Impaired Insulin Processing in Human Insulinoma


Beta Cell Secretory Granule Hyperinsulinemic Hypoglycemia Sorting Receptor Immature Secretory Granule 
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  1. Cool DR, Normant E, Shen FS, Chen HC, Pannell L, Zhang Y, and Loh YP (1997) Carboxypeptidase E is a regulated secretory pathway sorting receptor: Genetic obliteration leads to endocrine disorders in Cpe(fat) mice. Cell 88: 73CrossRefPubMedGoogle Scholar
  2. Komminoth P, Heitz PU, and Roth J (1999) Human insulinoma: clinical, cellular, and molecular aspects. Endocr Pathol 10: 269PubMedGoogle Scholar
  3. Neerman-Arbez M, Sizonenko SV, and Halban P (1993) Slow cleavage at the proinsulin B-chain/connecting peptide junction associated with low levels of endoprotease PC1/3 in transformed β cells. J Biol Chem 268: 16098PubMedGoogle Scholar
  4. Roth J, Komminoth P, and Heitz PU (1995) Topographic abnormalities of proinsulin — insulin conversion in functioning human insulinomas: Comparison of immunoelectron microscopic and clinical data. Am J Pathol 147: 489PubMedGoogle Scholar
  5. Roth J, Komminoth P, Klöppel G, and Heitz PU (1995) Diabetes and endocrine pancreas. In: Anderson’s pathology (Damjanov I, and Linder J, eds). St. Louis Chicago: Mosby Year Book, pp 2042Google Scholar
  6. Smeekens S, Montag A, Gary T, Albiges-Rizo C, Carroll R, Benig M, Phillips L, Martin S, Ohagi S, Gardner P, et al (1992) Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3. Proc Natl Acad Sci USA 89: 8822PubMedGoogle Scholar
  7. Tooze S, Flatmark T, Tooze J, and Huttner WB (1991) Characterization of the immature secretory granule, an intermediate in granule biosynthesis. J Cell Biol 115: 1491CrossRefPubMedGoogle Scholar

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© Springer-Verlag/Wien 2005

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