Ubiquitination of Myc: Proteasomal Degradation and Beyond
The level of Myc proteins is a critical determinant of cellular proliferation and apoptosis. Ubiquitination of Myc plays a key role in controlling protein levels by stimulating proteasomal degradation of the protein. Some experiments suggest that ubiquitination may also regulate Myc function in addition to turnover. This review attempts to summarize current knowledge about this field.
KeywordsUbiquitin Ligase Polyubiquitin Chain Nontransformed Cell Tissue Culture Experiment Multiple Human Tumor
Work in the authors' laboratory on Myc turnover is funded by the Deutsche Forschungsgemeinschaft via the SFB593 (“Mechanisms of cellular compartmentalization and the relevance for disease”).
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