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PKC Isotype Functions in T Lymphocytes

  • G. Baier
Conference paper
Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2007/3)

Abstract

The main function of mature T cells is to recognize and respond to foreign antigens by a complex activation process involving differentiation of the resting cell to a proliferating lymphoblast actively secreting immunoregulatory lymphokines or displaying targeted cytotoxicity, ultimately leading to recruitment of other cell types and initiation of an effective immune response. In order to understand the physiology and pathophysiology of T lymphocytes, it is necessary to decode the biochemical processes that integrate signals from antigen, cytokine, integrin and death receptors. The principal upon which our work is based is to explore and identify gene products of distinct members of the AGC family of protein serine/threonine kinases as key players mediating cell growth regulation. Given the established important role of PKC θ as regulator of T cell fate and knowing that several other PKC isotypes are also expressed in T cells at a high level, we now summarize the physiological and non-redundant functions of PKC α, β, δ, , ζ and θ isotypes in T cells. This review describes the current knowledge of the physiological and non-redundant functions of the PKC gene products in T cells.

Keywords

Phorbol Ester Lung Inflammatory Response NFAT Activation Independent Scientific Group Pseudosubstrate Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AP-1

Activating protein-1

DAG

Diacylglycerol

EMSA

Electrophoretic mobility shift assay

ER

Endoplasmic reticulum

ERK

Extracellular signal-regulated kinase

FACS

Fluorescence-activated cell sorter

IκB

Inhibitor of κB

IKK

IκB kinase

IL2

Interleukin-2

IP3

Inositol-1,4,5-triphosphate

MAPK

Mitogen-activated protein kinase

MLR

Mixed lymphocyte reaction

NFAT

Nuclear factor of activated T cells

NFκB

Nuclear factor of κB

NO

Nitric oxide

PDB

Phorboldibutyrate

PDK

1 3-Phospoinositide dependent protein kinase-1

PIP2

Phospatidylinositol-4,5-biphosphate

PKC

Protein kinase C

PLC

Phospholipase C

PS

Phosphatidylserine

TCR

T cell receptor

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Medical University of InnsbruckInnsbruckAustria

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