Clinical Estrogen Trials in Patients with Schizophrenia

  • Jayashri Kulkarni


Luteinizing Hormone Antipsychotic Drug Brief Psychiatric Rate Scale Luteinizing Hormone Level Estradiol Valerate 


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  1. Behrens S, Häfner H, De Vry J, Gattaz WF (1992) Estradiol attenuates dopamine-medicated behavior in rats. Implications for sex differences in schizophrenia. Schizophr Res 6: 114CrossRefGoogle Scholar
  2. Brambilla F, Penati G (1978) Perspectives in endocrine psychobiology. In: Brambilla F and Bridges P (ed). Perspectives in endocrine psychobiology. Witey, London, 309–422Google Scholar
  3. DiPaolo T, Payet P, Labrie F (1982) Effect of prolactin and estradiol on rat striated dopamine receptors. Life Sci 31: 2921–2929Google Scholar
  4. Ferretti C, Blengio M, Vigna I, Ghia P, Gerazzani E (1992) Effects of estradiol on the ontogenesis of striatial dopamine D1 and D2 receptor sites in male and female rats. Brain Res 571: 212–217PubMedCrossRefGoogle Scholar
  5. Fink G (1995) The psychoprotective action of estrogen is mediated by central serotonergic as well as dopaminergic mechanisms. In: Takada A and Curzon G (eds). Serotonin in the central nervous system and periphery. Elsevier Science, Amsterdam, 175–187Google Scholar
  6. Fink G, Sumner B, McQueen JK, Wilson H, Rose R (1998) Sex steriod control of mood, mental state and memory. Clin Exp Pharmacol Physiol 25: 764–765PubMedGoogle Scholar
  7. Fink G, Sumner B, Rosie R, Wilson H, McQueen J (1999) Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory. Behav Brain Res 105: 53–68PubMedCrossRefGoogle Scholar
  8. Gordon HH, Borison RL, Diamond BI (1980) Modulation of dopamine receptor sensitivity by estrogen. Biol Psychiatry 15: 389–396PubMedGoogle Scholar
  9. Gordon JH, Perry KO (1983) Pre-and postsynaptic neurochemical alteration following estrogen-induced striatal dopamine hypo-and hypersensitivity. Brain Res Bull 10: 425–428PubMedCrossRefGoogle Scholar
  10. Häfner H (1991) The epidemiology of beginning schizophrenia. Presented at the WPA Section of Epidemiology and Community Psychiatry Symposium, June 14–16, OsloGoogle Scholar
  11. Hoskins RG (1920) Endocrine factors in dementia praecox. N Engl J Med 200: 361Google Scholar
  12. Joyce JN, Smith RL, Van Hartesveldt C (1982) Estradiol suppresses then enhances intracaudate dopamine-induced contralateral deviation. Eur J Pharm 81: 117–122Google Scholar
  13. Kraepelin E (1982) Psychiatrie, vol 3, part 2, 8th ed. Translated (1919). Dementia praecox and paraphrenia. Livingstone, EdinburghGoogle Scholar
  14. Kulkarni J, de Castella A, Riedel A, Taffe J, Fitzgerald P, Burger H (2001) Estrogen — a potential new treatment in schizophrenia. Schizophr Res 48: 137–144PubMedCrossRefGoogle Scholar
  15. Kulkarni J, Smith D, McKenzie D, Hill C, Keks N, Singh B, Copolov D (1995) Donadotrophin response to naloxone challenge in female and male psychotic patients. Biol Psychiatry 38: 701–703PubMedCrossRefGoogle Scholar
  16. Kulkarni J, de Castella A, Smith D, Taffe J, Keks N, Copolov D (1996a) A clinical trial of the effects of estrogen in acutely psychotic women. Schizoph Res 20: 247–252CrossRefGoogle Scholar
  17. Kulkarni J, Gostt K, de Castella A (1996b) The menstrual cycle in women with schizophrenia. Schizophr Res 18: 254Google Scholar
  18. Mason JW (1975) Emotion as reflected in patterns of endocrine investigation. In: Levi L (ed) Emotions: their parameters and measurement. Raven Press, New York, 143–181Google Scholar
  19. Mosselman S, Polman J, Dukema R (1996) ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett 392: 49–53PubMedCrossRefGoogle Scholar
  20. Perry KO, Diamond BI, Fields JZ, Gordon JH (1981) Hypophysectomy induced hyper-sensitivity to dopamine: antagonism by estrogen. Brain Res 226: 211–219PubMedCrossRefGoogle Scholar
  21. Sachar EJ, Mason JW, Kolmer HS, Arfess KL(1963) Psychoendocrine aspects of acute schizophrenic reactions. Psychosom Med 25: 510PubMedGoogle Scholar
  22. Seeman MV, Lang M (1990) The role of estrogens in schizophrenia gender differences. Schizophr Bull 16: 185–195PubMedGoogle Scholar
  23. Shughrue PJ, Lane MV, Merchenthaler I (1997) Comparative distribution of estrogen receptor and X and B MRNA in the rat central nervous system. J Compr Neurol 388: 507–525Google Scholar
  24. Sumner BEH, Grant DE, Rosie R, Hegele-Hartung Ch, Fritzemeier KH, Fink G (1999) Effects of tamoxifen on serotonin transporter and 5-hydroxytryptamine 2A receptor binding sites and mRNA levels in the brain of ovariectomized rats with or without acute estradiol replacement. Mol Brain Res 73: 119–128PubMedCrossRefGoogle Scholar

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© Springer-Verlag/Wien 2005

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  • Jayashri Kulkarni

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