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Roles for Prestin in Harnessing the Basilar Membrane to the Organ of Corti

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Insights from Comparative Hearing Research

Part of the book series: Springer Handbook of Auditory Research ((SHAR,volume 49))

Abstract

This chapter is centered on the proposal that evolutionary changes in prestin provide the basis for the amplifying, impedance-matching, molecular link that harnesses the outer hair cells (OHCs) of the mammalian cochlea, via specialized supporting cells of the organ of Corti, to the enormous frequency range of the mechanically tuned basilar membrane. This devolution of frequency tuning from potential, intrinsic, frequency-tuning, mechanisms of the OHCs, themselves to an extrinsic source of frequency tuning has enabled mammals to listen to sounds over an enormous range of frequencies from infrasound to frequencies way beyond the auditory ranges of other amniotes. The final section of the chapter is concerned with the evidence that forces generated by prestin are under direct, inhibitory, centrifugal efferent neural control from the central nervous system.

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Acknowledgments

I thank my research collaborators, Andrei Lukashkin, Victoria, Lukashkina, Marcia Mellado, Thomas Weddell, and Jian Zou for stimulating discussion and George Burwood, Gareth Jones, and Thomas Weddell for comments on the manuscript. Research was supported by the Medical Research Council.

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  1. Hearing Research Group, School Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, BN2 4GJ, UK

    Ian Russell

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Correspondence to Ian Russell .

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  1. School of Medicine and Health Science, Carl von Ossietzky University, Oldenburg, Niedersachsen, Germany

    Christine Köppl

  2. School of Medicine and Health Science, Carl von Ossietzky University, Oldenburg, Niedersachsen, Germany

    Geoffrey A. Manley

  3. Department of Biology, University of Maryland, College Park, Maryland, USA

    Arthur N. Popper

  4. Falmouth, Massachusetts, USA

    Richard R. Fay

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Russell, I. (2013). Roles for Prestin in Harnessing the Basilar Membrane to the Organ of Corti. In: Köppl, C., Manley, G., Popper, A., Fay, R. (eds) Insights from Comparative Hearing Research. Springer Handbook of Auditory Research, vol 49. Springer, New York, NY. https://doi.org/10.1007/2506_2013_23

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