Designing Compound Libraries Targeting GPCRs

  • E. Jacoby
Conference paper
Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2006/2)


The design of compound libraries targeting GPCRs is of primary interest in pharmaceutical research because of their important role as signaling receptors and the herewith linked dominant place in the discovery portfolios. In the present symposium chapter, we outline GPCR compound library design strategies recently followed by our group and discuss them in a more general context.


Compound Library Library Design Sequence Theme Bivalent Ligand Privileged Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Drs. R. Bouhelal, M. Gerspacher, and K. Seuwen (all NIBR associates) are acknowledged for various discussions. The text of this chapter is based in major parts of our previous publications.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Novartis Institutes for BioMedical ResearchDiscovery TehnologiesBaselSwitzerland

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