Designing Compound Libraries Targeting GPCRs
The design of compound libraries targeting GPCRs is of primary interest in pharmaceutical research because of their important role as signaling receptors and the herewith linked dominant place in the discovery portfolios. In the present symposium chapter, we outline GPCR compound library design strategies recently followed by our group and discuss them in a more general context.
KeywordsCompound Library Library Design Sequence Theme Bivalent Ligand Privileged Structure
Drs. R. Bouhelal, M. Gerspacher, and K. Seuwen (all NIBR associates) are acknowledged for various discussions. The text of this chapter is based in major parts of our previous publications.
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