link?. In: Fleischhacker, W.W., Brooks, D.J. (eds) Neurodevelopmental Disorders. Springer, Vienna. https://doi.org/10.1007/3-211-31222-6_5

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