Chronic Urticaria as an Autoimmune Disease

  • Michihiro Hide
  • Malcolm W. Greaves


Allergy Clin Immunol Chronic Urticaria Chronic Idiopathic Urticaria Urticarial Vasculitis Autologous Serum Skin Test 
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  1. Adachi J, Aoki T, Yamatodani A (1994) Demonstration of sweat allergy in cholinergic urticaria. J Dermatol Sci 7: 142–149PubMedGoogle Scholar
  2. Adams DD (1988) Long-acting thyroid stimulator: how receptor autoimmunity was discovered. J Autoimmunity 1: 3–9CrossRefGoogle Scholar
  3. Asero R, Tedeschi A, Lorni M, Salimbeni R, Zanoletti T, Miadonna A (2001) Chronic urticaria: novel clinical and serological aspects. Clin Exp Allergy 31: 1105–1110CrossRefPubMedGoogle Scholar
  4. Bentley-Phillips CB, Black AK, Greaves MW (1976) Induced tolerance in cold urticaria caused by cold-evoked histamine release. Lancet ii: 63–66CrossRefGoogle Scholar
  5. Black AK, Lawlor F, Greaves MW (1996) Consensus meeting on the definition of physical urticarias and urticarial vasculitis. Clin Exp Dermatol 21: 424–426PubMedGoogle Scholar
  6. Black, AK, Physical and Cholinergic Urticarias. In: Urticaria and Angioedema. Eds Malcolm W Greaves, Allen P Kaplan. Marcel Dekker, New York, (2004) chapter 8, pp 171–214Google Scholar
  7. Burova GP, Mallet AI, Greaves MW (1998) Is Helicobacter pylori a cause of chronic urticaria? Br J Dermatol 139(Suppl): 42Google Scholar
  8. Caproni M, Volpi W, Macchia D, Giomi B, Manfredi M, Campi P, Cardinali C, D’Agata A, Fabbri P. (2003) Infiltrating cells and related cytokines in lesional skin of patients with chronic idiopathic urticaria and positive autologous serum skin test. Exp Dermatol 2:621–628CrossRefGoogle Scholar
  9. Commens CA, Greaves MW (1978) Tests to establish the diagnosis in cholinergic urticaria. Brit J Dermatol 98: 47–51Google Scholar
  10. Erbagci Z (2002) The leukotriene receptor antagonist montelukast in the treatment of chronic idiopathic urticaria: a single-blind, placebo-controlled, crossover clinical study. J Allergy Clin Immunol 110: 484–848CrossRefPubMedGoogle Scholar
  11. Fagiolo U, Kricek F, Ruf C, Peserico A, Amadori A, Cancian M.(2000) Effects of complement inactivation and IgG depletion on skin reactivity to autologous serum in chronic idiopathic urticaria. J Allergy Clin Immunol 106: 567–572CrossRefPubMedGoogle Scholar
  12. Ferrer M, Kinet JP, Kaplan AP (1998) Comparative studies of functional and binding assays for IgG anti-FcɛRIαh (α-subunit) in chronic urticaria. J Allergy Clin Immunol 101: 672–676PubMedGoogle Scholar
  13. Fiebiger E, Maurer D, Holubar H, Reininger B, Hartmann G, Woisetschlager M, Stingl G (1995) Serum IgG autoantibodies directed against the alpha chain of FcɛRI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients. J Clin Invest 96: 2606–2612PubMedGoogle Scholar
  14. Fiebiger E, Hammerschmid F, Stingl G, Maurer D (1998) Anti-FcɛRIα autoantibodies in autoimmune-mediated disorders. J Clin Invest 101: 243–261PubMedGoogle Scholar
  15. Fung-Leung W-P, Sousa-Hitzien JD, Ishaque A (1996) Transgenic mice expressing the human high affinity immunoglobulin (Ig)E receptor α chain, respond to human IgE in mast cell degranulation and allergic reactions. J Exp Med 183: 49–56CrossRefPubMedGoogle Scholar
  16. Grattan CEH, Wallington TB, Warin RP (1986) A serological mediator in chronic idiopathic urticaria: a clinical immunological and histological evaluation. Br J Dermatol 114: 583–590PubMedGoogle Scholar
  17. Grattan CEH, Francis DM, Hide M, Greaves MW (1991) Detection of circulating histamine releasing autoantibodies with functional properties of anti-IgE in chronic urticaria. Clin Exp Allergy 21: 695–704PubMedGoogle Scholar
  18. Grattan CEH, Francis DM, Slater NGP, Greaves MW (1992) Plasmapheresis for severe unremitting chronic urticaria. Lancet 339: 1078–1080CrossRefPubMedGoogle Scholar
  19. Grattan CEH, Francis DM (1999) Autoimmune urticaria. Advances Dermatol 15, 311–340Google Scholar
  20. Grattan CEH, O’Donnell BF, Francis DM, Niimi N, Barlow RJ, Seed PT, Black AK, Greaves MW (2000) Randomised double blind study of cyclosporin in chronic idiopathic urticaria. Br J Dermatol 143: 365–372CrossRefPubMedGoogle Scholar
  21. Grattan CEH (2003) Aspirin sensitivity and urticaria. Clin Exp Dermatol 28: 123–127CrossRefPubMedGoogle Scholar
  22. Greaves MW (1995) Current concepts in chronic urticaria. New Eng J Med 332: 1767–1772CrossRefPubMedGoogle Scholar
  23. Greaves MW (2000a) Management of urticaria. Hosp Med 61: 463–469PubMedGoogle Scholar
  24. Greaves MW (2000b) Chronic urticaria. J Allergy Clin Immunol 105: 664–672CrossRefPubMedGoogle Scholar
  25. Greaves MW (2001) Chronic idiopathic urticaria (CIU) and Helicobacter pylori — not directly causative, but could there be a link? Allergy Clin Immunol Internat 13: 23–26Google Scholar
  26. Hayashi S Hashimoto S (1999) Anti-inflammatory actions of new antihistamines. Clin Exp Allergy 29: 1593–1596CrossRefPubMedGoogle Scholar
  27. Henz BM, Zuberbier T. Causes of urticaria. pp 20–38. in Urtcaria eds Henz BM, Zuberbier T, Grabbe J, Monroe E. Springer, Verlag Berlin Heidelberg 1998Google Scholar
  28. Herxheimer A (1956) The nervous pathway mediating cholinergic urticaria. Clin Sci 15:195–205PubMedGoogle Scholar
  29. Hide M, Francis DM, Grattan CH, Greaves MW (1993) Autoantibodies against the high affinity IgE receptor as a cause for histamine release in chronic urticaria. New Eng J Med 328:1599–1604CrossRefPubMedGoogle Scholar
  30. Hide M, Francis DM, Grattan CEH, Barr RM, Winkelmann RK, Greaves MW (1994) The pathogenesis of chronic urticaria: new evidence suggests an autoimmune basis and implications for treatment. Clin Exp Allergy 24: 624–627PubMedGoogle Scholar
  31. Hide M, Francis DM, Barr RM and Greaves MW (1995). Skin mast cell activation by autoantibodies in urticaria and therapeutic implications. in Biological and Molecular Aspects of Mast Cell and Basophil Differentiation and Function. eds. Kitamura Y, Yamamoto S, Galli SJ, Greaves MW. pp 183–192, Raven Press, New YorkGoogle Scholar
  32. Hirschmann JV, Lawlor F, English SJC, Lowback JB, Winkelmann RK, Greaves MW (1987) Cholinergic urticaria. Arch Dermatol 123: 462–467CrossRefPubMedGoogle Scholar
  33. Holgate ST Bradding P Sampson AP (1996) Leukotriene antagonists and synthesis inhibitors: new directions in asthma therapy. J Allergy Clin Immunol 98: 1–13PubMedGoogle Scholar
  34. Horn MP, Gerster T, Ochensberger B, Derer T, Kricek F, Jouvin MH, Kinet JP, Tschernig T, Vogel M, Stadler BM, Miescher SM (1999) Human anti-FcepsilonRIalpha autoantibodies isolated from healthy donors cross-react with tetanus toxoid. Eur J Immunol 29: 1139–1148CrossRefPubMedGoogle Scholar
  35. Juhlin L, Michaelsson G (1969) Cutaneous reactions to kallikrein, bradykinin and histamine in healthy subjects and in patients with urticaria. Acta Derm Venereol (Stockh) 49: 26–36PubMedGoogle Scholar
  36. Kanazawa K, Yaoita H, Tsuda F, Okamoto H. (1996) Hepatitis C virus infection in patients with urticaria. J Am Acad Dermatol 35: 195–198CrossRefPubMedGoogle Scholar
  37. Keahey TM, Greaves MW (1980) Cold urticaria: dissociation of cold-evoked histamine release and urticaria following cold challenge. Arch Dermatol 116: 174–177CrossRefPubMedGoogle Scholar
  38. Kermani F, Niimi N, Francis DM, Barr RM, Black AK, Greaves MW (1995) Characterisation of a novel mast cell-specific histamine-releasing activity in chronic idiopathic urticaria. J Invest Dermatol 105: 452Google Scholar
  39. Kikuchi Y, Kaplan AP (2001) Mechanisms of autoimmune activation of basophils in chronic urticaria. J Allergy Clin Immunol 107: 1056–1062CrossRefPubMedGoogle Scholar
  40. Kikuchi Y, Kaplan AP (2002) A role for C5a in augmenting IgG-dependent histamine release from basophils in chronic urticaria. J Allergy Clin Immunol 109: 114–118CrossRefPubMedGoogle Scholar
  41. Koro O, Dover JS, Francis DM, Black AK, Kelly RW, Barr RM, Greaves MW (1986) Release of prostaglandin D2 and histamine in a case of localised heat urticaria, and effect of treatment. Br J Dermatol 115: 721–728PubMedGoogle Scholar
  42. Lawlor F, Black AK, Milford Ward A, Morris R, Greaves MW (1989a) Delayed pressure urticaria: objective evaluation of a variable disease using a dermographometer and assessment of treatment using colchicine. Br J Dermatol 120: 403–408PubMedGoogle Scholar
  43. Lawlor F, Black AK, Breathnach AS, Greaves MW (1989b) Vibratory angioedema: lesion induction, clinical features, ultrastructural findings and response to therapy. Br J Dermatol 120: 93–99PubMedGoogle Scholar
  44. Lawrence CM, Jorizzo JL, Black AK, Coutts A, Greaves MW (1981) Cholinergic urticaria associated with angioedema. Br J Dermatol 105: 543–550PubMedGoogle Scholar
  45. Leznoff A, Josse RG, Denburg J, Dolovich J (1983) Association of chronic urticaria and angioedema with thyroid autoimmunity. Arch Dermatol 119: 636–640CrossRefPubMedGoogle Scholar
  46. Leznoff A, Sussman GL (1989) Syndrome of idiopathic chronic urticaria and angioedema with thyroid autoimmunity — a study of 90 patients. J Allergy Clin Immunol 84: 66–71PubMedGoogle Scholar
  47. Lowman MA, Rees PH, Benyon RC (1988) Human mast cell heterogeneity. Histamine release from mast cells dispersed from skin, lung, adenoids, tonsils and colon in response to IgE-dependent and non-immunological stimuli. J Allergy Clin Immunol 81: 590–597PubMedGoogle Scholar
  48. MacGlashan DW, Bochner BS, Adelman DC (1987) Down regulation of FcRI expression on human basophils during in vivo treatment of atopic human patients with anti-IgE antibody. J Immunol 158: 1438–1445Google Scholar
  49. May CD (1985) Are confusion and controversy about food hypersensitivity really necessary? J Allergy Clin Immunol 75: 329–333PubMedGoogle Scholar
  50. Misch K, Black AK, Greaves MW (1983) Almosauri T, Stanworth DR, Passive transfer of cold urticaria to monkeys. Acta Derm Venereol (Stockh) 63: 163–164PubMedGoogle Scholar
  51. Murphy GM, Black AK, Greaves MW (1983) Persisting cholinergic erythema — a variant of cholinergic urticaria. Br J Dermatol 109: 343–348PubMedGoogle Scholar
  52. Murphy GM, Zollman PE, Greaves MW, Winkelmann RK (1987) Symptomatic dermographism (factitious urticaria) — passive transfer experiments from human to monkey. Br J Dermatol 116: 801–804PubMedGoogle Scholar
  53. Niimi N, Francis DM, Kermani F, Black AK, Barr RM, Grattan CEH, Greaves MW (1996) Dermal mast cell activation by autoantibodies against the high affinity IgE receptor in chronic urticaria. J Invest Dermatol 106: 1001–1006CrossRefPubMedGoogle Scholar
  54. O’Donnell BF, Black AK (1995) Urticarial vasculitis. Int Angiol 14: 166–174PubMedGoogle Scholar
  55. O’Donell BF, Lawlor F, Simpson J, Morgan M, Greaves MW (1997) The impact of chronic urticaria on quality of life. Br J Dermatol 136: 197–201CrossRefPubMedGoogle Scholar
  56. O’Donnell BF, Barr RM, Black AK, Francis DM, Greaves MW (1998) Intravenous immunoglobulin in chronic autoimmune urticaria. Br J Dermatol 138: 101–6CrossRefPubMedGoogle Scholar
  57. O’Donnell BF, O’Neill CM, Francis DM, Niimi N, Barr RM, Barlow RJ, Greaves MW, Welsh K (1999) Human leucocyte antigen class II associations in chronic idiopathic urticaria. Br J Dermatol 140: 853–858CrossRefPubMedGoogle Scholar
  58. Ohnishi-Inoue Y, Mitsuya K, Horio T (1998) Aspirin-sensitive urticaria: provocation with a leukotriene receptor antagonist. Br J Dermatol 138: 483–485CrossRefPubMedGoogle Scholar
  59. Ozkaya-Bayazit E, Demir K, Ozgaroglu E, Kaymakoglu S, Ozamagar G (1998) Helicobacter pylori eradication in patients with chronic urticaria. Arch Dermatol 314: 1165–1166CrossRefGoogle Scholar
  60. Pachlopnik JM, Horn MP, Fux M, Dahinden M, Mandallaz M, Schneeberger D, Baldi L, Vogel M, Stadler BM, Miescher SM (2004) Natural anti-FcRI autoantibodies may interfere with diagnostic tests for autoimmune urticaria. J Autoimmun 22: 43–51CrossRefPubMedGoogle Scholar
  61. Pacor ML, Di Lorenzo G, Corrocher R. (2001) Efficacy of leukotriene receptor antagonist in chronic urticaria. A double-blind, placebo-controlled comparison of treatment with montelukast and cetirizine in patients with chronic urticaria with intolerance to food additive and/or acetylsalicylic acid. Clin Exp Allergy 31: 1607–1614CrossRefPubMedGoogle Scholar
  62. Pandey V, Mihara S, Fensome-Green A, Bolsover S, Cockcroft S (2004) Monomeric IgE stimulates NFAT translocation into the nucleus, a rise in cytosol Ca2+, degranulation, and membrane ruffling in the cultured rat basophilic leukemia-2H3 mast cell line. J Immunol 172: 4048–4058PubMedGoogle Scholar
  63. Pastorello EA (1995) Evaluating new tests for the diagnosis of food allergy. Allergy 50: 289–291PubMedGoogle Scholar
  64. Pirisi A (2000) Antihistamines impair driving as much as alcohol. Lancet 355: 905Google Scholar
  65. Ramsay CA (1977) Solar urticaria treatment by inducing tolerance to artificial radiation and natural light. Arch Dermatol 113: 1222–1225PubMedGoogle Scholar
  66. Reimers A, Pichler C, Helbling A, Pichler WJ, Yawalkar N (2002) Zafirlukast has no beneficial effects in the treatment of chronic urticaria. Clin Exp Allergy 32: 1763–1768PubMedGoogle Scholar
  67. Rivera J (2002) Molecular adapters in FcɛRI signaling and the allergic response. Curr Opin Immunol 14: 688–693CrossRefPubMedGoogle Scholar
  68. Rorsman H (1961) Basopenia in urticaria. Acta Allergol 16: 185–215PubMedGoogle Scholar
  69. Sabroe RA, Francis DM, Barr RM, Black AK, Greaves MW (1998) Anti-FcɛRI autoantibodies and basophil histamine release ability in chronic idiopathic urticaria. J Allergy Clin Immunol 102: 651–658PubMedGoogle Scholar
  70. Sabroe RA, Seed PT, Francis DM, Barr RM, Black AK, Greaves MW (1999a) Chronic idiopathic urticaria: comparison of clinical features of patients with or without anti-FcɛRI or anti-IgE autoantibodies. J Am Acad Dermatol 40: 443–450PubMedGoogle Scholar
  71. Sabroe RA, Poon E, Orchard GE, Lane D, Francis DM, Barr RM, Black AK, Greaves MW (1999b) Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: comparison of patients with and without anti-FcɛRIα or anti-IgE autoantibodies. J Allergy Clin Immunol 103: 484–493PubMedGoogle Scholar
  72. Sabroe RA, Grattan CEH, Francis DM, Black AK, Barr RM, Greaves MW (1999c) The autologous serum skin test: a screening test for autoantibodies in chronic idiopathic urticaria. Br J Dermatol 140: 446–452CrossRefPubMedGoogle Scholar
  73. Sabroe RA, Fiebiger E, Francis DM, Maurer D, Seed PT, Grattan CE, Black AK, Stingl G, Greaves MW, Barr RM (2002) Classification of anti-FcɛRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity. J Allergy Clin Immunol 110: 492–499CrossRefPubMedGoogle Scholar
  74. Schnyder B, Helbling A, Pichler WJ (1999) Chronic idiopathic urticaria: natural course and association with Helicobacter pylori infection. Int Arch Allergy Immunol 119: 60–63CrossRefPubMedGoogle Scholar
  75. Sibbald RG, Black AK, Eady RAJ, James M, Greaves MW (1981) Aquagenic Urticaria: evidence of a cholinergic and histaminergic basis. Br J Dermatol 105: 297–302PubMedGoogle Scholar
  76. Smith CH, Atkinson B, Morris RW, Hayes N, Foreman JC, Lee TH. (1992) Cutaneous responses to vasoactive intestinal polypeptide in chronic idiopathic urticaria. Lancet. 339:91–93CrossRefPubMedGoogle Scholar
  77. Tam SW, Demissie S, Thomas D, Daeron M (2004) A bispecific antibody against human IgE and human FcRII that inhibits antigen-induced histamine release by human mast cells and basophils. Allergy 59: 772–780PubMedGoogle Scholar
  78. Tong LJ, Balakrishnan G, Kochan JP, Kinet J-P, Kaplan AP (1997) Assessment of autoimmunity in chronic urticaria. J Allergy Clin Immunol 99: 461–465PubMedGoogle Scholar
  79. Wedi B, Wagner S, Werfil T, Mann MP, Kapp A (1998) Prevalence of Helicobacter pylori-associated gastritis in chronic urticaria. Int Arch Allergy Immunol 116: 288–294CrossRefPubMedGoogle Scholar
  80. Weiner HL (1997) Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol Today 18: 335–343PubMedGoogle Scholar
  81. Wolfrom E, Chene G, Boisseau H, Beylot C, Geniaux M, Taleb A (1995) Chronic urticaria and Toxocara canis. Lancet 345: 196CrossRefGoogle Scholar
  82. Ying S, Kikuchi Y, Meng Q, Kay AB, Kaplan AP (2002) TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reaction. J Allergy Clin Immunol 109:694–700CrossRefPubMedGoogle Scholar
  83. Zuberbier T, Bohm M, Czarnetski BM (1993) Food intake in combination with a rise in body temperature: a newly defined cause of angioedema. J Allergy Clin Immunol 91: 1226–1227CrossRefPubMedGoogle Scholar
  84. Zweiman B, Valenzano M, Atkins PC, Tanus T, Getsy JA (1996) Characteristics of histamine-releasing activity in sera of patients with chronic idiopathic urticaria. J Allergy Clin Immunol 98: 89–98PubMedGoogle Scholar
  85. Zuberbier T, Greaves MW, Juhlin L, Kobza-Black A, Maurer D, Stingl G, Henz BM (2001) Definition, classification, and routine diagnosis of urticaria: a consensus report. J Investig Dermatol Symp Proc. 6: 123–127CrossRefPubMedGoogle Scholar

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© Springer-Verlag Wien 2005

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  • Michihiro Hide
  • Malcolm W. Greaves

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