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Mammary Development, Carcinomas and Progesterone: Role of Wnt Signalling

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Progestins and the Mammary Gland

Part of the book series: Ernst Schering Foundation Symposium Proceedings ((SCHERING FOUND,volume 2007/1))

Abstract

The mammary gland begins development during embryogenesis but after exposure to hormonal changes during puberty and pregnancy undergoes extensive further development. Hormonal changes are key regulators in the cycles of proliferation, differentiation, apoptosis and remodelling associated with pregnancy, lactation and involution following weaning. These developmental processes within the breast epithelium can be explained by the presence of a long-lived population of tissue-specific stem cells. The longevity of these stem cells makes them susceptible to accumulating genetic change and consequent transformation. The ovarian steroid progesterone, acting via the secreted factor Wnt4, is known to be essential for side branching of the mammary gland. One function of Wnt proteins is self-renewal of adult tissue stem cells, suggesting that progesterone may exert its effects within the breast, at least partly, by regulating the mammary stem cell population.

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  1. R. Lamb, H. Harrison & R. B. Clarke

    Present address: Breast Biology Group, Cancer Studies, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX, Manchester, UK

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    O. Conneely C. Otto

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    Lamb, R., Harrison, H., Clarke, R.B. (2008). Mammary Development, Carcinomas and Progesterone: Role of Wnt Signalling. In: Conneely, O., Otto, C. (eds) Progestins and the Mammary Gland. Ernst Schering Foundation Symposium Proceedings, vol 2007/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/2789_2008_074

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