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Prophylactic Cranial Irradiation in Non-small Cell Lung Cancer

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Advances in Radiation Oncology in Lung Cancer

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

The incidence of brain metastases following definitive intent treatment for locally advanced non-small cell lung cancer (LA-NSCLC) is high. Failures in the brain are associated with poor prognosis, impaired function, and poor quality of life. Brain failures are particularly devastating when the disease is otherwise cured. PCI has consistently been shown to decrease brain failures although it is not the standard of care. There has been a sustained, although unsuccessful, interest over the last several decades to demonstrate that PCI improves overall survival in appropriately selected patients with LA-NSCLC. This chapter provides a comprehensive updated review of the risks of brain metastases and the potential role of PCI in LA-NSCLC with a review of seven prospective randomized trials.

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Authors and Affiliations

  1. Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA

    Hina Saeed, Monica E. Shukla & Elizabeth M. Gore

Authors
  1. Hina Saeed
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  2. Monica E. Shukla
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  3. Elizabeth M. Gore
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Corresponding author

Correspondence to Elizabeth M. Gore .

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Editors and Affiliations

  1. School of Medicine, University of Kragujevac, Kragujevac, Serbia

    Branislav Jeremić

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Saeed, H., Shukla, M.E., Gore, E.M. (2022). Prophylactic Cranial Irradiation in Non-small Cell Lung Cancer. In: Jeremić, B. (eds) Advances in Radiation Oncology in Lung Cancer. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2022_322

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  • DOI: https://doi.org/10.1007/174_2022_322

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  • Print ISBN: 978-3-031-34846-4

  • Online ISBN: 978-3-031-34847-1

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