Re-irradiation for Locally Recurrent Breast Cancer

Part of the Medical Radiology book series (MEDRAD)


Locally recurrent breast cancer occurs in 5–15 % of patients after breast conservation therapy and after mastectomy with adjuvant radiotherapy. Ipsilateral breast tumor recurrences may be salvaged with mastectomy; however, outcomes from repeat breast-conserving surgery and breast re-irradiation are promising. Chest wall recurrence generally portends a worse prognosis than in-breast local recurrences. A subset of patients may be long-term survivors in the absence of metastasis. Persistent chest wall disease can be symptomatic, and in previously irradiated patients, treatment options are limited. Experiences with chest wall re-irradiation have shown excellent response rates with acceptable late toxicity, but follow-up is limited.


Planning Target Volume Complete Response Rate Accelerate Partial Breast Irradiation Ipsilateral Breast Tumor Recurrence Partial Breast Irradiation 
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Copyright information

© Springer International Publishing Switerzland 2016

Authors and Affiliations

  1. 1.Department of Radiation OncologyUniversity of Nebraska Medical Center, Buffett Cancer Center, 987521 Nebraska MedicalOmahaUSA
  2. 2.Department of Radiation OncologyLoyola University, Cardinal Bernardin Cancer CenterMaywoodUSA

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