Abstract
Radiation therapy (RT) plays an important role in the management of recurrent lung cancer after surgery or definitive RT, not only for palliative but also for curative purposes. Definitive RT for locoregional recurrence after surgical resection facilitates comparative survival for de novo stage III lung cancer with acceptable toxicities. Recent technological advances in beam delivery for highly conformal RT (SBRT, IMRT, proton, etc.) and imaging modalities (FDG PET for early detection of tumor recurrence, 4D CT for precise target delineation in treatment planning, cone beam CT for daily patient positioning, etc.) have permitted reirradiation of patients for curative purposes, which had been previously considered difficult. A better performance status with good pulmonary function, a longer period after previous RT, and a smaller volume of the recurrent tumor may facilitate better survival. However, reirradiation is associated with a potential risk of severe toxicities. When applying reirradiation, careful attention to the proximity of the recurrent tumor to organs at risk and evaluation of cumulative dose distributions are needed. In palliative settings, thoracic RT offers quick and efficient palliation of symptoms.
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This work is partially supported by AMED under Grant Number JP20ck0106427.
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Matsuo, Y., Hanazawa, H., Kishi, N., Ueki, K., Mizowaki, T. (2022). Radiation Therapy for Intrathoracic Recurrence of Lung Cancer. In: Jeremić, B. (eds) Advances in Radiation Oncology in Lung Cancer. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2022_328
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