Isoindolones and Related N-Heterocycles Isoindolones and Related N-Heterocycles via Palladium Nanoparticle-Catalyzed 3-Component Cascade Reactions

  • R. Grigg
  • V. Sridharan
Conference paper
Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2006/3)


Non-phosphine-containing cyclopalladated N-heterocycles possessing either sp2 C–Pd(II) or sp3 C–Pd(II) bonds and simple Pd(II) salts are precursors of Pd(0) nanoparticles whose initial morphology is dependent on the nature of the precursor. Addition of polyvinylpyrrolidone (pvp) dramatically increases catalyst lifetime. Nanoparticle generation can be achieved at ambient temperature in the presence of carbon monoxide by a process akin to the water–gas shift reaction. Allene also lowers the temperature required for nanoparticle generation. 3-Component catalytic cascades employing one or both of these substrates provide access to a variety of 5- and 6-membered N-heterocycles including isoindolones, N-aminoisoindolones, phthalazones, dihydroisoquinolines, and isoquinolones.


Allyl Amine Heck Reaction Palladium Acetate Aryl Chloride Michael Acceptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank Johnson Matthey, Avecia, GlaxoSmithkline, the EPRSC, and Leeds University for support.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Chemistry DepartmentLeeds UniversityLeedsUK

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