Advertisement

Micro-Fluidic and Lab-on-a-Chip Technology

  • X. Zhang
  • S. J. Haswell
Conference paper
Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2006/3)

Abstract

By reducing the operational dimensions of a conventional macro-fluidic-based system down to the micron scale, one can not only reduce the sample volume, but also access a range of unique characteristics, which are not achievable in conventional macro-scale systems. This chapter will discuss the unique properties of miniaturised systems based on micro-fluidic and Lab-on-a-Chip technology and consider how these may influence the overall performance associated with chemical and biological processing. Some consideration will also be given to the selection of materials and/or surface modifications that will be proactive in exploiting the high surface area and thermal and mass transfer properties, to enhance process performance.

Keywords

Laminar Flow Condition Electrophoretic Velocity Mass Transfer Property Porous Monolith Analytical Flow Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Andersson H, van den Berg A (2004) Microfabrication and microfluidics for tissue engineering: state of the art and future opportunities. Lab Chip 4:98–103CrossRefGoogle Scholar
  2. Fick A (1855) Uber diffusion. Ann Phys Chem 94:59CrossRefGoogle Scholar
  3. Fletcher PDI, Haswell SJ, Pombo-Villar E, Warrington BH, Watts P, Wong SYF, Zhang X (2002a) Micro reactors: principles and applications in organic synthesis. Tetrahedron 58:4735CrossRefGoogle Scholar
  4. Fletcher PDI, Haswell SJ, Zhang X (2002b) Electrokinetic control of a chemical reaction in a lab-on-a-chip micro-reactor: measurement and quantitative modeling. Lab Chip 2:102CrossRefGoogle Scholar
  5. Fletcher PDI, Haswell SJ, Watts P, Zhang X (2004) Dekker encyclopedia of nanoscience and nanotechnology 2:1547Google Scholar
  6. Fritz JL, Owen MJ (1995) Hydrophobic recovery of plasma-treated polydimethylsiloxane. J Adhesives 54:33CrossRefGoogle Scholar
  7. Gillmor SD, Larson BJ, Braun JM, Mason CE, Cruz-Barba LE, Denes F, Lagally MG (2002) Low-contact-angle polydimethyl siloxane (PDMS) membranes for fabricating micro-bioarrays. Proceedings of the 2nd Annual IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, Madison WI, USA, p 51Google Scholar
  8. Haber C (2006) Microfluidics in commercial applications; an industry perspectiva. Lab Chip 6:1118–1821CrossRefGoogle Scholar
  9. Handique K, Burke DT, Mastrangelo CH, Burns MA (2000) Nanoliter liquid metering in microchannels using hydrophobic patterns. Anal Chem 72:4100–4109CrossRefGoogle Scholar
  10. Hau WLW, Trau DW, Sucher NJ, Wong M, Zohar Y (2003) Surface-chemistry technology for microfluidics. J Micromech Microeng 13:272CrossRefGoogle Scholar
  11. He P, Haswell SJ, Fletcher PDI (2004) Lab Chip 4:8CrossRefGoogle Scholar
  12. Hu SW, Ren X, Bachman M, Sims CE, Li GP, Allbritton NL (2002) Surface modification of poly(dimethylsiloxane) microfluidic devices by ultraviolet polymer grafting. Anal Chem 74:4117CrossRefGoogle Scholar
  13. Hunter RJ (1981) Zeta potential in colloid science. Academic Press, LondonGoogle Scholar
  14. Jensen KF (2001) Microreaction engineering: is small better? Chem Eng Sci 56:293CrossRefGoogle Scholar
  15. Lagally E, Mathies RA (2004) Integrated genetic analysis: microsystems. J Phy D Appl Phys 37:R245CrossRefGoogle Scholar
  16. Laurell T, Nilsson J, Jensen K, Harrison DJ, Kutter JP (eds) (2004) 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2004). Malmö, Sweden, September 26–30Google Scholar
  17. Manz A, Becker H (eds) (1998) Microsystem technology in chemistry and life sciences. Springer, Berlin Heidelberg New YorkGoogle Scholar
  18. Metaxas AC, Meredith RJ (1983) Industrial microwave heating. Peter Peregrinus, LondonGoogle Scholar
  19. Mills R (1973) Self-diffusion in normal and heavy water in the range 1–45°. J Phys Chem 77:685CrossRefGoogle Scholar
  20. Munson MS, Hasenbank MS, Fu E, Yager P (2004) Suppression of non-specific adsorption using sheath flow. Lab Chip 4:438–445CrossRefGoogle Scholar
  21. Munson MS, Hawkins KR, Hasenbank MS, Yager P (2005) Diffusion-based analysis in a sheath flow microchannel: the sheath flow T-sensor. Lab Chip 5:856–862CrossRefGoogle Scholar
  22. Nikbin N, Watts P (2004) Solid-supported continuous flow synthesis in microreactors using electroosmotic flow. Org Process Res Dev 8:942CrossRefGoogle Scholar
  23. Overbeek JTG (1952) Electro chemistry of double layer. In: Kruyt HR (ed) Colloid science, Vol. 1. Elsevier, AmsterdamGoogle Scholar
  24. Peterson DS, Rohr T, Svec FK, Frechet JMJ (2003) Dual-function microanalytical device by in situ photolithographic grafting of porous polymer monolith: integrating solid-phase extraction and enzymatic digestion for peptide mass mapping. Anal Chem 75:5328CrossRefGoogle Scholar
  25. Rice CL, Whitehead R (1965) Electrokinetic flow in a narrow cylindrical capillary. J Phys Chem 69:4017CrossRefGoogle Scholar
  26. Schneider TW, Schessler HM, Shaffer KM, Dumm JM, Younce LA (2001) Surface patterning and adhesion of neuroblastoma X glioma (NG108-15) cells. Biomed Microdev 3 4:315CrossRefGoogle Scholar
  27. Svec F (2004) Porous monoliths: emerging stationary phases for HPLC and related methods. LC GC Europe 18:17Google Scholar
  28. Takagi M, Maki T, Miyahara M, Mae K (2004) Production of titania nanoparticles by using a new microreactor assembled with same axle dual pipe. Chem Eng J 101:269CrossRefGoogle Scholar
  29. Takayama S, McDonald JC, Ostuni E, Liang MN, Kenis PJA, Ismagilov RF, Whitesides GM (1999) Patterning cells and their environments using multiple laminar fluid flows in capillary networks. Proc Natl Acad Sci USA 96:5545–5548CrossRefGoogle Scholar
  30. Whitesides GM (2006) The origins and the future of microfluidics. Nature 442:368–373CrossRefGoogle Scholar
  31. Yang YN, Li C Kameoka J, Lee KH, Craighead HG (2005) A polymeric microchip with integrated tips and in situ polymerized monolith for electrospray mass spectrometry. Lab Chip 5:869CrossRefGoogle Scholar
  32. Zhang X, Hayward DO (2006) Applications of microwave dielectric heating in environment-related heterogeneous gas-phase catalytic systems. Inorg Chim Acta 359:3421CrossRefGoogle Scholar
  33. Zhang X, Wiles C, Painter SL, Watts P, Haswell SJ (2006) Microreactors as tools for chemical research. Chim Oggi-Chem Today 24:43Google Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Department of ChemistryThe University of HullHullUK

Personalised recommendations