Transcriptional Control and the Ubiquitin–Proteasome System
Regulation of transcription is a critically important process that controls development, differentiation, and the maintenance of cellular homeostasis. Cells have evolved numerous mechanisms to keep gene transcription tightly in check, some of which involve the ubiquitin–proteasome system. In this chapter, we review evidence supporting the concept that ubiquitin and the proteasome not only control transcription, but provide the biochemical means to drive key steps in the transcription process forward.
KeywordsProteasome System Transcriptional Activation Domain License Model Potent Transcriptional Activator Proteasome Component
WPT was a Kimmel Foundation, and Leukemia and Lymphoma Society, Scholar. Work in the Tansey laboratory is supported by NIH Grant GM067728, the CSHL Cancer Center Support Grant CA45508, The Irving Hansen Memorial Foundation, and by US Public Health Service grant CA-13106 from the National Cancer Institute.
- vom Baur E, Zechel C, Heery D, Heine MJ, Garnier JM, Vivat V, Le Douarin B, Gronemeyer H, Chambon P, Losson R (1996) Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J 15:110–124PubMedGoogle Scholar