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G-Proteins and GPCRs: From the Beginning

  • H. R. Bourne
Conference paper
Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2006/2)

Abstract

From the point of view of a participant observer, I tell the discovery stories of trimeric G-proteins and GPCRs, beginning in the 1970s. As in most such stories, formidable obstacles, confusion, and mistakes make eventual triumphs even more exciting. Because these pivotally important signaling molecules were discovered before the recombinant DNA revolution, today's well-trained molecular biologist may find it amazing that we learned anything at all.

Keywords

Adenylyl Cyclase GTPase Activity Sodium Metabisulfite cAMP Synthesis Turkey Erythrocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

I thank Thomas Sakmar, Lutz Birnbaumer, Paul Insel, Zvi Selinger, and Elliott Ross for commenting on parts of the manuscript. Mistakes, however, are clearly my own.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.UCSFSan FranciscoUSA

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