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Breast Stem Cells and Cancer

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Cancer Stem Cells

Part of the book series: Springer Series on Biofilms ((SCHERING FOUND,volume 2006/5))

Abstract

Recent results have increased our understanding of normal stem cells and the signalling pathways which regulate them during the development of the mammary gland. Tumours in many tissues are now thought to develop from dysregulated stem cells and depend on activated stem cell self-renewal pathways such as Notch for their tumourigenic capacity. These cancer stem cells are recognised by specific cell surface proteins that they express and their capacity to grow tumours in vivo or spheres in vitro. We have described human breast DCIS mammospheres grown from cancer stem cells and demonstrated their dependence on the EGF and Notch receptor pathways. Stem cell self-renewal pathways such as these may represent novel therapeutic targets to prevent recurrence of pre-invasive and invasive breast cancer.

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Authors and Affiliations

  1. Breast Biology Group, School of Cancer and Imaging Sciences, Faculty of Medicine and Human Sciences, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK

    G. Farnie & R. B. Clarke

Authors
  1. G. Farnie
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  2. R. B. Clarke
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Correspondence to R. B. Clarke .

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O.D. Wiestler B. Haendler D. Mumberg

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© 2007 Springer-Verlag

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Farnie, G., Clarke, R.B. (2007). Breast Stem Cells and Cancer. In: Wiestler, O., Haendler, B., Mumberg, D. (eds) Cancer Stem Cells. Springer Series on Biofilms, vol 2006/5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/2789_2007_049

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  • DOI: https://doi.org/10.1007/2789_2007_049

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-70852-0

  • Online ISBN: 978-3-540-70853-7

  • eBook Packages: MedicineMedicine (R0)

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