Functional Effects and Molecular Mechanisms of Subtype-Selective ERα and ERβ Agonists in the Cardiovascular System

  • P. A. Arias-Loza
  • V. Jazbutyte
  • K.-H. Fritzemeier
  • C. Hegele-Hartung
  • L. Neyses
  • G. Ertl
  • T. Pelzer
Conference paper
Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2006/1)


Gender differences in the development of cardiovascular disease suggested for a protective function of estrogens in heart disease. The negative or neutral outcome of clinical trials on hormone replacement therapy provides clear evidence that the role of female sex hormones in the cardiovascular system is more complex than previously thought. In particular, the function of estrogens can not be understood without detailed knowledge on the specific function of both estrogen receptor subtypes in the heart and in the vasculature. In here, we review recent studies on subtype selective ERα and ERβ agonists in different animal models of hypertension, cardiac hypertrophy and vascular inflammation. The results indicate that the activation of specific ER subtypes confers specific as well as redundant protective effects in hypertensive heart disease that might ultimately translate into novel treatment options for hypertensive heart disease.


Cardiac Hypertrophy Mineralocorticoid Receptor Hypertensive Heart Disease Mineralocorticoid Receptor Antagonist Perivascular Fibrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • P. A. Arias-Loza
    • 1
  • V. Jazbutyte
    • 1
  • K.-H. Fritzemeier
    • 2
  • C. Hegele-Hartung
    • 2
  • L. Neyses
    • 3
  • G. Ertl
    • 1
  • T. Pelzer
    • 1
  1. 1.Medizinische Klinik IUniversity of WürzburgWürzburgGermany
  2. 2.Gynecology and AndrologySchering AG, BerlinBerlinGermany
  3. 3.Division of CardiologyManchester Royal Infirmary, University of ManchesterManchesterUK

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