Nature's Choice of Genes Controlling Chronic Inflammation

  • R. Holmdahl
Conference paper
Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2006/4)


Inflammation is a physiological response that may go uncontrolled and thereby develop in a chronic way. This seems to happen in many common diseases of autoimmune, degenerative, or allergic character. Rheumatoid arthritis (RA) is by definition a chronic disease with an autoimmune inflammatory attack on diarthrodial cartilaginous joints. The development of new treatment neutralizing cytokines involved in the inflammatory attack has given relief and gives the promise of more effective treatment of already established disease. It is now time to set our eyes on a new vision to develop preventive and curative treatment based on knowledge of the unique and causative pathogenic mechanisms. To do this we believe it is important to identify the natural-selected polymorphisms that are associated with disease. These have proven to be extremely difficult to identify in complex diseases such as RA, but using animal models, this work is closer to reality. Animal models have recently been developed mimicking various aspects of the human disease. We will present an example in which a genetic polymorphism associated with the development of arthritis has been identified. On the basis of this finding, a new pathway involving control of immune tolerance by reactive oxidative species has been identified and a new class of antiinflammatory agents activating the induced oxidative burst protein complex is suggested.


Rheumatoid Arthritis Major Histocompatibility Complex Celiac Disease Major Histocompatibility Complex Class Oxidative Burst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



I am grateful for support from several foundations that have made this work possible: the Anna Greta Crafoord, King Gustaf V:s 80-year, the Swedish Science Research Council, the Strategic Research Foundation, and the EU project NeuroproMiSe—LSHM-CT-2005-018637 and LSHM-CT-2005-005223 (Euraps).


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Medical Inflammation ResearchLundSweden

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