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Autoimmune Disorders

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Radiation Therapy of Benign Diseases

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

In select cases, external beam radiation to the retrobulbar tissues and eye muscles produces reduction of signs and symptoms associated with autoimmune eye disease. Doses used commonly are 20 Gy in 10 fractions of 200 cGy calculated to the midplane for bilateral cases. Soft tissue findings, corneal involvement, and visual acuity impairment are most likely to respond well, although improved ocular mobility and reduction in proptosis may occur in >50% of cases. Treatment, whether unilateral or bilateral, requires simulation, treatment planning, dose calculation, and care in not exceeding tolerance levels. Treatment with IMRT is also now an option. Complications from correctly administered radiation therapy are rare, although cases of radiation retinopathy have been reported when large daily fraction sizes were inadvertently administered. Cases should be selected with care, with consultation with ophthalmologists and endocrinologists, as all patients with thyroid eye disease are not candidates for radiotherapy. The implementation of secondary therapeutics has increased the number of therapeutic options, but radiotherapy is still prescribed in moderate-to-severe Graves’ orbitopathy especially if IV corticosteroids are contraindicated or ineffective. The role of radiation continues to be the object of prospective clinical investigation (NCT02339142, NCT03098225).

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References

  • Appelqvist P, Salmo M, Rissanen P (1990) Radiotherapy in emergency treatment of malignant exophthalmos. Strahlenther Onkol 166(3):190–193

    Google Scholar 

  • Arakawa A et al (1990) Radiation therapy of invasive thymoma. Int J Radiat Oncol Biol Phys 18:529–534

    Google Scholar 

  • Beierwaltes WH (1953) X-ray treatment of malignant exophthalmos: a report on 28 patients. J Clin Endocrinol Metab 13(9):1090–1100

    Google Scholar 

  • Ben-Chetrit E (1986. ISSN 0003-4819) Total lymphoid irradiation in refractory systemic lupus erythematosus. Ann Intern Med 105(1):58. https://doi.org/10.7326/0003-4819-105-1-58

    Article  Google Scholar 

  • Besarab A et al (1982. ISSN 1660-8151) Adverse effects of prophylactic irradiation and acute tubular necrosis on renal graft function and survival. Nephron 31(4):347–353. https://doi.org/10.1159/000182679

    Article  Google Scholar 

  • Blahut RJ, Beierwaltes WH, Lampe I (1963) Exophthalmos response during Roentgen therapy. Am J Roentgenol Radium Ther Nucl Med 90:261–268

    Google Scholar 

  • Blizzard RM, Hung W, Chandler RW, Aceto T, Kyle M, Winship T (1962) Hashimoto’s thyroiditis. N Engl J Med 267:1015–1020

    Google Scholar 

  • Brennan MW, Leone CR, Janaki L (1983) Radiation therapy for Graves’ disease. Am J Ophthalmol 96(2):195–199

    Google Scholar 

  • Chen HHW et al (1996) Experience of radiotherapy in lethal midline granuloma with special emphasis on centrofacial T-cell lymphoma: a retrospective analysis covering a 34-year period. Radiother Oncol 38(1):1–6

    Google Scholar 

  • Choi JH, Lee JK (2020) Efficacy of orbital radiotherapy in moderate-to-severe active Graves’ orbitopathy including long-lasting disease: a retrospective analysis. Radiat Oncol 15(1):220

    Google Scholar 

  • Cook S et al (1986. ISSN 0140-6736) Effect of total lymphoid irradiation in chronic progressive multiple sclerosis. Lancet 327(8495):1405–1409. https://doi.org/10.1016/s0140-6736(86)91554-0

    Article  Google Scholar 

  • Cook SD et al (1987. ISSN 0364-5134) Total lymphoid irradiation in multiple sclerosis: blood lymphocytes and clinical course. Ann Neurol 22(5):634–638. https://doi.org/10.1002/ana.410220513

    Article  Google Scholar 

  • Covington EE, Lobes L, Sudarsanam A (1977) Radiation therapy for exophthalmos: report of seven cases. Radiology 122(3):797–799

    Google Scholar 

  • Crile G, Schneider RW (1952) Diagnosis and treatment of thyroiditis with special reference to the use of cortisone and ACTH. Cleve Clin Q 19:219–224

    Google Scholar 

  • Currier RD, Routh A, Hickman BT, Douglas MA (1983) Thymus irradiation for myasthenia gravis. Radiology 146:199–201

    Google Scholar 

  • DeRemee RA, Weiland LH, McDonald TJ (1980) Respiratory vasculitis. Mayo Clin Proc 55(8):492–498

    Google Scholar 

  • Desevilla E, Forrest JV, Zivnuska FR, Sagel SS (1975) Metastatic thymoma with myasthenia gravis and pure red cell aplasia. Cancer 36:1154–1157

    Google Scholar 

  • Devereux CK et al (1988. ISSN 0360-3016) Total lymphoid irradiation for multiple sclerosis. Int J Radiat Oncol Biol Phys 14(1):197–203. https://doi.org/10.1016/0360-3016(88)90068-5

    Article  Google Scholar 

  • Donaldson SS, Bagshaw MA, Kriss JP (1973) Supervoltage orbital radiotherapy for Graves’ ophthalmopathy. J Clin Endocrinol Metabol 37(2):276–285

    Google Scholar 

  • Drenguis B et al (1977. ISSN 0567-8064) Effect of local irradiation on the acute rejection process in transplanted kidneys. Acta Radiol Ther Phys Biol 16(3):241–244. https://doi.org/10.3109/02841867709133943

    Article  Google Scholar 

  • Durelli L et al (1993) Total body irradiation for myasthenia gravis: a long-term follow-up. Neurology 43:2215–2221

    Google Scholar 

  • Ellis M (1955) Malignant granuloma of the nose. Br Med J 1(4924):1251–1253

    Google Scholar 

  • Engel WK, Lichter AS, Dalakas MC (1981) Splenic and total-body irradiation treatment of myasthenia gravis. Ann N Y Acad Sci 377:744–754

    Google Scholar 

  • Fallahzadeh MK et al (2014) Local graft irradiation for kidney allograft rejection: a case series and review of the literature. Nephrourol Mon 6(3):E16262. ISSN 2251-7006. https://www.ncbi.nlm.nih.gov/pubmed/25032135

    MathSciNet  Google Scholar 

  • Fauci AS (1976) Radiation therapy of midline granuloma. Ann Intern Med 84(2):140

    Google Scholar 

  • Feder BH, Shramek JH, Ikeda TS (1963) Large-field radiotherapy in lethal midline granuloma. Radiology 81(2):293–299

    Google Scholar 

  • Friedmann I (1964) Midline granuloma. Proc R Soc Med 57(4):289–297

    Google Scholar 

  • Friedmann PI (1971) The changing pattern of granulomas of the upper respiratory tract. J Laryngol Otol 85(7):631–682

    Google Scholar 

  • Furr WE, Crile G (1954) Struma lymphomatosa: clinical manifestations and response to therapy. J Clin Endocrinol Metab 14:79

    Google Scholar 

  • Gedda PO, Lindgren M (1954) Pituitary and orbital Roentgen therapy in the hyperophthalmopathic type of Graves’ disease. Acta Radiol 3:211–220

    Google Scholar 

  • Ghadjar P et al (2010) Tailored total lymphoid irradiation in heart transplant patients: 10-years experience of one center. Radiat Oncol 5:3. ISSN 1748-717x. https://www.ncbi.nlm.nih.gov/pubmed/20078889

    Google Scholar 

  • Glass EJG (1955) Malignant granuloma. J Laryngol Otol 69(5):315–320

    Google Scholar 

  • Godfrey AM, Salaman JR (1977) Is graft irradiation of value in renal transplant rejection? Transplant Proc 9(1):1005–1006

    Google Scholar 

  • Goldman AJ, Herrmann C, Keesey JC, Mulder DG, Brown WJ (1975) Myasthenia gravis and invasive thymoma: a 20-year experience. Neurology 25:1021

    Google Scholar 

  • Gorman CA et al (2001) A prospective, randomized, double-blind, placebo-controlled study of orbital radiotherapy for Graves’ ophthalmopathy. Ophthalmology 108(9):1523–1534

    Google Scholar 

  • Hahn E et al (2014) Orbital radiation therapy for Graves’ ophthalmopathy: measuring clinical efficacy and impact. Pract Radiat Oncol 4(4):233–239

    Google Scholar 

  • Halperin EC et al (1982) Radiotherapy of polymorphic reticulosis. Br J Radiol 55(657):645–649

    Google Scholar 

  • Halperin EC et al (1984. ISSN 0360-3016) The use of local allograft irradiation following renal transplantation. Int J Radiat Oncol Biol Phys 10(7):987–990. https://doi.org/10.1016/0360-3016(84)90168-8

    Article  MathSciNet  Google Scholar 

  • Hamburger J et al (1962. ISSN 0002-9343) Renal homotransplantation in man after radiation of the recipient. Am J Med 32(6):854–871. https://doi.org/10.1016/0002-9343(62)90032-3

    Article  Google Scholar 

  • Hamburger J, Crosnier J, Dormont J (1965. ISSN 0140-6736) Experience with 45 renal homotransplantations in man. Lancet 285(7393):985–992. https://doi.org/10.1016/S0140-6736(65)91218-3

    Article  Google Scholar 

  • Harrison DF (1974) Non-healing granulomata of the upper respiratory tract. Br Med J 4(5938):205–209

    Google Scholar 

  • Heimann P (1970) Treatment of thyroiditis. Acta Med Scand 187:323–329

    Google Scholar 

  • Hume DM, Wolf JS (1967) Abrogation of the immune response: irradiation therapy and lymphocyte depletion. Modification of renal homograft rejection by irradiation. Transplantation 5:1174–1191

    Google Scholar 

  • Hume DM et al (1963) Renal homotransplantation in man in modified recipients. Ann Surg 158(4):608–644. ISSN 0003-4932. https://pubmed.ncbi.nlm.nih.gov/14067508. https://www.ncbi.nlm.nih.gov/pmc/articles/pmc1408453/

    Google Scholar 

  • Hurbli T et al (1985) Radiation therapy for thyroid eye diseases. Am J Ophthalmol 99(6):633–637

    Google Scholar 

  • Jones A (1951) Orbital x-ray therapy of progressive exophthalmos. Br J Radiol 24(288):637–646

    Google Scholar 

  • Kahaly G et al (1989) Treatment of Graves’ orbitopathy and its results. Dev Ophthalmol 20:109–126

    Google Scholar 

  • Kao SCS (1993) Radiotherapy in the management of thyroid orbitopathy. Arch Ophthalmol 111(6):819

    Google Scholar 

  • Kassel SH, Echevarria RA, Guzzo FP (1969) Midline malignant reticulosis (so-called lethal midline granuloma). Cancer 23(4):920–935

    Google Scholar 

  • Kazim M, Trokel S, Moore S (1991) Treatment of acute graves orbitopathy. Ophthalmology 98(9):1443–1448

    Google Scholar 

  • Kian Ang K et al (1985. ISSN 0167-8140) Kidney allograft tolerance in diabetic patients after total lymphoid irradiation (TLI). Radiother Oncol 3(3):193–199. https://doi.org/10.1016/S0167-8140(85)80028-1

    Article  Google Scholar 

  • Kinyoun JL et al (1984) Radiation retinopathy after orbital irradiation for Graves’ ophthalmopathy. Arch Ophthalmol 102(10):1473–1476

    Google Scholar 

  • Kolar OJ, Hornback NB (1986. ISSN 0140-6736) Total lymphoid irradiation in multiple sclerosis. Lancet 328(8504):453. https://doi.org/10.1016/s0140-6736(86)92151-3

    Article  Google Scholar 

  • Kreel I, Osserman KE, Genkins G, Kark AE (1967) Role of thymectomy in the management of myasthenia gravis. Ann Surg 165:111–117

    Google Scholar 

  • Lee CM, Lee JD, Hobson-Webb LD, Bedlack RS, Salama JK (2016) Treatment of thymoma-associated myasthenia gravis with stereotactic body radiotherapy: a case report. Ann Intern Med 165:300–301

    Google Scholar 

  • Levin B et al (1985. ISSN 0140-6736) Treatment of cadaveric renal transplant recipients with total lymphoid irradiation, antithymocyte globulin, and low-dose prednisone. Lancet 326(8468):1321–1325. https://doi.org/10.1016/S0140-6736(85)92624-8

    Article  Google Scholar 

  • Li YJ et al (2017) Clinical outcomes of Graves’ ophthalmopathy treated with intensity modulated radiation therapy. Radiat Oncol 12(1):171

    Google Scholar 

  • Lim TS et al (2007) Short-course total lymphoid irradiation for refractory cardiac transplantation rejection. J Heart Lung Transplant 26(12):1249–1254. ISSN 1557-3117. https://www.ncbi.nlm.nih.gov/pubmed/18096475

    Google Scholar 

  • Lindem MC, Clark JH (1969) Indications for survey in thyroiditis. Am J Surg 118:829–831

    Google Scholar 

  • Lindsay S, Dailey ME (1954) Granulomatous or giant cell thyroiditis. A clinical and pathologic study of thirty seven patients. Surg Gynecol Obstet 98:197–212

    Google Scholar 

  • Lloyd WC, Leone CR (1992) Supervoltage orbital radiotherapy in 36 cases of Graves’ disease. Am J Ophthalmol 113(4):374–380

    Google Scholar 

  • Lu C-F, Yu L, Jing Y, Zhang Y-F, Ke J (2018) Value of adjuvant radiotherapy for thymoma with myasthenia gravis after extended thymectomy. Chin Med J (Engl) 131(8):927–932

    Google Scholar 

  • Madden BP et al (1999) Intermediate term results of total lymphoid irradiation for the treatment of non-specific graft dysfunction after heart transplantation. Eur J Cardiothorac Surg 15(5):663–666. ISSN 1010-7940. https://www.ncbi.nlm.nih.gov/pubmed/10386414

    Google Scholar 

  • Marcocci C et al (1987) Orbital cobalt irradiation combined with retrobulbar or systemic corticosteroids for Graves’ ophthalmopathy: a comparative study. Clin Endocrinol (Oxf) 27(1):33–42

    Google Scholar 

  • Marcocci C et al (2003) Long-term safety of orbital radiotherapy for Graves’ ophthalmopathy. J Clin Endocrinol Metab 88(8):3561–3566

    Google Scholar 

  • Marsot-Dupuch K et al (1992) Lethal midline granuloma: impact of imaging studies on the investigation and management of destructive mid facial disease in 13 patients. Neuroradiology 34(2):155–161

    Google Scholar 

  • Matthiesen C et al (2012) The efficacy of radiation therapy in the treatment of Graves’ orbitopathy. Int J Radiat Oncol Biol Phys 82(1):117–123

    Google Scholar 

  • Merrill MD (1961) Roentgen therapy in Wegener’s granulomatosis; a case report. Am J Roentgenol Radium Ther Nucl Med 85:96–98

    Google Scholar 

  • Miller ML, Goldberg SH, Bullock JD (1991) Radiation retinopathy after standard radiotherapy for thyroid-related ophthalmopathy. Am J Ophthalmol 112(5):600–601

    Google Scholar 

  • Morgan RL (1964. ISSN 0009-9260) Clinical experience of whole-body radiation in man as a preliminary to renal transplantation. Clin Radiol 15(1):35–40. https://doi.org/10.1016/S0009-9260(64)80049-0

    Article  Google Scholar 

  • Mourits MP et al (2000) Radiotherapy for Graves’ orbitopathy: randomised placebo-controlled study. Lancet 355(9214):1505–1509

    Google Scholar 

  • Muniain MA, Moreno JC, Gonzalez Campora R (1986) Wegener’s granulomatosis in two sisters. Ann Rheum Dis 45(5):417–421

    Google Scholar 

  • Murray JPC (1958) The effect of prednisone on Hashimoto’s thyroiditis. Scott Med J 3:341–345

    Google Scholar 

  • Murray JE et al (1962) Kidney transplantation in modified recipients. Ann Surg 156(3):337–355. ISSN 0003-4932. https://pubmed.ncbi.nlm.nih.gov/14477464. https://www.ncbi.nlm.nih.gov/pmc/articles/pmc1466189/

    Google Scholar 

  • Najarian JS et al (1982) Fractionated total lymphoid irradiation as preparative immunosuppression in high risk renal transplantation: clinical and immunological studies. Ann Surg 196(4):442–452. ISSN 0003-4932. https://pubmed.ncbi.nlm.nih.gov/6812511. https://www.ncbi.nlm.nih.gov/pmc/articles/pmc1352705/

    Google Scholar 

  • Nakajima N et al (1977) Effects of intravenous bolus dosages of methylprednisolone and local radiation on renal allograft rejection and patient mortality. Surg Gynecol Obstet 144(1):63–66

    Google Scholar 

  • Neviani CB et al (2002) Radiation therapy as an option for upper airway obstruction due to Wegener’s granulomatosis. Otolaryngol Head Neck Surg 126(2):195–196

    Google Scholar 

  • Olivotto IA et al (1985) Supervoltage radiotherapy for Graves’ ophthalmopathy: CCABC technique and results. Int J Radiat Oncol Biol Phys 11(12):2085–2090

    Google Scholar 

  • Palmer D et al (1987) Radiation therapy for Graves’ ophthalmopathy: a retrospective analysis. Int J Radiat Oncol Biol Phys 13(12):1815–1820

    Google Scholar 

  • Papapetrov PD, Lazarus JH, MacSween RNM, Harden R (1972) Long-term treatment of Hashimoto’s thyroiditis with thyroxine. Lancet 2:1045–1048

    Google Scholar 

  • Parker RG (1988) Radiation retinopathy. JAMA 259(1):43

    Google Scholar 

  • Peeples WJ et al (1982. ISSN 0038-4348) Radiation therapy for renal transplant rejection reactions. South Med J 75(1):30–32. https://doi.org/10.1097/00007611-198201000-00009

    Article  Google Scholar 

  • Petersen IA et al (1990) Prognostic factors in the radiotherapy of Graves’ ophthalmopathy. Int J Radiat Oncol Biol Phys 19(2):259–264

    Google Scholar 

  • Phillips TL, Buschke F (1967) The role of radiation therapy in myasthenia gravis. Calif Med 106:282

    Google Scholar 

  • Pilepich MV et al (1983. ISSN 0041-1337) Renal graft irradiation in acute rejection. Transplantation 35(3):208–210. https://doi.org/10.1097/00007890-198303000-00004

    Article  Google Scholar 

  • Polico C et al (1986) Steward’s midline granuloma. Tumori 72(4):447–449

    Google Scholar 

  • Poorter RL et al (2007) Re-irradiation of a second localization of idiopathic midline destructive disease in the head and neck area. Eur Arch Otorhinolaryngol 264(12):1521–1523

    Google Scholar 

  • Prummel MF et al (1993) Randomised double-blind trial of prednisone versus radiotherapy in Graves’ ophthalmopathy. Lancet 342(8877):949–954

    Google Scholar 

  • Prummel MF et al (2004) A randomized controlled trial of orbital radiotherapy versus sham irradiation in patients with mild Graves’ ophthalmopathy. J Clin Endocrinol Metab 89(1):15–20

    Google Scholar 

  • Ramanathan R et al (2015) Local allograft irradiation as an adjunct for treating severe resistant rejection after liver transplantation in adults. Liver Transpl 21(1):47–56. ISSN 1527-6473. https://www.ncbi.nlm.nih.gov/pubmed/25287272

    Google Scholar 

  • Ravin JG, Sisson JC, Knapp WT (1975a) Orbital radiation in Graves’ disease: reply. Am J Ophthalmol 79(5):889

    Google Scholar 

  • Ravin JG, Sisson JC, Knapp WT (1975b) Orbital radiation for the ocular changes of Graves’ disease. Am J Ophthalmol 79(2):285–288

    Google Scholar 

  • Robinson AC et al (1984) Idiopathic midline destructive disease—case report and review of the literature. Postgrad Med J 60(705):471–473

    Google Scholar 

  • Ruey-Bin C et al (1988) Treatment of “idiopathic midline destructive disease” by irradiation. J Craniomaxillofac Surg 16:375–378

    Google Scholar 

  • Schaaf L et al (1989) Reduction by orbital radiation of cumulative doses of glucocorticoids in patients with Graves’-Basedow ophthalmopathy. Dev Ophthalmol 20:155–158

    Google Scholar 

  • Schulz MD, Schwab RS (1971) Results of thymic (mediastinal) irradiation in patients with myasthenia gravis. Ann N Y Acad Sci 183:303–307

    Google Scholar 

  • Shackman R, Dempster WJ, Wrong OM (1963. ISSN 0007-1331) Kidney homotransplantation in the human. Br J Urol 35(3):222–255. https://doi.org/10.1111/J.1464-410x.1963.Tb06900.x

    Article  Google Scholar 

  • Smalley SR et al (1988) Polymorphic reticulosis limited to the upper aerodigestive tract-natural history and radiotherapeutic considerations. Int J Radiat Oncol Biol Phys 15(3):599–605

    Google Scholar 

  • Stiebel-Kalish H et al (2009) Treatment modalities for Graves’ ophthalmopathy: systematic review and meta-analysis. J Clin Endocrinol Metab 94(8):2708–2716

    Google Scholar 

  • Strober S (1985. ISSN 0003-4819) Treatment of intractable lupus nephritis with total lymphoid irradiation. Ann Intern Med 102(4):450. https://doi.org/10.7326/0003-4819-102-4-450

    Article  Google Scholar 

  • Strober S (1987. ISSN 0003-4819) Lupus nephritis after total lymphoid irradiation: persistent improvement and reduction of steroid therapy. Ann Intern Med 107(5):689. https://doi.org/10.7326/0003-4819-107-5-689

    Article  Google Scholar 

  • Tajiri J (2006) Radioactive iodine therapy for goitrous Hashimoto’s thyroiditis. J Clin Endocrinol Metab 11:4497–4500

    Google Scholar 

  • Tallaj JA et al (2011) Total lymphoid irradiation in heart transplantation: long-term efficacy and survival—an 18-year experience. Transplantation 92(10):1159–1164. ISSN 1534-6080. https://www.ncbi.nlm.nih.gov/pubmed/22015463

    Google Scholar 

  • Teng CS et al (1980) An evaluation of supervoltage orbital irradiation for Graves’ ophthalmopathy. Clin Endocrinol (Oxf) 13(6):545–551

    Google Scholar 

  • Thomson JA, Jackson IMD, Duguid WP (1968) The effect of steroid therapy on Riedel’s thyroiditis. Scott Med J 13:13–16

    Google Scholar 

  • Tourtellotte WW (1980. ISSN 0003-9942) Multiple sclerosis de novo CNS IgG synthesis. Arch Neurol 37(10):620. https://doi.org/10.1001/archneur.1980.00500590044005

    Article  Google Scholar 

  • Trobe JD (1978) Dysthyroid optic neuropathy. Arch Ophthalmol 96(7):1199

    Google Scholar 

  • Tubiana M, Lalanne CM, Surmont J (1961. ISSN 0035-9157) Total body irradiation for organ transplantation. Proc R Soc Med 54(12):1143–1150. https://doi.org/10.1177/003591576105401225

    Article  Google Scholar 

  • Vagenakis AG, Abreau CM, Braverman LE (1970) Prevention of recurrence in acute thyroiditis following corticosteroid withdrawal. J Clin Endocrinol Metab 31:705–708

    Google Scholar 

  • van Ouwerkerk BM et al (1985) Radiotherapy of severe ophthalmic Graves’ disease. J Endocrinol Invest 8(3):241–247

    Google Scholar 

  • Vanrenterghem Y et al (1984) Cadaveric kidney transplantation in diabetics after total lymphoid irradiation (TLI). Transplant Proc 16(3):636–639

    Google Scholar 

  • Varl B, Kastelic B, Porenta M (1968) The therapeutic effect of a diagnostic dose of radioactive iodine on the subacute De Quervain thyroiditis. Strahlentherapie 36:162–169

    Google Scholar 

  • Vessey MP, Doll R (1972) Thymectomy and cancer—a follow-up study. Br J Cancer 26:53–58

    Google Scholar 

  • Waer M et al (1985) Total lymphoid irradiation in renal cadaveric transplantation in diabetics. Lancet 326(8468):1354

    Google Scholar 

  • Wahl AO et al (2006) Radiotherapy for rejection of renal transplant allografts refractory to medical immunosuppression. Am J Clin Oncol 29(6):551–554. ISSN 1537-453x. https://www.ncbi.nlm.nih.gov/pubmed/17148990

    Google Scholar 

  • Wei J et al (2021) Radiotherapy of granulomatosis with polyangiitis occurring in the eyelid: a case report and literature review. Medicine (Baltimore) 100(3):e22794

    Google Scholar 

  • Weissberg D, Goldberg M, Pearson FG (1973) Thymoma. Ann Thorac Surg 16:141–147

    Google Scholar 

  • Wiersinga WM et al (1988) Therapeutic outcome of prednisone medication and of orbital irradiation in patients with Graves’ ophthalmopathy. Ophthalmologica 197(2):75–84

    Google Scholar 

  • Wildermuth O (1962) Lethal midline granuloma. Radiology 78(2):269–271

    Google Scholar 

  • Wiles CM et al (1994) Total lymphoid irradiation in multiple sclerosis. J Neurol Neurosurg Psychiatry 57(2):154–163. ISSN 0022-3050. https://www.ncbi.nlm.nih.gov/pubmed/8126497

    Google Scholar 

  • Wolden SL et al (1997) Long-term results of total lymphoid irradiation in the treatment of cardiac allograft rejection. Int J Radiat Oncol Biol Phys 39(5):953–960. ISSN 0360-3016. https://www.ncbi.nlm.nih.gov/pubmed/9392531

    Google Scholar 

  • Wolf SM (1966) The relationship between thymoma and myasthenia gravis. Bull Los Angel Neuro Soc 31:107–113

    Google Scholar 

  • Woodruff MFA (1964) The management of patients given whole-body irradiation or antimetabolites to promote the survival of a renal homotransplant. Clin Radiol 15(1):30–34

    Google Scholar 

  • Woodruff MFA et al (1963. ISSN 0140-6736) Homotransplantation of kidney in patients treated by preoperative local irradiation and postoperative administration of an antimetabolite (IMURAN). Lancet 282(7309):675–682. https://doi.org/10.1016/S0140-6736(63)90465-3

    Article  Google Scholar 

  • Yamamoto K et al (1982) Treatment of Graves’ ophthalmopathy by steroid therapy, orbital radiation therapy, plasmapheresis and thyroxine replacement. Endocrinol Jpn 29(4):495–501

    Google Scholar 

  • Yamamoto K et al (1983) Diagnosis of exophthalmos using orbital ultrasonography and treatment of malignant exophthalmos with steroid therapy, orbital radiation therapy, and plasmapheresis. Prog Clin Biol Res 116:189–205

    Google Scholar 

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  1. Department of Radiation Oncology, Stanford University, Palo Alto, CA, USA

    Andrew Martella, Yushen Qian & Rishabh Chaudhari

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Correspondence to Andrew Martella .

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  1. Department of Radiation Oncology, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada

    David Roberge

  2. Department of Radiation Oncology, Stanford Medicine, Palo Alto, CA, USA

    Sarah S. Donaldson

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Martella, A., Qian, Y., Chaudhari, R. (2023). Autoimmune Disorders. In: Roberge, D., Donaldson, S.S. (eds) Radiation Therapy of Benign Diseases. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2022_370

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