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Asymmetric Organocatalysis on a Technical Scale: Current Status and Future Challenges

  • H. Gröger
Conference paper
Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2007/2)

Introduction

The development of methodologies for the production of chiral building blocks is of crucial importance, as such enantiomerically pure molecules are required as key intermediates in the synthesis of drugs. Due to the increasing tendency to use enantiomerically pure molecules rather than racemates as chiral drugs, there is an increasing interest in developing efficient synthetic technologies. Among conceivable approaches such as multi-step syntheses starting from chiral pool molecules, resolution processes, and asymmetric catalytic technologies, the latter represents the most attractive access for most cases. During recent decades an increasing tendency in industry was observed to apply asymmetric catalytic processes (review: Blaser and Schmidt 2004). Supplementing the established catalytic technologies ‘Metal Catalysis’ (reviews: Katsuki 1999; Jacobsen and Wu 1999) and ‘Biocatalysis’ (review: Drauz and Waldmann 2002), recently a third technology type emerged with...

Keywords

Enantiomeric Excess Epoxidation Reaction High Enantioselectivities Cyclic Ketone Chiral Building Block 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

I am grateful for the support of many colleagues during the preparation of this contribution about large-scale organocatalysis. In this regard I would like to thank Dr. Dave Ager (DSM), Prof. Dr. Karlheinz Drauz, Dr. Ian Grayson (both Degussa AG), Dr. Charles Fehr (Firmenich), Prof. Dr. Eric Jacobsen (Harvard University), Prof. Dr. Jürgen Martens (University of Oldenburg), Prof. Dr. Kenji Maruoka (Kyoto University), Prof. Dr. Martin O'Donnell (University of Illinois), Prof. Dr. Yian Shi (Colorado State University), and Prof. Dr. Yoshiji Takemoto (Kyoto University) for personal communications. In addition, I would like to thank Prof. Dr. Albrecht Berkessel (University of Cologne), and Prof. Dr. Heribert Offermanns for many exciting discussions about asymmetric organocatalysis.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Department of Chemistry and PharmacyUniversity of Erlangen-NurembergErlangenGermany

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