Abstract
Keloids and hypertrophic scars are pathological scars that arise from skin trauma such as acne, folliculitis, and piercing or surgical incisions (Betarbet and Blalock 2020). Keloids appear in about 10% of wounds and are more common in people with positive family history or dark skin phototypes (Guix et al. 2008). Beside the cosmetic impact, keloid can be responsible for pain, pruritis, or recurrent infections. The pathophysiology of keloid formation is poorly understood but thought to be related to overproduction of collagen fibers due to the activity of fibroblasts in the reticular dermis in response to overexpression of proinflammatory factors (Ogawa 2017).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bath-Hextall FJ, Matin RN, Wilkinson D, Leonardi-Bee J (2013) Interventions for cutaneous Bowen’s disease (review). Cochrane Database Syst Rev 2013(6):CD007281
Betarbet U, Blalock TW (2020) Keloids: a review of etiology, prevention, and treatment. J Clin Aesthet Dermatol 13:33–43
Blank A, Schnyder U (1985) Soft-X-Ray therapy in Bowen’s disease and erythroplasia of Queyrat. Dermatologica 171:89–94
Brown P (1966) Erythroplasia of Queyrat. Br J Plast Srug 19:378–382
Caccialanza M, Piccinno R, Beretta M, Gnecchi L (1999) Results and side effects of dermatologic radiotherapy: a retrospective study of irradiated cutaneous epithelial neoplasms. J Am Acad Dermatol 41:589–594
Caccialanza M, Piccinno R (2000) Radiotherapy of erythroplasia of Queyrat. Skin Cancer 15:201–206
Chung YL, Lee JD, Band D, Lee M (2000) Treatment of Bowen’s disease with specially designed radioactive skin patch. Eur J Nucl Med 27:842–846
Cox N, Dyson P (1995) Wound healing on the lower leg after radiotherapy or cryotherapy of Bowen’s disease and other malignant skin lesions. Br J Dermatol 133:60–65
Cox NH, Eedy DJ, Morton CA (2007) Guidelines for management of Bowen’s disease: 2006 update. Br J Dermatol 156:11–21
De Bearman R, Gourgerot H (1906) Cheloides des Maqueuses. Ann Dermatol Syphilol 7:151
Dupree MT, Kiteley RA, Weismantle K, Johnstone PA (2001) Radiation therapy for Bowen’s disease: lessons for lesions of the lower extremity. J Am Acad Dermatol 45:401–404
Emad M, Omidvari S, Dastgheib L, Ghaem H (2005) Surgical excision and immediate postoperative radiotherapy versus cryotherapy and intralesional steroids in the management of keloids: a prospective clinical trial. Med Princ Pract 19:402–405
Gandhi AK, Laviraj MA, Kashyap L, Rath GK (2014) Recurrent Bowen’s disease of scalp treated with high dose rate surface mold brachytherapy: a case report and review of literature. J Contemp Brachytherapy 6:389–394
Garg M, Weiss P, Sharma A, Beitler J (2004) Adjuvant high dose rate brachytherapy (Ir-192) in the management of keloids which have recurred after surgical excision and external radiation. Radiother Oncol 73:233–236
Graham J, Helwig E (1973) Erythroplasia of Queyrat: a clinicopathologic and histochemical study. Cancer 6:1396–1414
Guix B, Henriquez I, Andres A, Martinez A (2001) Treatment of keloids by high-dose-rate brachytherapy: a seven-year study. Int J Radiat Oncol Biol Phys 50:167–172
Guix B, Andres A, Salort P (2008) Keloid and hypertrophic scars. Springer
Herman JM, Pierce LJ, Sandler HM, Johnson TM (2008) Radiotherapy using a water bath in the treatment of Bowen’s disease of the digit. Radiother Oncol 88:398–402
Jiang P, Geenen M, Siebert F, Druecke D (2018) Efficacy and the toxicity of the interstitial high-dose-rate brachytherapy in the management of recurrent keloids: 5-year outcome. Brachytherapy 17:597–600
Kaplan C, Katoh A (1973) Erythroplasia of Queyrat (Bowen’s disease of the glans penis). J Surg Oncol 5:281–290
Kuribayashi S, Miyashita T, Azawa Y, Kumita S (2011) Post-keloidectomy irradiation using high-dose-rate superficial brachytherapy. J Radiat Res 52:365–368
Lee HJ, Jang YJ (2018) Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids. Int J Mol Sci 19(711):1–19
Mankowski P, Kanevsky J, Tomlinson J, Dyachenko A, Luc M (2017) Optimizing radiotherapy for keloids: a meta-analysis systematic review comparing recurrence rates between different radiation modalities. Ann Plast Surg 78:403–411
Mantell B, Morgan W (1969) Queyrat’s erythroplasia of the penis treated by beta particle irradiation. Br J Radiol 42:855–857
Mohandas P, Lowden M, Varma S (2020) Bowen’s disease. Br Med J 368:m813
Mustoe TA, Cooter RD, Gold MH, Ziegler UE (2002) International advisory panel on scar management: international clinical recommendations on scar management. Plast Reconstr Surg 110:560–571
Narakula G, Shenoy R (2008) A prospective clinical review of multi model approach for treating ear keloids. Indian J Plast Surg 41:2–7
Niessen FB, Spauwen PH, Schalkwijk J, Kon M (1999) On the nature of hypertrophic scars and keloids: a review. Plast Reconstr Surg 104:1435–1458
Ogawa R (2017) Keloids and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci 18(606):1–10
Ogawa R, Yoshitatsu S, Yoshida K, Miyashita T (2009) Is radiation therapy for keloids acceptable? The risk of radiation-induced carcinogenesis. Plast Reconstr Surg 124:1196–1201
Ogawa R, Tosa M, Dohi T, Kuribayashi S (2019) Surgical excision and postoperative radiotherapy for keloids. Scars Burn Heal 5:1–11
Ojeh N, Bharatha A, Gaur U, Forde AL (2020) Keloids: current and emerging therapies. Scars Burn Heal 6:1–18
Papillon J, Chassard JL (1992) Respective roles of radiotherapy and surgery in the management of epidermoid carcinoma of the anal margin. Dis Colon Rectum 35:422–429
Ragoowansi R, Cornes P, Moss A, Glees J (2003) Treatment of keloids by surgical excision and immediate postoperative single-fraction radiotherapy. Plast Reconstr Surg 111:1853–1859
Recalcati S, Caccialanza M, Piccinno R (2011) Postoperative radiotherapy for auricular keloids: a 26-year experience. J Dermatol Treat 22:38–42
Rio E, Bradet E, Peuvrel P, Dreno B (2009) Perioperative interstitial brachytherapy for recurrent keloid scars. Plast Reconstr Surg 124:180e
Speranza G, Sultanem K, Muanza T (2007) Descriptive study of patients receiving excision and radiotherapy for keloids. Int J Radiat Oncol Biol Phys 71:1465–1469
Van De Kar A, Kreulen M, Van Zuijlen P, Oldenburger F (2007) The results of surgical excision and adjuvant irradiation for therapy-resistant keloids: a prospective clinical outcome study. Plast Reconstr Surg 119:2248–2254
Vanderspek LL, Pond GR, Wells W, Tsang RW (2005) Radiation therapy for Bowen’s disease of the skin. Int J Radiat Oncol Biol Phys 63:505–510
Veen RE, Kal HB (2007) Postoperative high dose rate brachytherapy in the prevention of keloids. Int J Radiat Oncol Biol Phys 69:1205–1208
Viani G, Stefano E, Afonso S, De Fendi L (2009) Postoperative Strontium-90 brachytherapy in the prevention of keloids: results and prognostic factors. Int J Radiat Oncol Biol Phys 73:1510–1516
Vila Capel A, Vilar Palop J, Pedro Olive A, Fernandez A (2013) Adjuvance in refractory keloids using electron beam with a spoiler: recent result. Rep Pract Oncol Radiother 20:43–49
Wagner W, Alfrink M, Micke O, Willich N (2000) Results of prophylactic irradiation in patients with resected keloids: a retrospective analysis. Acta Oncol 39:217–220
Yamawaki S, Naitoh M, Ishiko T, Suzuki S (2011) Keloids can be forced into remission with surgical excision and radiation followed by adjuvant therapy. Reconstr Surg 67:402–406
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Sultanem, K. (2023). Dermatologic Conditions. In: Roberge, D., Donaldson, S.S. (eds) Radiation Therapy of Benign Diseases. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2022_371
Download citation
DOI: https://doi.org/10.1007/174_2022_371
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-35516-5
Online ISBN: 978-3-031-35517-2
eBook Packages: MedicineMedicine (R0)