G-Proteins and GPCRs: From the Beginning
From the point of view of a participant observer, I tell the discovery stories of trimeric G-proteins and GPCRs, beginning in the 1970s. As in most such stories, formidable obstacles, confusion, and mistakes make eventual triumphs even more exciting. Because these pivotally important signaling molecules were discovered before the recombinant DNA revolution, today's well-trained molecular biologist may find it amazing that we learned anything at all.
KeywordsAdenylyl Cyclase GTPase Activity Sodium Metabisulfite cAMP Synthesis Turkey Erythrocyte
I thank Thomas Sakmar, Lutz Birnbaumer, Paul Insel, Zvi Selinger, and Elliott Ross for commenting on parts of the manuscript. Mistakes, however, are clearly my own.
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