T Cell Therapies
T cell therapies are increasingly used for the treatment of malignancies and viral-associated diseases. Initial studies focused on the use of unmanipulated T cell populations after allogeneic stem cell transplantation. More recently, the use of antigen-specific T cells has been explored. This chapter reviews the clinical experience with polyclonal Epstein-Barr virus (EBV)-specific cytotoxic T cells (CTL) for the treatment of EBV-associated malignancies. Strategies on how to improve the antitumor activity of EBV-specific CTL are being discussed. If effective, these strategies will have broad implications for T cell therapies for a range of human tumors with defined antigens.
KeywordsHematopoietic Stem Cell Transplantation Chimeric Antigen Receptor Adoptive Immunotherapy Donor Lymphocyte Infusion Hematopoietic Stem Cell Transplantation Recipient
The authors were supported by NIH grants PO1 CA94237 and the GCRC at Baylor College of Medicine (grant RR00188). S.G. is the recipient of a Doris Duke Clinical Scientist Development Award. H.E.H is the recipient of a Doris Duke Distinguished Clinical Scientist Award.
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