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Radioprotectors in the Management of Lung Cancer

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Advances in Radiation Oncology in Lung Cancer

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Radiation therapy has become increasingly important in the management of lung cancer at all stages. However, radiotherapy, given alone or with concurrent chemo- and immunotherapy, can have severe adverse effects on critical organs that are often in the path of the radiation beam depending on the location of the tumor. Immune checkpoint inhibitor therapy also has its own adverse effects that include inflammation of the lung (interstitial pneumonitis) and heart (myocarditis, pericarditis). In the randomized phase III PACIFIC clinical trial (Antonia et al. 2018) of lung cancer treated with concurrent chemoradiation therapy to be followed by durvalumab or placebo, only patients who did not develop symptomatic toxicity after the chemoradiation were randomized, which excluded at least 35–40% patients from the potential benefits of checkpoint inhibitor therapy because of concern over severe adverse sequelae. The ability to counteract the toxic effects of radiation, chemotherapy, and immune checkpoint inhibitors in their various combinations is imperative if treatment is to be curative without compromising quality of life.

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Acknowledgment

The authors are in debt to Christine Wogan for her editorial expertise in the development of this chapter.

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Authors and Affiliations

  1. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Zhongxing Liao & Ting Xu

  2. Department of Radiation Oncology, Baylor College of Medicine, Houston, TX, USA

    Ritsuko Komaki

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  1. Zhongxing Liao
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Correspondence to Zhongxing Liao .

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  1. School of Medicine, University of Kragujevac, Kragujevac, Serbia

    Branislav Jeremić

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Liao, Z., Xu, T., Komaki, R. (2022). Radioprotectors in the Management of Lung Cancer. In: Jeremić, B. (eds) Advances in Radiation Oncology in Lung Cancer. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2022_310

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