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Endometrial Cancer

  • Mariana HortaEmail author
  • Teresa Margarida Cunha
Part of the Medical Radiology book series (MEDRAD)

Abstract

Endometrial cancer is the most common gynecological malignancy in well-developed countries. Biologically and clinicopathologically, endometrial carcinomas are divided into two types: type 1 or estrogen-dependent carcinomas and type 2 or estrogen-independent carcinomas. Type 1 cancers correspond mainly to endometrioid carcinomas and account for approximately 90 % of endometrial cancers, whereas type 2 cancers correspond to the majority of the other histopathological subtypes.

The vast majority of endometrial cancers present as abnormal vaginal bleedings in postmenopausal women. Therefore, 75 % of cancers are diagnosed at an early stage, which makes the overall prognosis favorable.

The first diagnostic step to evaluate women with an abnormal vaginal bleeding is the measurement of the endometrial thickness with transvaginal ultrasound. If endometrial thickening or heterogeneity is confirmed, a biopsy should be performed to establish a definite histopathological diagnosis.

Magnetic resonance imaging is not considered in the International Federation of Gynaecology and Obstetrics staging system. Nonetheless it plays a relevant role in the preoperative staging of endometrial carcinoma, helping to define the best therapeutic management. Moreover, it is important in the diagnosis of treatment complications, in the surveillance of therapy response, and in the assessment of recurrent disease.

Keywords

Endometrial cancer Magnetic resonance imaging Gynecology Radiology 

References

  1. Amant F, Moerman P, Neven P, Timmerman D, Van Limbergen E, Vergote I (2005) Endometrial cancer. Lancet 366(9484):491–505CrossRefGoogle Scholar
  2. Amant F, Moerman P, Neven P, Timmerman D, Van Limbergen E, Vergote I (2007) Treatment modalities in endometrial cancer. Curr Opin Oncol 19(5):479–485CrossRefGoogle Scholar
  3. Andreano A, Rechichi G, Rebora P, Sironi S, Valsecchi MG, Galimberti S (2014) MR diffusion imaging for preoperative staging of myometrial invasion in patients with endometrial cancer: a systematic review and meta-analysis. Eur Radiol 24(6):1327–1338. doi:10.1007/s00330-014-3139-4CrossRefPubMedGoogle Scholar
  4. ASTEC Study Group, Kitchener H, Swart AM, Qian Q, Amos C, Parmar MK (2009) Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. Lancet 373(9658):125–136. doi:10.1016/S0140-6736(08)61766-3CrossRefGoogle Scholar
  5. Beddy P, Moyle P, Kataoka M, Yamamoto AK, Joubert I, Lomas D et al (2012) Evaluation of depth of myometrial invasion and overall staging in endometrial cancer: comparison of diffusion-weighted and dynamic contrast-enhanced MR imaging. Radiology 262(2):530–537. doi:10.1148/radiol.11110984CrossRefPubMedGoogle Scholar
  6. Benedetti Panici P, Basile S, Maneschi F, Alberto Lissoni A, Signorelli M, Scambia G et al (2008) Systematic pelvic lymphadenectomy vs no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. J Natl Cancer Inst 100(23):1707–1716. doi:10.1093/jnci/djn397CrossRefPubMedGoogle Scholar
  7. Bennet GL, Andreotti RF, Lee SI, Dejesus Allison SO, Brown DL, Dubinsky T et al (2011 Jul) ACR Appropriateness Criteria® on Abnormal Vaginal Bleeding. J Am Coll Radiol 8(7):460–468. doi:10.1016/j.jacr.2011.03.011CrossRefGoogle Scholar
  8. Bharwani N, Miquel ME, Sahdev A, Narayanan P, Malietzis G, Reznek RH et al (2011) Diffusion-weighted imaging in the assessment of tumour grade in endometrial cancer. Br J Radiol 84(1007):997–1004. doi:10.1259/bjr/14980811CrossRefPubMedPubMedCentralGoogle Scholar
  9. Bonatti M, Stuefer J, Oberhofer N, Negri G, Tagliaferri T, Schifferle G et al (2015) MRI for local staging of endometrial carcinoma: is endovenous contrast medium administration still needed? Eur J Radiol 84(2):208–214. doi:10.1016/j.ejrad.2014.11.010CrossRefPubMedGoogle Scholar
  10. Boronow RC (1990) Advances in diagnosis, staging, and management of cervical and endometrial cancer Stages I and II. Cancer 65(3 Suppl):648–659CrossRefGoogle Scholar
  11. Briët JM, Hollema H, Reesink N, Aalders JG, Mourits MJE, Hoor ten KA et al (2005) Lymphvascular space involvement: an independent prognostic factor in endometrial cancer. Gynecol Oncol 96(3):799–804CrossRefGoogle Scholar
  12. Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4(8):579–591CrossRefGoogle Scholar
  13. Colombo N, Preti E, Landoni F, Carinelli S, Colombo A, Marini C et al (2013) Endometrial cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 24(Suppl 6):vi33–vi38. doi:10.1093/annonc/mdt353CrossRefPubMedGoogle Scholar
  14. Colombo N, Creutzberg C, Amant F, Bosse T, González-Martín A, Ledermann J et al (2016) ESMO-ESGO-ESTRO consensus conference on endometrial cancer: diagnosis, treatment and follow-up. Int J Gynecol Cancer 26(1):2–30. doi:10.1097/IGC.0000000000000609CrossRefPubMedGoogle Scholar
  15. Creasman W (2009) Revised FIGO staging for carcinoma of the endometrium. Int J Gynaecol Obstet 105(2):109. doi:10.1016/j.ijgo.2009.02.010CrossRefPubMedGoogle Scholar
  16. Eichhorn JH, Young RH (2001) Neuroendocrine tumors of the genital tract. Am J Clin Pathol 115(Suppl):S94–112PubMedGoogle Scholar
  17. Epstein E, Blomqvist L (2014) Imaging in endometrial cancer. Best Pract Res Clin Obstet Gynaecol 28(5):721–739. doi:10.1016/j.bpobgyn.2014.04.007CrossRefPubMedGoogle Scholar
  18. Fanning J, Tsukada Y, Piver MS (1990) Intraoperative frozen section diagnosis of depth of myometrial invasion inendometrial adenocarcinoma. Gynecol Oncol 37(1):47–50CrossRefGoogle Scholar
  19. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M et al (2013) Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon: International Agency for Research on Cancer. Available from: http://globocan.iarc.fr. Accessed 23 May 2015
  20. Fisher B, Costantino JP, Redmond CK, Fisher ER, Wickerham DL, Cronin WM (1994) Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14. J Natl Cancer Inst 86(7):527–537CrossRefGoogle Scholar
  21. Frei KA, Kinker K (2001) Staging endometrial cancer: role of magnetic resonance imaging. J Magn Reson Imaging 13(6):850–855CrossRefGoogle Scholar
  22. Frei KA, Kinkel K, Bonél HM, Lu Y, Zaloudek C, Hricak H (2000) Prediction of deep myometrial invasion in patients with endometrial cancer: clinical utility of contrast-enhanced MR imaging–a meta-analysis and bayesian analysis. Radiology 216(2):444–449CrossRefGoogle Scholar
  23. Fujii S, Matsusue E, Kigawa J, Sato S, Kanasaki Y, Nakanishi J et al (2008) Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results. Eur Radiol 18(2):384–389CrossRefGoogle Scholar
  24. Fujii S, Kido A, Baba T, Fujimoto K, Daido S, Matsumura N (2015) Subendometrial enhancement and peritumoral enhancement for assessing endometrial cancer on dynamic contrast enhanced MR imaging. Eur J Radiol 84(4):581–589. doi:10.1016/j.ejrad.2015.01.004CrossRefPubMedGoogle Scholar
  25. Gallego JC, Porta A, Pardo MC, Fernández C (2014) Evaluation of myometrial invasion in endometrial cancer: comparison of diffusion-weighted magnetic resonance and intraoperative frozen sections. Abdom Imaging 39(5):1021–1026. doi:10.1007/s00261-014-0134-9CrossRefPubMedGoogle Scholar
  26. Goldstein RB, Bree RL, Benson CB, Benacerraf BR, Carlos R et al (2001) Evaluation of the woman with postmenopausal bleeding: society of radiologists in ultrasound-sponsored consensus conference statement. J Ultrasound Med 20(10):1025–1036CrossRefGoogle Scholar
  27. Gull B, Karlsson B, Milsom I, Granber S (2003) Can ultrasound replace dilation and curettage? A longitudinal evaluation of postmenopausal bleeding and transvaginal sonographic measurement of the endometrium as predictors of endometrial cancer. Am J Obstet Gynecol 188(2):401–408CrossRefGoogle Scholar
  28. Gupta JK, Chien PF, Voit D, Clark TJ, Khan KS (2002) Ultrasonographic endometrial thickness for diagnosing endometrial pathology in women with postmenopausal bleeding: a meta-analysis. Acta Obstet Gynecol Scand 81(9):799–816CrossRefGoogle Scholar
  29. Haider MA, Patlas M, Jhaveri K, Chapman W, Fyles A, Rosen B (2006) Adenocarcinoma involving the uterine cervix: magnetic resonance imaging findings in tumours of endometrial, compared with cervical, origin. Can Assoc Radiol J 57(1):43–48PubMedGoogle Scholar
  30. Haldorsen IS, Salvesen HB (2012) Staging of endometrial carcinomas with MRI using traditional and novel MRI techniques. Clin Radiol 67(1):2–12. doi:10.1016/j.crad.2011.02.018CrossRefPubMedGoogle Scholar
  31. Haldorsen IS, Grüner R, Husby JA, Magnussen IJ, Werner HMJ, Salvesen ØO et al (2013) Dynamic contrast-enhanced MRI in endometrial carcinoma identifies patients at increased risk of recurrence. Eur Radiol 23(10):2916–2925. doi:10.1007/s00330-013-2901-3CrossRefPubMedGoogle Scholar
  32. Hecht JL, Mutter GL (2006) Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol 24(29):4783–4791CrossRefGoogle Scholar
  33. Hori M, Kim T, Onishi H, Imaoka I, Kagawa Y, Murakami T et al (2013) Endometrial cancer: preoperative staging using three-dimensional T2-weighted turbo spin-echo and diffusion-weighted MR imaging at 3.0 T: a prospective comparative study. Eur Radiol 23(8):2296–2305. doi:10.1007/s00330-013-2815-0CrossRefPubMedGoogle Scholar
  34. Hulka CA, Hall DA, McCarthy K, Simeone JF (1994) Endometrial polyps, hyperplasia, and carcinoma in postmenopausal women: differentiation with endovaginal sonography. Radiology 191(3):755–758CrossRefGoogle Scholar
  35. Ippolito D, Minutolo O, Cadonici A, Talei Franzesi C, Bonaffini P, Perego P et al (2014a) Endometrial cancer: diagnostic value of quantitative measurements of microvascular changes with DCE-MR imaging. MAGMA 27(6):531–538. doi:10.1007/s10334-014-0435-6CrossRefPubMedGoogle Scholar
  36. Ippolito D, Cadonici A, Bonaffini PA, Minutolo O, Casiraghi A, Perego P et al (2014b) Semiquantitative perfusion combined with diffusion-weighted MR imaging in pre-operative evaluation of endometrial carcinoma: Results in a group of 57 patients. Magn Reson Imaging 32(5):464–472. doi:10.1016/j.mri.2014.01.009CrossRefPubMedGoogle Scholar
  37. Jafari Shobeiri M, Mostafa Gharabaghi P, Esmaeili H, Ouladsahebmadarek E, Mehrzad-Sadagiani M (2013) Fertility sparing treatment in young patients with early endometrial adenocarcinoma: case series. Pak J Med Sci 29(2):651–655CrossRefGoogle Scholar
  38. Jalloul RJ, Elshaikh MA, Ali-Fehmi R, Haley MM, Yoon J, Mahan M et al (2012) Mucinous adenocarcinoma of the endometrium. Int J Gynecol Cancer 22(5):812–818. doi:10.1097/IGC.0b013e31824aCrossRefPubMedGoogle Scholar
  39. Järvinen HJ, Renkonen-Sinisalo L, Aktán-Collán K, Peltomäki P, Aaltonen LA, Mecklin J-P (2009) Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members. J Clin Oncol 27(28):4793–4797. doi:10.1200/JCO.2009.23.7784CrossRefPubMedGoogle Scholar
  40. Kaneda S, Fujii S, Fukunaga T, Kakite S, Kaminou T, Kigawa J et al (2011) Myometrial invasion by endometrial carcinoma: evaluation with 3.0 T MR imaging. Abdom Imaging 36(5):612–618. doi:10.1007/s00261-011-9719-8CrossRefPubMedGoogle Scholar
  41. Karlsson B, Granberg S, Wikland M, Ylostalo P, Torvid K, Marsal K et al (1995) Transvaginal ultrasonography of the endometrium in women withpostmenopausal bleeding—a Nordic multicenter study. Am J Obstet Gynecol 172(5):1488–1494CrossRefGoogle Scholar
  42. Kesterson JP, Fanning J (2012) Fertility-sparing treatment of endometrial cancer: options, outcomes and pitfalls. J Gynecol Oncol 23(2):120–124. doi:10.3802/jgo.2012.23.2.120CrossRefPubMedPubMedCentralGoogle Scholar
  43. Kinkel K (2006) Pitfalls in staging uterine neoplasm with imaging: a review. Abdom Imaging 31(2):164–173CrossRefGoogle Scholar
  44. Kitajima K, Murakami K, Yamasaki E, Domeki Y, Kaji Y, Morita S et al (2008) Performance of integrated FDG-PET/contrast-enhanced CT in the diagnosis of recurrent uterine cancer: comparison with PET and enhanced CT. Eur J Nucl Med Mol Imaging 36(3):362–372. doi:10.1007/s00259-008-0956-1CrossRefPubMedGoogle Scholar
  45. Klopp A, Smith BD, Alektiar K, Cabrera A, Damato AL, Erikson B et al (2014) The role of postoperative radiation therapy for endometrial cancer: Executive Summary of an American Society for Radiation Oncology evidence-based guideline. Pract Radiat Oncol 4(3):137–144. doi:10.1016/j.prro.2014.01.003CrossRefPubMedGoogle Scholar
  46. Koh WJ, Greer BE, Abu-Rustum NR, Apte SM, Campos SM, Chan J et al (2014) Uterine Neoplasms, version 1.2014. J Natl Compr Canc Netw 12(2):248–280CrossRefGoogle Scholar
  47. Koyama T, Tamai K, Togashi K (2007) Staging of carcinoma of the uterine cervix and endometrium. Eur Radiol 17(8):2009–2019CrossRefGoogle Scholar
  48. Kurman RJ, Carcangiu ML, Herrington CS, Young RH (2014) Tumours of the Uterine Corpus. In: WHO classification of tumours of female reproductive organs, vol 6, 4th edn. International Agency for Research on Cancer, Lyon, pp. 121–155Google Scholar
  49. Larson DM, Connor GP, Broste SK, Krawisz BR, Johnson KK (1996) Prognostic significance of gross myometrial invasion with endometrial cancer. Obstet Gynecol 88(3):394–398CrossRefGoogle Scholar
  50. Lopes Dias J, Cunha TM, Gomes FV, Callé C, Félix A (2015) Neuroendocrine tumours of the female genital tract: a case-based imaging review with pathological correlation. Insights Imaging 6(1):43–52. doi:10.1007/s13244-014-0378-5CrossRefPubMedPubMedCentralGoogle Scholar
  51. Magrina JF, Zanagnolo V, Giles D, Noble BN, Kho RM, Magtibay PM (2011) Robotic surgery for endometrial cancer: comparison of perioperative outcomes and recurrence with laparoscopy, vaginal/laparoscopy and laparotomy. Eur J Gynaecol Oncol 32(5):476–480PubMedGoogle Scholar
  52. Manfredi R, Mirk P, Maresca G, Margariti PA, Testa A, Zannoni GF et al (2004) Local-regional staging of endometrial carcinoma: role of MR imaging in surgical planning. Radiology 231(2):372–378CrossRefGoogle Scholar
  53. Manfredi R, Gui B, Maresca G, Fanfani F, Bonomo L (2005) Endometrial cancer: magnetic resonance imaging. Abdom Imaging 30(5):626–636CrossRefGoogle Scholar
  54. May K, Bryant A, Dickinson HO, Kehoe S, Morrison J (2010) Lymphadenectomy for the management of endometrial cancer. Cochrane Database Syst Rev 20(1):CD007585. doi:10.1002/14651858.CD007585.pub2CrossRefGoogle Scholar
  55. McPherson CP, Sellers TA, Potter JD, Bostick RM, Folsom AR (1996) Reproductive factors and risk of endometrial cancer. The Iowa Women's Health Study. Am J Epidemiol 143(12):1195–1202CrossRefGoogle Scholar
  56. Meyer LA, Broaddus RR, Lu KH (2009) Endometrial cancer and Lynch syndrome: clinical and pathologic considerations. Cancer Control 16(1):14–22CrossRefGoogle Scholar
  57. Nakai G, Matsuki M, Inada Y, Tatsugami F, Tanikake M, Narabayashi I et al (2008) Detection and evaluation of pelvic lymph nodes in patients with gynecologic malignancies using body diffusion-weighted magnetic resonance imaging. J Comput Assist Tomogr 32(5):764–768. doi:10.1097/RCT.0b013e318153fd43CrossRefGoogle Scholar
  58. Nakao Y, Yokoyama M, Hara K, Koyamatsu Y, Yasunaga M, Araki Y et al (2006) MR imaging in endometrial carcinoma as a diagnostic tool for the absence of myometrial invasion. Gynecol Oncol 102(2):343–347CrossRefGoogle Scholar
  59. Nougaret S, Tirumani SH, Addley H, Pandey H, Sala E, Reinhold C (2013) Pearls and pitfalls in MRI of gynecologic malignancy with diffusion-weighted technique. AJR Am J Roentgenol 200(2):261–276. doi:10.2214/AJR.12.9713CrossRefPubMedGoogle Scholar
  60. Nougaret S, Reinhold C, Alsharif SS, Addley H, Arceneau J, Molinari N et al (2015) Endometrial cancer: combined MR volumetry and diffusion-weighted imaging for assessment of myometrial and lymphovascular invasion and tumor grade. Radiology 276(3):797–808. doi:10.1148/radiol.15141212CrossRefPubMedPubMedCentralGoogle Scholar
  61. Numazaki R, Miyagi E, Konnai K, Ikeda M, Yamamoto A, Onose R et al (2009) Analysis of stage IVB endometrial carcinoma patients with distant metastasis: a review of prognoses in 55 patients. Int J Clin Oncol 14(4):344–350. doi:10.1007/s10147-009-0878-3CrossRefPubMedGoogle Scholar
  62. Patel S, Liyanage SH, Sahdev A, Rockall AG, Reznek RH (2010) Imaging of endometrial and cervical cancer. Insights Imaging 1(5–6):309–328CrossRefGoogle Scholar
  63. Pecorelli S (2009) Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 105(2):103–104CrossRefGoogle Scholar
  64. Rechichi G, Galimberti S, Signorelli M, Perego P, Valsecchi MG, Sironi S (2010) Myometrial invasion in endometrial cancer: diagnostic performance of diffusion-weighted MR imaging at 1.5-T. Eur Radiol 20(3):754–762. doi:10.1007/s00330-009-1597-xCrossRefPubMedGoogle Scholar
  65. Rechichi G, Galimberti S, Signorelli M, Franzesi CT, Perego P, Valsecchi MG et al (2011) Endometrial cancer: correlation of apparent diffusion coefficient with tumor grade, depth of myometrial invasion, and presence of lymph node metastases. AJR Am J Roentgenol 197(1):256–262. doi:10.2214/AJR.10.5584CrossRefPubMedGoogle Scholar
  66. Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569–578. doi:10.1016/S0140-6736(08)60269-XCrossRefPubMedGoogle Scholar
  67. Resnick KE, Hampel H, Fishel R, Cohn DE (2009) Current and emerging trends in Lynch syndrome identification in women with endometrial cancer. Gynecol Oncol 114(1):128–134. doi:10.1016/j.ygyno.2009.03.003 Epub 2009 Apr 17CrossRefPubMedPubMedCentralGoogle Scholar
  68. Roy C, Bierry G, Matau A, Bazille G, Pasquali R (2010) Value of diffusion-weighted imaging to detect small malignant pelvic lymph nodes at 3 T. Eur Radiol 20(8):1803–1811. doi:10.1007/s00330-010-1736-4CrossRefPubMedGoogle Scholar
  69. Saez F, Urresola A, Larena JA, Martín JI, Pijuán JI, Schneider J et al (2000) Endometrial carcinoma: assessment of myometrial invasion with plain and gadolinium-enhanced MR imaging. J Magn Reson Imaging 12(3):460–466CrossRefGoogle Scholar
  70. Sala E, Rockall A, Rangarajan D, Kubik-Huch RA (2010) The role of dynamic contrast-enhanced and diffusion weighted magnetic resonance imaging in the female pelvis. Eur J Radiol 76(3):367–385. doi:10.1016/j.ejrad.2010.01.026CrossRefPubMedPubMedCentralGoogle Scholar
  71. Sala E, Rockall AG, Freeman SJ, Mitchell DG, Reinhold C (2013) The added role of MR imaging in treatment stratification of patients with gynecologic malignancies: what the radiologist needs to know. Radiology 266(3):717–740. doi:10.1148/radiol.12120315CrossRefPubMedPubMedCentralGoogle Scholar
  72. Salani R, Backes FJ, Fung MF, Holschneider CH, Parker LP, Bristow RE et al (2011 Jun) Posttreatment surveillance and diagnosis of recurrence in women with gynecologic malignancies: society of Gynecologic Oncologists recommendations. Am J Obstet Gynecol 204(6):466–478. doi:10.1016/j.ajog.2011.03.008CrossRefPubMedGoogle Scholar
  73. Schmeler KM, Lynch HT, Chen LM, Munsell MF, Soliman PT, Clark MB et al (2006) Prophylactic surgery to reduce the risk of gynecologic cancers in the lynch syndrome. N Engl J Med 354(3):261–269CrossRefGoogle Scholar
  74. Scoutt LM, McCarthy SM, Flynn SD, Lange RC, Long F, Smith RC et al (1995) Clinical stage I endometrial carcinoma: pitfalls in preoperative assessment with MR imaging Work in progress. Radiology 194(2):567–572CrossRefGoogle Scholar
  75. Seki H, Takano T, Sakai K (2000) Value of dynamic MR imaging in assessing endometrial carcinoma involvement of the cervix. AJR Am J Roentgenol 175(1):171–176CrossRefGoogle Scholar
  76. Setiawan VW, Yang HP, Pike MC, McCann SE, Yu H, Xiang Y-B et al (2013) Type I and II endometrial cancers: have they different risk factors? J Clin Oncol 31(20):2607–2618. doi:10.1200/JCO.2012.48.2596CrossRefPubMedPubMedCentralGoogle Scholar
  77. Shapiro S, Kelly JP, Rosenberg L, Kaufman DW, Helmrich SP, Rosenshein NB et al (1985) Risk of localized and widespread endometrial cancer in relation to recent and discontinued use of conjugated estrogens. N Engl J Med 313(16):969–972CrossRefGoogle Scholar
  78. Shen S-H, Chiou Y-Y, Wang J-H, Yen M-S, Lee R-C, Lai C-R et al (2008) Diffusion-weighted single-shot echo-planar imaging with parallel technique in assessment of endometrial cancer. Am J Roentgenol 190(2):481–488. doi:10.2214/AJR.07.2155CrossRefGoogle Scholar
  79. Smith-Bindman R, Kerlikowske K, Feldstein VA, Subak L, Scheidler J, Segal M et al (1998) Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities. JAMA 280(17):1510–1517CrossRefGoogle Scholar
  80. Sohaib SA, Houghton SL, Meroni R, Rockall AG, Blake P, Reznek RH (2007) Recurrent endometrial cancer: patterns of recurrent disease and assessment of prognosis. Clin Radiol 62(1):28–34CrossRefGoogle Scholar
  81. Soliman PT, Wu D, Tortolero-Luna G, Schmeler KM, Slomovitz BM, Bray MS et al (2006) Association between adiponectin, insulin resistance, and endometrial cancer. Cancer 106(11):2376–2381CrossRefGoogle Scholar
  82. Soliman PT, Frumovitz M, Spannuth W, Greer MJ, Sharma S, Schmeler KM et al (2010 Nov) Lymphadenectomy during endometrial cancer staging: Practice patterns among gynecologic oncologists. Gynecol Oncol 119(2):291–294. doi:10.1016/j.ygyno.2010.07.011CrossRefPubMedPubMedCentralGoogle Scholar
  83. Takeuchi M, Matsuzaki K, Nishitani H (2009) Diffusion-weighted magnetic resonance imaging of endometrial cancer: differentiation from benign endometrial lesions and preoperative assessment of myometrial invasion. Acta Radiol 50(8):947–953. doi:10.1080/02841850903099981CrossRefPubMedGoogle Scholar
  84. Tamai K, Koyama T, Saga T, Umeoka S, Mikami Y, Fujii S et al (2007) Diffusion-weighted MR imaging of uterine endometrial cancer. J Magn Reson Imaging 26(3):682–687CrossRefGoogle Scholar
  85. Tirumani SH, Shanbhogue AK, Prasad SR (2013) Current concepts in the diagnosis and management of endometrial and cervical carcinomas. Radiol Clin North Am 51(6):1087–1110. doi:10.1016/j.rcl.2013.07.003CrossRefPubMedGoogle Scholar
  86. Todo Y, Kato H, Kaneuchi M, Watari H, Takeda M, Sakuragi N (2010) Survival effect of para-aortic lymphadenectomy in endometrial cancer (SEPAL study): a retrospective cohort analysis. Lancet 375(9721):1165–1172. doi:10.1016/S0140-6736(09)62002-XCrossRefPubMedGoogle Scholar
  87. Vargas HA, Akin O, Zheng J, Moskowitz C, Soslow R, Abu-Rustum N et al (2011) The value of MR imaging when the site of uterine cancer origin is uncertain. Radiology 258(3):785–792. doi:10.1148/radiol.10101147CrossRefPubMedGoogle Scholar
  88. Venkat P, Chen LM, Young-Lin N, Kiet TK, Young G, Amatori D et al (2012) An economic analysis of robotic versus laparoscopic surgery for endometrial cancer: costs, charges and reimbursements to hospitals and professionals. Gynecol Oncol 125(1):237–240. doi:10.1016/j.ygyno.2011.11.036CrossRefPubMedGoogle Scholar
  89. Wakefield JC, Downey K, Kyriazi S, deSouza NM (2013) New MR techniques in gynecologic cancer. AJR Am J Roentgenol 200(2):249–260. doi:10.2214/AJR.12.8932CrossRefPubMedGoogle Scholar
  90. Yamashita Y, Mizutani H, Torashima M, Takahashi M, Miyazaki K, Okamura H et al (1993a) Assessment of myometrial invasion by endometrial carcinoma: transvaginal sonography vs contrast-enhanced MR imaging. AJR Am J Roentgenol 161(3):595–599CrossRefGoogle Scholar
  91. Yamashita Y, Harada M, Sawada T, Takahashi M, Miyazaki K, Okamura H (1993b) Normal uterus and FIGO stage I endometrial carcinoma: dynamic gadolinium-enhanced MR imaging. Radiology 186(2):495–501CrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Serviço de Radiologia, Instituto Português de Oncologia de Lisboa Francisco GentilLisboaPortugal

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