Nucleophilic Carbenes as Organocatalysts

Conference paper
Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2007/2)


N-Heterocyclic carbenes (NHC) have become an important class of organocatalysts and class of ligands for transition-metal catalysis. In organocatalyzed umpolung reactions, thiazolium salt-derived NHC have been used successfully for decades. Even so, during recent years there has been an increased interest in NHC-catalyzed transformations and many new reactions have been developed. This article focuses on the use of NHC in the conjugate umpolung of α,β-unsaturated aldehydes.


Carbene Carbon Single Diastereomer Benzoin Condensation Azolium Salt Unfavorable Steric Interaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Generous financial support by the Deutsche Forschungsgemeinschaft (Priority program organocatalysis), the Fonds der Chemischen Industrie (Dozentenstipendium for F.G.), the Deutsche Akademische Austauschdienst (fellowship for K.H.) and the BASF AG (BASF Catalysis Award to F.G.) as well as donations by Bayer AG are gratefully acknowledged. In addition, the research of F.G. was also generously supported by the Alfried Krupp Prize for Young University Teachers of the Alfried Krupp von Bohlen und Halbach Foundation.


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Organisch Chemisches InstitutMünsterGermany

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