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Virus-Encoded G-Protein-Coupled Receptors: Constitutively Active (Dys)Regulators of Cell Function and Their Potential as Drug Target

  • H. F. Vischer
  • J. W. Hulshof
  • I. J. P. de Esch
  • M. J. Smit
  • R. Leurs
Conference paper
Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2006/2)

Abstract

G-protein-coupled receptors encoded by herpesviruses such as EBV, HCMV and KSHV are very interesting illustrations of the (patho)physiological importance of constitutive GPCR activity. These viral proteins are expressed on the cell surface of infected cells and often constitutively activate a variety of G-proteins. For some virus-encoded GPCRs, the constitutive activity has been shown to occur in vivo, i.e., in infected cells. In this paper, we will review the occurrence of virus-encoded GPCRs and describe their known signaling properties. Moreover, we will also review the efforts, directed towards the discovery of small molecule antagonist, that so far have been mainly focused on the HCMV-encoded GPCR US28. This virus-encoded receptor might be involved in cardiovascular diseases and cancer and seems an interesting target for drug intervention.

Keywords

Chemokine Receptor Inverse Agonist HCMV Infection Bicyclic Compound Constitutive Signaling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • H. F. Vischer
    • 1
  • J. W. Hulshof
    • 1
  • I. J. P. de Esch
    • 1
  • M. J. Smit
    • 1
  • R. Leurs
    • 1
  1. 1.Leiden/Amsterdam Center for Drug Research (LACDR), Division of Medicinal ChemistryFaculty of Sciences, Vrije Universiteit AmsterdamHV AmsterdamThe Netherlands

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