An Integrated Approach to Developing Chemoenzymatic Processes at the Industrial Scale

Conference paper
Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2006/3)


Biocatalysis is becoming a transformational technology for chemical synthesis as a result of recent advances in enzyme discovery, structural biology, protein expression, high-throughput screening, and enzyme evolution technologies. To truly impact chemical synthesis at the industrial scale, biotransformations and chemical research and development must be integrated to develop cost-effective and environmentally friendly solutions for drug manufacture. In this chapter, some recent applications of chemoenzymatic synthesis of pharmaceutically active ingredients or advanced intermediates were selected to illustrate the principle of this integrated approach.


Candida Antarctica Lipase Substrate Modulation Enzymatic Resolution Excellent Enantioselectivity Site Saturation Mutagenesis 
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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.BioVerdant, Inc.San DiegoUSA

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