Abstract
Amyloidosis is a group of disorders with common histopathologic findings in which there is extracellular tissue deposition of fibrils composed of a variety of proteins. Clinical manifestations depend upon the type of precursor protein, the amount of amyloid deposition, and the tissue affected such as ocular structures, larynx, and tracheobronchial tree. Treatment may include targeted therapies, chemotherapy, surgery, and organ transplant.
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References
Aabo K, Walbom-Jorgensen S (1985) Spleen irradiation in chronic lymphocytic leukemia (CLL): palliation in patients unfit for splenectomy. Am J Hematol 19(2):177–180
Ali MS (1979) Treatment of pancreatic fistula by irradiation. Br J Clin Pract 33:148–149
Alth G, Koren H, Gasser G, Edler R (1985) On the therapy of indurated penis plastic by means of radium moulages. Strahlentherapie 161:30–34
Andersen PM, Grönberg H, Franzen L et al (2001) External radiation of the parotid glands significantly reduces drooling in patients with motor neurone disease with bulbar paresis. J Neurol Sci 191(1–2):111–114
Anselm K, Schuman BM (1972) Gastric irradiation for complicated peptic ulcer in geriatric patients. J Am Geriatr Soc 20:14–16
Aquino JA, Cunningham RM, Filbee JF (1967) Peyronie’s disease. J Urol 97:492–493
Ashworth A (1960) Peyronie’s disease. Proc R Soc Med 53:692–694
Assouline A, Levy A, Abdelnour-Mallet M et al (2014) Radiation therapy for hypersalivation: a prospective study in 50 amyotrophic lateral sclerosis patients. Int J Radiat Oncol Biol Phys 88(3):589–595
Beitler JJ, Vikram B, Silver CE et al (1995) Low-dose radiotherapy for multicystic benign lymphoepithelial lesions of the parotid gland in HIV-positive patients: long-term results. Head Neck 17(1):31–35
Bergink GJ, Deutman AF, van den Broek JFCM et al (1994) Radiation therapy for subfoveal choroidal neovascular membranes in age-related macular degeneration. A pilot study. Graefes Arch Clin Exp Ophthalmol 232:591–598
Bouabdallah R, Coso D, Gonzague-Casabianca L et al (2000) Safety and efficacy of splenic irradiation in the treatment of patients with idiopathic myelofibrosis: a report on 15 patients. Leuk Res 24(6):491–495
Bourry N, Guy N, Achard JL et al (2013) Salivary glands radiotherapy to reduce sialorrhea in amyotrophic lateral sclerosis: dose and energy. Cancer Radiother 17(3):191–195
Brand C, Arnoldussen M (2018) IRay therapy as an adjuvant therapy in newly diagnosed patients with neovascular age-related macular degeneration. Eye 32(8):1345–1352
Brown G, Wood IJ (1956) Treatment of chronic duodenal ulcer by antroduodenectomy and x-irradiation. Lancet 2:169–171
Brown G, Scott RK, Homan WP et al (1952) Antroduodenectomy and x-ray irradiation in the treatment of duodenal ulcer. Lancet 2:1145–1149
Brown CH, Sahba M, Levin E (1962) Irradiation with cobalt 60 teletherapy in the treatment of complicated peptic ulcer. Am J Gastroenterol 38:278–289
Bumpus HC (1924) Radium in the treatment of benign hypertrophy of the prostate. J Urol 12(1):63–70
Byhardt RW, Brace KC, Wiernik PH (1975) The role of splenic irradiation in chronic lymphocytic leukemia. Cancer 35(6):1621–1625
Bystrom J, Johansson B, Edsmyr F et al (1972) Induration penis plastica (Peyronie’s disease). Scand J Plast Reconstr Surg 6:1–5
Cankurtaran M, Oyan B, Kılıçkap S et al (2004) Idiopathic fibrosclerosis of bilateral orbits, bilateral ureters, thyroid: a case report and review of the literature. Int Urol Nephrol 36(4):495–498
Carr ZA, Kleinerman RA, Stovall M et al (2002) Malignant neoplasms after radiation therapy for peptic ulcer. Radiat Res 157(6):668–677
Carr ZA, Land CE, Kleinerman RA et al (2005) Coronary heart disease after radiotherapy for peptic ulcer disease. Int J Radiat Oncol Biol Phys 61(3):842–850
Carson CC III, Coughlin PW (1985) Radiation therapy for Peyronie’s disease: is there a place? J Urol 134:684–686
Chakravarthy V, Houston RF, Archer DB (1993) Treatment of age-related subfoveal neovascular membranes by teletherapy: a pilot study. Br J Ophthalmol 77:265–273
Char DH, LeBoit PE, Ljung B-M et al (1987) Radiation therapy for ocular necrobiotic xanthogranuloma. Arch Ophthalmol 105:174–175
Clayman CB, Palmer WL, Kirsner TB (1968) Gastric irradiation in the treatment of peptic ulcer. Gastroenterology 55:403–407
Cocco AE, Mendeloff AI (1970) Effects of gastric irradiation in duodenal ulcer patients: gastric secretory response to maximal histamine stimulation during a three year period. Johns Hopkins Med J 126:61–68
Cocco AE, Mendeloff AI (1979) Gastric irradiation of peptic ulcer. Am J Gastroenterol 71:577–581
Cook JC, Romano W (1962) Chronic lymphocytic leukemia and radiation therapy. Am J Roentgenol Radium Therapy Nucl Med 88:892–901
Cooper JN, Gelzayd EA, Kirshner JB (1968) Mild gastric fundal irradiation in the treatment of peptic esophagitis. Gastroenterol Endosc 14:222–224
Copperman TS, Truong MT, Berk JL et al (2019) External beam radiation for localized periocular amyloidosis: a case series. Orbit 38(3):210–216
Costleigh B, Keet J, Miyamoto C et al (1995) Prostate irradiation as an alternative to the conventional management of benign prostate hypertrophy. Radiat Oncol Investig 3:72–76
Cruz MD, Castilla PJL et al (2004) Laryngeal amyloidosis successfully treated with external radiotherapy. Case report. Rev del Inst Nac de Enfermedades Respir 17(3):198–203
Cuculich PS, Schill MR, Kashani R et al (2017) Noninvasive cardiac radiation for ablation of ventricular tachycardia. N Engl J Med 377(24):2325–2336
Cvek J, Knybel L, Neuwirth R (2019) 3256 Long-term safety of stereotactic body radiotherapy for ablation of ventricular tachycardia: a multicentric study. Eur Heart J 40(Suppl_1):ehz745-0048
Duggan HE (1964) Effect of x-ray therapy on patients with Peyronie’s disease. J Urol 91:572–573
Dunlop JA, Lathem JE (1969) X-ray therapy in Peyronie’s disease. South Med J 62:1485–1486
Eichorn RD, Wolever TH, Leite O (1961) New and expanded use of gastric irradiation therapy. South Med J 54:662–665
Elliott MA, Chen MG, Silverstein MN et al (1998) Splenic irradiation for symptomatic splenomegaly associated with myelofibrosis with myeloid metaplasia. Br J Haematol 103(2):505–511
Evans JR, Igwe C, Jackson TL et al (2020) Radiotherapy for neovascular age-related macular degeneration. Cochrane Database Syst Rev 8(8):CD004004
Feder BH (1971) Peyronie’s disease. J Am Geriatr Soc 19:947–955
Findlay JM, Newaishy GA, Sircus W et al (1974) Role of gastric irradiation in management of peptic ulceration and esophagitis. Br Med J 3:769–771
Finger PT, Berson A, Ng T et al (1999) Ophthalmic plaque radiotherapy for age-related macular degeneration associated with subretinal neovascularization. Am J Ophthalmol 127(2):170–177
Freire J, Longton WA, Miyamoto CT et al (1996) External radiotherapy in macular degeneration: technique and preliminary subjective response. Int J Radiat Oncol Biol Phys 36(4):857–860
Furlow WL, Swenson HE, Lee RE (1975) Peyronie’s disease: a study of its natural history and treatment with orthovoltage radiotherapy. J Urol 114:69–71
Gianni C, Rivera D, Burkhardt JD (2020) Stereotactic arrhythmia radioablation for refractory scar-related ventricular tachycardia. Heart Rhythm 17(8):1241–1248
Goldstein J, Rubin S, Silver C et al (1992) Radiation therapy as a treatment for benign lymphoepithelial parotid cysts in patients with human immunodeficiency virus. Int Radiat Oncol Biol Phys 23:1045–1050
Greenberger JS, Chaffey JT, Rosenthal DS et al (1977) Irradiation for control of hypersplenism and painful splenomegaly in myeloid metaplasia. Int J Radiat Oncol Biol Phys 2(11–12):1083–1090
Griem ML, Justman S, Weiss L (1984) The neoplastic potential of gastric irradiation. IV. Risk estimates. Am J Clin Oncol 7:675–677
Griem ML, Kleinerman RA, Boice JD et al (1994) Cancer following radiotherapy for peptic ulcer. J Natl Cancer Inst 86(11):842–849
Griff LC (1967) Peyronie’s disease. The role of radiation therapy and a general review. Am J Roentgenol Radium Ther Nucl 100:916–919
Guiney MJ, Liew KH, Quong GG et al (1989) A study of splenic irradiation in chronic lymphocytic leukemia. Int J Radiat Oncol Biol Phys 16(1):225–229
Guy N, Bourry N, Dallel R et al (2011) Comparison of radiotherapy types in the treatment of sialorrhea in amyotrophic lateral sclerosis. J Palliat Med 14(4):391–395
Harriman M, Morrison M, Hay J et al (2001) Use of radiotherapy for control of sialorrhea in patients with amyotrophic lateral sclerosis. J Otolaryngol Head Neck Surg 30(4):242
Hart PM, Chakravarthy U, Mackenzie G et al (2002) Visual outcomes in the subfoveal radiotherapy study: a randomized controlled trial of teletherapy for age-related macular degeneration. Arch Ophthalmol 120(8):1029–1038
Helvie WW, Ochsner SF (1972) Radiation therapy in Peyronie’s disease. South Med 65:1192–1196
Hermel M, Donner A, Remky A (2010) New treatment option for adult-onset limbal xanthogranuloma. Cornea 29(1):113–116
Hishikawa Y, Kamikonya N, Tanaka S, Mirira T (1986) Radiotherapy of pancreatic fistula. Radiat Med 4:27–28
Holman WP, Lewis RA (1941) Some observations on the effects of selective irradiation on the stomach in cases of chronic nonobstructive duodenal ulcer with hyperchlorhydria. Med J Aust 2:735
Incrocci L, Hop WC, Slob AK (2000) Current sexual functioning in 106 patients with Peyronie’s disease treated with radiotherapy 9 years earlier. Urology 56(6):1030–1033.
Ishibashi N, Maebayashi T, Aizawa T et al (2015) Myelosuppression toxicity of palliative splenic irradiation in myelofibrosis and malignant lymphoma. Hematology 20(4):203–207
Jackson TL, Chakravarthy U, Kaiser PK, et al for the INTREPID Study Group (2013) Stereotactic radiotherapy for neovascular age-related macular degeneration: 52-week safety and efficacy results of the INTREPID study. Ophthalmology 120(9):1893–1900
Jumeau R, Ozsahin M, Schwitter J (2018) Rescue procedure for an electrical storm using robotic non-invasive cardiac radio-ablation. Radiother Oncol 128(2):189–191
Kalra S, Utz J, Edell ES et al (2001) External-beam radiation therapy in the treatment of diffuse tracheobronchial amyloidosis. Mayo Clin Proc 76(8):853–856
Kasarskis EJ, Hodskins J, Clair WHS et al (2011) Unilateral parotid electron beam radiotherapy as palliative treatment for sialorrhea in amyotrophic lateral sclerosis. J Neurol Sci 308(1–2):155–157
Khaira M, Mutamba A, Meligonis G et al (2008) The use of radiotherapy for the treatment of localized orbital amyloidosis. Orbit 27(6):432–437
Kiefer ED, Smedal MI (1959) Therapeutic principles in management of peptic ulcer. Am J Dig Dis 4:1066–1072
Kishore AT, Chan C (1991) Resolution of pancreatic ascites after low dose radiation. South Med J 84:1364–1367
Klein JC, Berman NE (1961) Gastric radiation – non-surgical treatment for the surgical ulcer. JAMA 176:98–101
Koukourakis M, Zambatis H, Skarlatos J et al (1994) Transurethral radiotherapy for benign prostatic hypertrophy-related urethral obstruction Dosimetry, ethics, and preliminary results. Med Dosim 19(2):67–72
Kriz J, Micke O, Bruns F et al (2011) Radiotherapy of splenomegaly. Strahlenther Onkol 187(4):221
Kurrus JA, Hayes JK, Hoidal JR et al (1998) Radiation therapy for tracheobronchial amyloidosis. Chest 114(5):1489–1492
Lavrenkov K, Krepel-Volsky S, Levi I et al (2012) Low dose palliative radiotherapy for splenomegaly in hematologic disorders. Leuk Lymphoma 53(3):430–434
Levin E (1972) Peptic ulcer in the aged. Geriatrics 27:83–90
Lieber MR, Winans CS, Griem ML et al (1985) Sarcomas arising after radiotherapy for peptic ulcer disease. Dig Dis Sci 30:593–599
Liebman SD, Crocker AC, Geiser CF (1966) Corneal xanthomas in childhood. Arch Ophthalmol 76:221–229
Lloyd MS, Wight J, Schneider F (2020) Clinical experience of stereotactic body radiation for refractory ventricular tachycardia in advanced heart failure patients. Heart Rhythm 17(3):415–422
Loo BW Jr, Soltys SG, Wang L (2015) Stereotactic ablative radiotherapy for the treatment of refractory cardiac ventricular arrhythmia. Circ Arrhythm Electrophysiol 8(3):748–750
Marcus DM, Peskin E, et al for the AMDRT Research Group (2004) The age-related macular degeneration radiotherapy trial (AMDRT): one year results from a pilot study. Am J Ophthalmol 138(5):818–828
Martin CL (1972) Long time study of patients with Peyronie’s disease treated with irradiation. Am J Roentgenol Radium Ther Nucl Med 114:492–497
Mayinger M, Kovacs B, Tanadini-Lang S (2020) First magnetic resonance imaging-guided cardiac radioablation of sustained ventricular tachycardia. Radiother Oncol 152:203–207
McFarland JT, Kuzma C, Millard FE et al (2003) Palliative irradiation of the spleen. Am J Clin Oncol 26(2):178–183
McGeorge M (1950) Results of treatment of gastric hyperacidity by radium with special references to duodenal ulceration. Q J Med 19:111–128
Mira JG, Chabazian CM, del Regato JA (1980) The value of radiotherapy for Peyronie’s disease: presentation of 56 new case studies and review of the literature. Int J Radiat Oncol Biol Phys 6:1661–1666
Morris WR, Haik BG, Osborn FD et al (2000) Intraocular involvement in multifocal fibrosclerosis. Ophthalmology 107(5):962–966
Mourad WF, Hu KS, Shourbaji RA et al (2013a) Radiation therapy for benign lymphoepithelial cysts of parotid glands in HIV patients. Laryngoscope 123(5):1184–1189
Mourad WF, Young R, Kabarriti R et al (2013b) 25-year follow-up of HIV-positive patients with benign lymphoepithelial cysts of the parotid glands: a retrospective review. Anticancer Res 33(11):4927–4932
Nazmy MS, Radwan A, Mokhtar M (2008) Palliative spleen irradiation: can we standardize its technique? J Egypt Natl Canc Inst 20(1):31–35
Neben-Wittich MA, Foote RL et al (2007) External beam radiation therapy for tracheobronchial amyloidosis. Chest 132(1):262–267
Nelson RM, Jenson CB, Horsley BL et al (1968) Idiopathic retroperitoneal fibrosis producing distal esophageal obstruction. J Thorac Cardiovasc Surg 55:216–224
Neppelberg E, Haugen DF, Thorsen L et al (2007) Radiotherapy reduces sialorrhea in amyotrophic lateral sclerosis. Eur J Neurol 14(12):1373–1377
Neuwirth R, Cvek J, Knybel L (2019) Stereotactic radiosurgery for ablation of ventricular tachycardia. Europace 21(7):1088–1095
Niewald M, Wenzlawowicz KV, Fleckenstein J et al (2006) Results of radiotherapy for Peyronie’s disease. Int J Radiat Oncol Biol Phys 64(1):258–262
Oguz K, Kiratlı H, Oguz O et al (2002) Multifocal fibrosclerosis: a new case report and review of the literature. Eur Radiol 12(5):1134–1138
Olmos PR, Falko JM, Rea GL et al (1993) Fibrosing pseudotumor of the sella and parasellar area producing hypopituitarism and multiple cranial nerve palsies. Neurosurgery 32(6):1015–1021
Pacheco VA, Crespo EL, Zurita AJW et al (2015) External beam radiation therapy: a treatment modality in diffuse tracheobronchial amyloidosis. Arch Bronconeumol 51(11):607–608
Parmley VC, George DP, Fannin LA (1998) Juvenile xanthogranuloma of the iris in an adult. Arch Ophthalmol 116(3):377–379
Paulino AC, Reddy SP (1996) Splenic irradiation in the palliation of patients with lymphoproliferative and myeloproliferative disorders. Am J Hospice Palliat Med 13(6):32–35
Pecora JL, Sambursky JS, Vargha Z (1982) Radiation therapy in amyloidosis of the eyelid and conjunctiva: a case report. Ann Ophthalmol 14:194–196
Pietsch G, Anzeneder T, Bruckbauer H et al (2018) Superficial radiation therapy in Peyronie’s disease: an effective and well-tolerated therapy. Adv Radiat Oncol 3(4):548–551
Pistevou-Gombaki K, Zygogianni A, Kantzou I et al (2015) Splenic irradiation as palliative treatment for symptomatic splenomegaly due to secondary myelofibrosis: a multi-institutional experience. J BUON 20(4):1132–1136
Robinson CG, Samson PP, Moore KM (2019) Phase I/II trial of electrophysiology-guided noninvasive cardiac radioablation for ventricular tachycardia. Circulation 139(3):313–321
Rodrigues CI, Njo HJ, Karim AB (1995) Results of radiotherapy and vitamin E in the treatment of Peyronie’s disease. Int J Radiat Oncol Biol Phys 31:571–576
Roncadin M, Arcicasa M, Trovó MG et al (1987) Splenic irradiation in chronic lymphocytic leukemia. A 10-year experience at a single institution. Cancer 60(11):2624–2628
Schratter-Sehn AU, Cerveny M, Simmel H et al (2003) Short-time splenic irradiation for splenomegaly. Oncol Res Treat 26(1):21–24
Soldić Ž, Murgić J, Jazvić M et al (2011) Splenic irradiation in haematological malignancies and other haematological disorders–single institution experience. Acta Clin Croat 50(1):29–34
Teplitz R, Fox BW, Littman MS et al (1961) Intragastric beta irradiation with Ru-Rh106 in human subjects: results with single doses. J Nucl Med 2:187–199
Truong MT, Kachnic LA, Grillone GA et al (2012) Long-term results of conformal radiotherapy for progressive airway amyloidosis. Int J Radiat Oncol Biol Phys 83(2):734–739
Valmaggia C, Ries G, Ballinari P (2002) Radiotherapy for subfoveal choroidal neovascularization in age-related macular degeneration: a randomized clinical trial. Am J Ophthalmol 133(4):521–529
Viljoen IM, Goedhals L (1993) Peyronie’s disease-a perspective on the disease and the long-term results of radiotherapy. S Afr Med J 83:19–20
Wagner H Jr, McKeough PG, Desforges J et al (1986) Splenic irradiation in the treatment of patients with chronic myelogenous leukemia or myelofibrosis with myeloid metaplasia: results of daily and intermittent fractionation with and without concomitant hydroxyurea. Cancer 58(6):1204–1207
Weisser GW, Schmidt B, Hubener K-H et al (1987) Die Strahlenbehandlung der Induration penis plastica. Strahlenther Onkol 163:23–28
Weissler MC, Miller E, Fortune MA (1989) Sclerosing orbital pseudotumor: a unique clinical-pathologic entity. Ann Otol Rhinol Laryngol 98:496–501
Williams JL, Thomas GG (1970) The natural history of Peyronie’s disease. J Urol 103:75–76
Young HH (1917) The use of radium and the punch operation in desperate cases of enlarged prostate. Ann Surg 65(5):633
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Mathieu, D., Loo, B. (2023). Other. In: Roberge, D., Donaldson, S.S. (eds) Radiation Therapy of Benign Diseases. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2022_379
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